Mutation analysis of the Bcl 10 gene in hepatocellular carcinoma.

K. T. Yeh, N. M. Wang, H. H. Lee, J. G. Chang

研究成果: Article

3 引文 (Scopus)

摘要

The Bcl 10 gene was recently discovered to be involved in the pathogenesis of lymphoma of mucosa-associated lymphoid tissue and several types of tumorous cell lines. We examined the mutation of Bcl 10 gene in 31 hepatocellular carcinomas along with their corresponding non-tumorous tissues by single strand conformation polymorphism (SSCP) and direct sequencing. The results showed that 11.3% chromosomes had codon 5 GCA to TCA mutation, 4.8% chromosomes had codon 8 CTC to CTG mutation, and 12.9% chromosomes had codon 213 GGA to GAA mutation. These mutations were found not only in the hepatoma tissues but also in paired non-cancerous tissues and the normal population. We suggest that these three changes are polymorphisms, and there is no relationship with the development of hepatocellular carcinoma.

原文English
頁(從 - 到)332-338
頁數7
期刊The Kaohsiung journal of medical sciences
16
發行號7
出版狀態Published - 2000 七月

指紋

Hepatocellular Carcinoma
Mutation
Codon
Chromosomes
Genes
Marginal Zone B-Cell Lymphoma
Cell Line
Population

All Science Journal Classification (ASJC) codes

  • Medicine(all)

引用此文

Yeh, K. T. ; Wang, N. M. ; Lee, H. H. ; Chang, J. G. / Mutation analysis of the Bcl 10 gene in hepatocellular carcinoma. 於: The Kaohsiung journal of medical sciences. 2000 ; 卷 16, 編號 7. 頁 332-338.
@article{716e7a684cd842f4ae3b1bf1e2e1b522,
title = "Mutation analysis of the Bcl 10 gene in hepatocellular carcinoma.",
abstract = "The Bcl 10 gene was recently discovered to be involved in the pathogenesis of lymphoma of mucosa-associated lymphoid tissue and several types of tumorous cell lines. We examined the mutation of Bcl 10 gene in 31 hepatocellular carcinomas along with their corresponding non-tumorous tissues by single strand conformation polymorphism (SSCP) and direct sequencing. The results showed that 11.3{\%} chromosomes had codon 5 GCA to TCA mutation, 4.8{\%} chromosomes had codon 8 CTC to CTG mutation, and 12.9{\%} chromosomes had codon 213 GGA to GAA mutation. These mutations were found not only in the hepatoma tissues but also in paired non-cancerous tissues and the normal population. We suggest that these three changes are polymorphisms, and there is no relationship with the development of hepatocellular carcinoma.",
author = "Yeh, {K. T.} and Wang, {N. M.} and Lee, {H. H.} and Chang, {J. G.}",
year = "2000",
month = "7",
language = "English",
volume = "16",
pages = "332--338",
journal = "Kaohsiung Journal of Medical Sciences",
issn = "1607-551X",
publisher = "Elsevier (Singapore) Pte Ltd",
number = "7",

}

Mutation analysis of the Bcl 10 gene in hepatocellular carcinoma. / Yeh, K. T.; Wang, N. M.; Lee, H. H.; Chang, J. G.

於: The Kaohsiung journal of medical sciences, 卷 16, 編號 7, 07.2000, p. 332-338.

研究成果: Article

TY - JOUR

T1 - Mutation analysis of the Bcl 10 gene in hepatocellular carcinoma.

AU - Yeh, K. T.

AU - Wang, N. M.

AU - Lee, H. H.

AU - Chang, J. G.

PY - 2000/7

Y1 - 2000/7

N2 - The Bcl 10 gene was recently discovered to be involved in the pathogenesis of lymphoma of mucosa-associated lymphoid tissue and several types of tumorous cell lines. We examined the mutation of Bcl 10 gene in 31 hepatocellular carcinomas along with their corresponding non-tumorous tissues by single strand conformation polymorphism (SSCP) and direct sequencing. The results showed that 11.3% chromosomes had codon 5 GCA to TCA mutation, 4.8% chromosomes had codon 8 CTC to CTG mutation, and 12.9% chromosomes had codon 213 GGA to GAA mutation. These mutations were found not only in the hepatoma tissues but also in paired non-cancerous tissues and the normal population. We suggest that these three changes are polymorphisms, and there is no relationship with the development of hepatocellular carcinoma.

AB - The Bcl 10 gene was recently discovered to be involved in the pathogenesis of lymphoma of mucosa-associated lymphoid tissue and several types of tumorous cell lines. We examined the mutation of Bcl 10 gene in 31 hepatocellular carcinomas along with their corresponding non-tumorous tissues by single strand conformation polymorphism (SSCP) and direct sequencing. The results showed that 11.3% chromosomes had codon 5 GCA to TCA mutation, 4.8% chromosomes had codon 8 CTC to CTG mutation, and 12.9% chromosomes had codon 213 GGA to GAA mutation. These mutations were found not only in the hepatoma tissues but also in paired non-cancerous tissues and the normal population. We suggest that these three changes are polymorphisms, and there is no relationship with the development of hepatocellular carcinoma.

UR - http://www.scopus.com/inward/record.url?scp=0034218248&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034218248&partnerID=8YFLogxK

M3 - Article

C2 - 11079291

AN - SCOPUS:0034218248

VL - 16

SP - 332

EP - 338

JO - Kaohsiung Journal of Medical Sciences

JF - Kaohsiung Journal of Medical Sciences

SN - 1607-551X

IS - 7

ER -