Phenyl-Carbonyl Coupling Reactions Promoted by Samarium Diiodide and Hexamethylphosphoramide

Jiann Shyng Shiue, Mei Huey Lin, Jim Min Fang

研究成果: Article

53 引文 斯高帕斯(Scopus)

摘要

By mediation of samarium diiodide and hexamethylphosphoramide, benzaldehydes and acetophenones underwent self- and cross-couplings to give the products having linkages at the para-carbons of phenyl rings and the carbonyl groups. The phenyl-carbonyl coupling of 2,5-dimethoxybenzaldehyde generated a Sm(III)-enolate intermediate, which was trapped by alkyl halides in a stereospecific manner to give uncommon 1,4-dialkyl-2,5-cyclohexadiene-1-carboxaldehydes. The benzaldehydes bearing tethered carbonyl chains proceeded with intramolecular phenyl-carbonyl couplings to afford fused benzocycles.

原文English
頁(從 - 到)4643-4649
頁數7
期刊Journal of Organic Chemistry
62
發行號14
DOIs
出版狀態Published - 1997 一月 1

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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