Quantification of dendrimer nanoparticle targeting on tumor cells by two-photon excitation fluorescence through a dual-clad optical fiber

Yu Chung Chang, Thommey P. Thomas, Jing Yong Ye, Alina Kotlyar, Zhengyi Cao, Istvan J. Majoros, James R. Baker, Theodore B. Norris

研究成果: Paper

摘要

We report the use of a dual-clad optical fiber to conduct quantitative two-photon excited fluorescence measurements in vitro and in vivo inside tumors. The ability to detect nanomolar concentrations of tumor cell targeting nanoparticles with this dual-clad fiber scheme is confirmed. The results indicate that this technique is an appropriate tool to quantify low concentrations of targeted fluorescence probes in vivo in deep tissue.

原文English
頁面BSuE4
DOIs
出版狀態Published - 2008
事件Biomedical Optics, BIOMED 2008 - St. Petersburg, FL, United States
持續時間: 2008 三月 162008 三月 19

Other

OtherBiomedical Optics, BIOMED 2008
國家United States
城市St. Petersburg, FL
期間08-03-1608-03-19

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

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