Drug delivery system design and development for boron neutron capture therapy on cancer treatment

Lin Chiang Sherlock Huang, Wen Yuan Hsieh, Jiun Yu Chen, Su Chin Huang, Jen Kun Chen, Ming Hua Hsu

研究成果: Article

7 引文 斯高帕斯(Scopus)

摘要

We have already synthesized a boron-containing polymeric micellar drug delivery system for boron neutron capture therapy (BNCT). The synthesized diblock copolymer, boron-terminated copolymers (Bpin-PLA-PEOz), consisted of biodegradable poly(D,. l-lactide) (PLA) block and water-soluble polyelectrolyte poly(2-ethyl-2-oxazoline) (PEOz) block, and a cap of pinacol boronate ester (Bpin). In this study, we have demonstrated that synthesized Bpin-PLA-PEOz micelle has great potential to be boron drug delivery system with preliminary evaluation of biocompatibility and boron content.

原文English
頁(從 - 到)89-93
頁數5
期刊Applied Radiation and Isotopes
88
DOIs
出版狀態Published - 2014 六月

    指紋

All Science Journal Classification (ASJC) codes

  • Radiation

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