Photochemical activities of n-nitroso carboxamides and sulfoximides and their application to DNA cleavage

Jih Ru Hwu, Joseph Jen Tse Huang, Fu Yuan Tsai, Shwu Chen Tsay, Ming Hua Hsu, Kuo Chu Hwang, Jia Cherng Horng, Ja An Annie Ho, Chun Cheng Lin

研究成果: Article

8 引文 斯高帕斯(Scopus)

摘要

N-Nitroso compounds containing benzene, fluorene or fluorenone rings were synthesized. Photolysis of these compounds with 312-nm UV light provided the NO species, the presence of which was corroborated by use of an EPR method and of 2phenyl-4,4,5,5-tetramethylimidazolin-loxyl 3-oxide (PTIO) as a trapping agent. During irradiation of N-methylN-nitroso-9-fluorenone carboxamide (14c) in the absence of PTIO, it underwent decomposition followed by re-combination to give the heterocyclic nitric oxide radical 15. Incorporation of intercalating moieties endowed the Nnitroso compounds with DNA-cleaving ability through single-strand scission upon UV irradiation in a phosphate buffer (pH 5.0-8.0) under aerobic conditions.

原文English
頁(從 - 到)8742-8750
頁數9
期刊Chemistry - A European Journal
15
發行號35
DOIs
出版狀態Published - 2009 九月 7

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Organic Chemistry

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    Hwu, J. R., Huang, J. J. T., Tsai, F. Y., Tsay, S. C., Hsu, M. H., Hwang, K. C., Horng, J. C., Ho, J. A. A., & Lin, C. C. (2009). Photochemical activities of n-nitroso carboxamides and sulfoximides and their application to DNA cleavage. Chemistry - A European Journal, 15(35), 8742-8750. https://doi.org/10.1002/chem.200802571