Targeted paclitaxel by conjugation to iron oxide and gold nanoparticles

Jih Ru Hwu; Yu Sern Lin; Thainashmuthu Josephrajan; Ming Hua Hsu; Fong Yu Cheng; Chen Sheng Yeh; Wu Chou Su; Dar Bin Shieh

doi:10.1021/ja804947u

Targeted paclitaxel by conjugation to iron oxide and gold nanoparticles

Jih Ru Hwu, Yu Sern Lin, Thainashmuthu Josephrajan, Ming Hua Hsu, Fong Yu Cheng, Chen Sheng Yeh, Wu Chou Su, Dar Bin Shieh

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

144 Citations (Scopus)

Abstract

The Fe₃O₄ nanoparticles, tailored with maleimidyl 3-succinimidopropionate ligands, were conjugated with paclitaxel molecules that were attached with a poly(ethylene glycol) (PEG) spacer through a phosphodiester moiety at the (C-2')-OH position. The average number of paclitaxel molecules/nanoparticles was determined as 83. These nanoparticles liberated paclitaxel molecules upon exposure to phosphodiesterase.

Original language	English
Pages (from-to)	66-68
Number of pages	3
Journal	Journal of the American Chemical Society
Volume	131
Issue number	1
DOIs	https://doi.org/10.1021/ja804947u
Publication status	Published - 2009 Jan 14

All Science Journal Classification (ASJC) codes

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja804947u

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AU - Lin, Yu Sern

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AU - Cheng, Fong Yu

AU - Yeh, Chen Sheng

AU - Su, Wu Chou

AU - Shieh, Dar Bin

PY - 2009/1/14

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N2 - The Fe3O4 nanoparticles, tailored with maleimidyl 3-succinimidopropionate ligands, were conjugated with paclitaxel molecules that were attached with a poly(ethylene glycol) (PEG) spacer through a phosphodiester moiety at the (C-2')-OH position. The average number of paclitaxel molecules/nanoparticles was determined as 83. These nanoparticles liberated paclitaxel molecules upon exposure to phosphodiesterase.

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