Targeted paclitaxel by conjugation to iron oxide and gold nanoparticles

Jih Ru Hwu, Yu Sern Lin, Thainashmuthu Josephrajan, Ming Hua Hsu, Fong Yu Cheng, Chen Sheng Yeh, Wu Chou Su, Dar Bin Shieh

Research output: Contribution to journalArticle

141 Citations (Scopus)

Abstract

The Fe3O4 nanoparticles, tailored with maleimidyl 3-succinimidopropionate ligands, were conjugated with paclitaxel molecules that were attached with a poly(ethylene glycol) (PEG) spacer through a phosphodiester moiety at the (C-2')-OH position. The average number of paclitaxel molecules/nanoparticles was determined as 83. These nanoparticles liberated paclitaxel molecules upon exposure to phosphodiesterase.

Original languageEnglish
Pages (from-to)66-68
Number of pages3
JournalJournal of the American Chemical Society
Volume131
Issue number1
DOIs
Publication statusPublished - 2009 Jan 14

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Fingerprint Dive into the research topics of 'Targeted paclitaxel by conjugation to iron oxide and gold nanoparticles'. Together they form a unique fingerprint.

  • Cite this

    Hwu, J. R., Lin, Y. S., Josephrajan, T., Hsu, M. H., Cheng, F. Y., Yeh, C. S., Su, W. C., & Shieh, D. B. (2009). Targeted paclitaxel by conjugation to iron oxide and gold nanoparticles. Journal of the American Chemical Society, 131(1), 66-68. https://doi.org/10.1021/ja804947u