Palladium-Catalyzed Oxidative Cyclization for the Synthesis of 2-Alkylimidazo[5,1,2-cd]indolizines

Sanjay Kumar Ghosh, Debalina Ghosh, Ratnava Maitra, Ya Ting Kuo, Hon Man Lee

研究成果: Article同行評審

6 引文 斯高帕斯(Scopus)


An effective palladium-catalyzed direct arylation of 2-alkyl-imidazo[1,2-a]pyridine with alkynes towards imidazo[5,1,2-cd]indolizines through double C–H functionalization was developed. The catalyst system is an ionic palladium(II) complex bearing amido-functionalized N-heterocyclic carbene and triphenylphosphine ligands. A mere 2.5 mol-% loading of palladium was sufficient for catalyzing the reactions. Copper acetate and n-tetrabutylammonium bromide were employed as oxidant and phase-transfer catalyst, respectively. Beside imidazo[1,2-a]pyridine, desirably, less electron-rich derivatives could be employed as coupling partners. Also a wide range of diarylalkynes was used. The structure of one 2-alkyl-imidazo[5,1,2-cd]indolizine was established by single-crystal X-ray diffraction analysis. UV and PL spectra of the compounds confirmed that some are highly fluorescent. The method provides an easy synthetic route for the preparation of these new fluorescent materials.

頁(從 - 到)5722-5731
期刊European Journal of Organic Chemistry
出版狀態Published - 2016 一月 1

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Organic Chemistry

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