Photo-induced DNA cleavage by (heterocyclo)carbonyl oxime esters of anthraquinone

Jih Ru Hwu, Jhih Ren Yang, Shwu Chen Tsay, Ming Hua Hsu, Yi Chieh Chen, Shang Shing P. Chou

研究成果: Article

18 引文 斯高帕斯(Scopus)

摘要

Various (heterocyclo)carbonyl mono-oxime esters of anthraquinone were synthesized, which exhibited an ability for DNA cleavage upon UV irradiation. Their structure-activity relationship was established, in which the most potent compound was anthraquinone O-9-(1,3-benzothiazole-2-carbonyl)oxime (4j). It can produce radical species and nick DNA at the concentration as low as 1.0 μM.

原文English
頁(從 - 到)3312-3315
頁數4
期刊Tetrahedron Letters
49
發行號20
DOIs
出版狀態Published - 2008 五月 12

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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