Abstract
The Fe3O4 nanoparticles, tailored with maleimidyl 3-succinimidopropionate ligands, were conjugated with paclitaxel molecules that were attached with a poly(ethylene glycol) (PEG) spacer through a phosphodiester moiety at the (C-2')-OH position. The average number of paclitaxel molecules/nanoparticles was determined as 83. These nanoparticles liberated paclitaxel molecules upon exposure to phosphodiesterase.
Original language | English |
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Pages (from-to) | 66-68 |
Number of pages | 3 |
Journal | Journal of the American Chemical Society |
Volume | 131 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2009 Jan 14 |
All Science Journal Classification (ASJC) codes
- Catalysis
- Chemistry(all)
- Biochemistry
- Colloid and Surface Chemistry