Synthesis, structural characterization and biological activity of Cu(II) compounds incorporating pyrazole-derived ligand: Effect on cell growth in human colorectal carcinoma

Chen Yi Li, Yu Ling Lien, Amitabha Datta, Wan Ting Chiu, Chin Lin Hsu, Jui Hsien Huang, Lance Horng, Chia Her Lind, Chi Jung Sue

研究成果: Article同行評審

1 引文 斯高帕斯(Scopus)

摘要

A series of Cu(II) compounds containing neutral multi-dentate ligand [2,6-diisopropylphenyl]-bis[(1-Hpyrazol-1-yl)methyl]amine (L 1) and pyrazole dimethoxethyl ligand [(1-H-pyrazol-1-yl)methyl]-bis(2-methoxyethyl) amine (L 2) were synthesized. Reactions of L 1 and L 2 with copper(II) chloride generate L 1CuCl 2 (1) and L 2CuCl 2 (2), respectively. Compounds 1 and 2 have been characterized by elemental analysis and X-ray single crystal diffractometry. The effects of compounds 1 and 2 on the cell viability of various human cancer cells (including A549, COLO 205, HT-29, Hep3B, HepG2, Huh7, and PCL5 cells) were investigated. The results indicate that compound 2 has a strong inhibitory effect on cell growth in human colorectal carcinoma cells (COLO 205 cells and HT-29 cells).

原文English
頁(從 - 到)696-703
頁數8
期刊Journal of the Chinese Chemical Society
59
發行號6
DOIs
出版狀態Published - 2012 六月 1

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

指紋 深入研究「Synthesis, structural characterization and biological activity of Cu(II) compounds incorporating pyrazole-derived ligand: Effect on cell growth in human colorectal carcinoma」主題。共同形成了獨特的指紋。

引用此