Ligand-Assisted Rate Acceleration in Transacylation by a Yttrium - Salen Complex. Demonstration of a Conceptually New Strategy for Metal-Catalyzed Kinetic Resolution of Alcohols

Mei Huey Lin, T. V. RajanBabu

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65 引文 斯高帕斯(Scopus)

摘要

(matrix presented) Yttrium-salen complexes effect transacylation between enolesters and chiral secondary alcohols, resulting in varying degrees of kinetic resolution. Even though the enantioselectivity remains modest (kfast/kslow up to 4.81), these results represent the first demonstration of a conceptually new metal-catalyzed acyl transfer process that results in kinetic resolution. On the basis of the solid-state structure of the catalyst, a novel associative mechanistic pathway is proposed for the reaction.

原文English
頁(從 - 到)1607-1610
頁數4
期刊Organic Letters
4
發行號9
DOIs
出版狀態Published - 2002 五月 2

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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