Synthesis, structure and reactivity of azosalophen complexes of vanadium(IV): Studies on cytotoxic properties

Poulami Pattanayak, Jahar Lal Pratihar, Debprasad Patra, Soham Mitra, Arindam Bhattacharyya, Hon Man Lee, Surajit Chattopadhyay

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Abstract

The free ligands, 2-{(o-hydroxyaryl)azo}-1-N-salicylidene phenylamine, H2L [where H2L = RC6H4NNC 6H4NCH-C6H4OHR = p-H for H 2L1, p-Me for H2L2 and p-Cl for H2L3], were prepared by the condensation of salicylaldehyde with 2-{(o-hydroxy aryl)azo} aniline. Reaction of H2L with VOSO4 afforded the oxovanadium complex, (L)V(O)(H 2O). The (L1)V(O)(H2O) complex displays two reversible responses at 0.7 V and -0.65 V vs. SCE in cyclic voltammetry. Catalytic activity of (L1)V(O)(H2O) toward H 2O2 induced oxidation of organic thioethers to sulfoxide and sulfones have been examined. The cytotoxicity of (L1)V(O)(H 2O) has also been examined on human lung cancer cells.

Original languageEnglish
Pages (from-to)6220-6230
Number of pages11
JournalDalton Transactions
Issue number31
DOIs
Publication statusPublished - 2009 Aug 10

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All Science Journal Classification (ASJC) codes

  • Inorganic Chemistry

Cite this

Pattanayak, P., Pratihar, J. L., Patra, D., Mitra, S., Bhattacharyya, A., Man Lee, H., & Chattopadhyay, S. (2009). Synthesis, structure and reactivity of azosalophen complexes of vanadium(IV): Studies on cytotoxic properties. Dalton Transactions, (31), 6220-6230. https://doi.org/10.1039/b903352a