Effects of KRAS mutation and polymorphism on the risk and prognosis of oral squamous cell carcinoma

Wen Yi Wang, Yi Chih Chien, Yong Kie Wong, Yan Liang Lin, Jin Ching Lin

研究成果: Article同行評審

25 引文 斯高帕斯(Scopus)

摘要

Background Mutations or single nucleotide polymorphism (SNP) of relevant genes may affect the risk and prognosis of malignancies. The purpose of this study was to analyze whether the KRAS polymorphisms and mutations can be useful prognostic or risk markers in oral squamous cell carcinoma (OSCC). Methods DNA was extracted from tumor tissues of 47 patients with OSCC and blood cells of 84 normal controls and subjected to sequencing for the KRAS. Results No mutation in the KRAS was found in 47 OSCC samples. However, 2 polymorphisms (rs1137282 and rs712) were detected. Individuals with KRAS SNP rs712 genotypes of G/T or T/T have a reduced risk for OSCC than those with genotype G/G (hazard ratio [HR], 0.26; 95% confidence interval [CI], 0.10-0.60; p =.004). The overall survival between different SNPs were not statistically significant (p =.147 for rs1137282 and p =.202 for rs712). Conclusion These data demonstrate a role for rs712 polymorphism of the KRAS in susceptibility of OSCC.

原文English
頁(從 - 到)663-666
頁數4
期刊Head and Neck
34
發行號5
DOIs
出版狀態Published - 2012 五月 1

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

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