The status of EGFR CA SSR1 is a potential prognostic factor for patients with oral squamous cell carcinoma

Yan Liang Lin, Wen Yi Wang, Jin Ching Lin, Yong Kie Wong, Yi-Chih Chien

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The EGFR is an oncogene known to be involved in the development and progression of many cancers. It has been reported that the expression of EGFR and EGFR CA simple sequence repeat 1 (CA SSR1) repeat numbers in tumors can be useful prognostic factors in several cancer types. The objective of the present study was to analyze whether the EGFR polymorphism can be a useful prognostic factor in OSCC in the Taiwanese population. OSCC tissues were collected from 47 patients by surgical excision. The genotyping of EGFR were performed with the ABI Prism 3100 Genetic Analyzer. OSCC patients had a tendency toward an allelic imbalance of CA SSR1. The results also suggested that OSCC patients who were homozygous for CA SSR1 had a poorer prognosis than those who were heterozygous (P < 0.001). Besides, patients with an allelic imbalance of CA SSR1 had significantly lower overall and disease free survival rates than those without, using the Kaplan-Meier method (P < 0.001). This suggests that the status of CA SSR1 has the potential to be a useful prognosis factor in OSCC.

Original languageEnglish
Pages (from-to)482-486
Number of pages5
JournalOral Oncology
Volume47
Issue number6
DOIs
Publication statusPublished - 2011 Jun 1

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Microsatellite Repeats
Squamous Cell Carcinoma
Allelic Imbalance
Neoplasms
Oncogenes
Disease-Free Survival
Survival Rate
Population

All Science Journal Classification (ASJC) codes

  • Oral Surgery
  • Oncology
  • Cancer Research

Cite this

Lin, Yan Liang ; Wang, Wen Yi ; Lin, Jin Ching ; Wong, Yong Kie ; Chien, Yi-Chih. / The status of EGFR CA SSR1 is a potential prognostic factor for patients with oral squamous cell carcinoma. In: Oral Oncology. 2011 ; Vol. 47, No. 6. pp. 482-486.
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abstract = "The EGFR is an oncogene known to be involved in the development and progression of many cancers. It has been reported that the expression of EGFR and EGFR CA simple sequence repeat 1 (CA SSR1) repeat numbers in tumors can be useful prognostic factors in several cancer types. The objective of the present study was to analyze whether the EGFR polymorphism can be a useful prognostic factor in OSCC in the Taiwanese population. OSCC tissues were collected from 47 patients by surgical excision. The genotyping of EGFR were performed with the ABI Prism 3100 Genetic Analyzer. OSCC patients had a tendency toward an allelic imbalance of CA SSR1. The results also suggested that OSCC patients who were homozygous for CA SSR1 had a poorer prognosis than those who were heterozygous (P < 0.001). Besides, patients with an allelic imbalance of CA SSR1 had significantly lower overall and disease free survival rates than those without, using the Kaplan-Meier method (P < 0.001). This suggests that the status of CA SSR1 has the potential to be a useful prognosis factor in OSCC.",
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The status of EGFR CA SSR1 is a potential prognostic factor for patients with oral squamous cell carcinoma. / Lin, Yan Liang; Wang, Wen Yi; Lin, Jin Ching; Wong, Yong Kie; Chien, Yi-Chih.

In: Oral Oncology, Vol. 47, No. 6, 01.06.2011, p. 482-486.

Research output: Contribution to journalArticle

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