Quantification of dendrimer nanoparticle targeting on tumor cells by two-photon excitation fluorescence through a dual-clad optical fiber

Yu-Chung Chang, Thommey P. Thomas, Jing Yong Ye, Alina Kotlyar, Zhengyi Cao, Istvan J. Majoros, James R. Baker, Theodore B. Norris

研究成果: Paper

摘要

We report the use of a dual-clad optical fiber to conduct quantitative two-photon excited fluorescence measurements in vitro and in vivo inside tumors. The ability to detect nanomolar concentrations of tumor cell targeting nanoparticles with this dual-clad fiber scheme is confirmed. The results indicate that this technique is an appropriate tool to quantify low concentrations of targeted fluorescence probes in vivo in deep tissue.

原文English
出版狀態Published - 2008 十二月 1
事件Biomedical Optics, BIOMED 2008 - St. Petersburg, FL, United States
持續時間: 2008 三月 162008 三月 19

Other

OtherBiomedical Optics, BIOMED 2008
國家United States
城市St. Petersburg, FL
期間08-03-1608-03-19

    指紋

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

引用此

Chang, Y-C., Thomas, T. P., Ye, J. Y., Kotlyar, A., Cao, Z., Majoros, I. J., Baker, J. R., & Norris, T. B. (2008). Quantification of dendrimer nanoparticle targeting on tumor cells by two-photon excitation fluorescence through a dual-clad optical fiber. 論文發表於 Biomedical Optics, BIOMED 2008, St. Petersburg, FL, United States.