The effect of temperature and standings can cause deviations in prostate specific antigen (PSA) assays

Chiu-Lan Hsieh; Ching Yuan Chang; Wang Sheng Ko; Bor Shah Chen; Kuan Chou Chen; Robert Y. Peng

doi:10.1080/00032710701585677

The effect of temperature and standings can cause deviations in prostate specific antigen (PSA) assays

Chiu-Lan Hsieh, Ching Yuan Chang, Wang Sheng Ko, Bor Shah Chen, Kuan Chou Chen, Robert Y. Peng

Department of Biology

Research output: Contribution to journal › Article

Abstract

Blood samples were assayed for PSA values immediately after sampled or by standing for an assigned period. Variation of the free- (f), total- (t) values, and the free to total (f/t) ratios were determined. Mathematical models were used to interpret the phenomena of deviation. Smaller values of PSA values changed randomly with time and temperature of standings, resulting in varying f/t ratios, while larger initial PSA values were relatively unaffected to any significant extent. Model interpreted that the changes of PSA values might be caused by higher temperature and time of standings, and conformational participation was also possible.

Original language	English
Pages (from-to)	2485-2496
Number of pages	12
Journal	Analytical Letters
Volume	40
Issue number	13
DOIs	https://doi.org/10.1080/00032710701585677
Publication status	Published - 2007 Jan 1

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All Science Journal Classification (ASJC) codes

Analytical Chemistry
Biochemistry
Spectroscopy
Clinical Biochemistry
Biochemistry, medical
Electrochemistry

Cite this

Hsieh, C-L., Chang, C. Y., Ko, W. S., Chen, B. S., Chen, K. C., & Peng, R. Y. (2007). The effect of temperature and standings can cause deviations in prostate specific antigen (PSA) assays. Analytical Letters, 40(13), 2485-2496. https://doi.org/10.1080/00032710701585677

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10.1080/00032710701585677