No evidence of correlation between mutation at codon 531 of src and the risk of colon cancer in Chinese

Nancy M. Wang, Kun Tu Yeh, Chan Hai Tsai, Shu Jung Chen, Jan Gowth Chang

研究成果: Article同行評審

38 引文 斯高帕斯(Scopus)

摘要

The protein tyrosine kinase activity of c-src proto-oncogene product, pp60(c-src), is elevated in a number of human cancers, including colon cancer. Phosphorylation of human pp60(c-src) carboxy-terminal tyrosine 530 suppresses its kinase activity. A recent report suggested that the risk of colon cancer is higher for those who carry a C → T transition mutation on codon 531 (Gln-531 → Amber-531) of src gene. This mutation caused a prematured translation termination and up-regulated the kinase activity. To examine whether this mutation could be a risk factor for colon carcinoma in the Chinese population, we used the same PCR-based assay to analyze src genotypes of 131 colon cancers and other various types of carcinoma. No mutation was detected in all specimens that were screened in this study. Thus, mutation at Gln-531 of src gene does not seem to be involved in the development of colon cancer in Chinese ethnicity. (C) 2000 Elsevier Science Ireland Ltd.

原文English
頁(從 - 到)201-204
頁數4
期刊Cancer Letters
150
發行號2
DOIs
出版狀態Published - 2000 三月 31

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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