Differentiation of remitting neuromyelitis optica spectrum disorders from multiple sclerosis by integrating parameters from serum proteins and lymphocyte subsets

Peng Peng Ip, Chen Yen Chung, Chien Ching Chang, Yu Fang Lee, Hui Min Wang, Ie Bin Lian, Cathy Shen Jang Fann, Chih Chao Yang, Fang Liao

研究成果: Article

2 引文 斯高帕斯(Scopus)

摘要

Differential diagnosis for neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) is always doubtful. To differentiate these diseases, we studied the immune status in the blood of patients with MS (n = 45) or NMOSD (n = 23) at remission phase. Remitting NMOSD patients had increased levels of CXCL13 and memory B cells, while remitting MS patients had elevated levels of galectin-9 and Th1 cells. A diagnostic model with these four variables is built to distinguish remitting NMOSD from MS with a sensitivity of 91.30%. Our diagnostic model may help to improve the differentiation of remitting NMOSD from MS.

原文English
頁(從 - 到)45-52
頁數8
期刊Journal of Neuroimmunology
318
DOIs
出版狀態Published - 2018 五月 15

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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