Synthesis, structural characterization and biological activity of Cu(II) compounds incorporating pyrazole-derived ligand: Effect on cell growth in human colorectal carcinoma

Chen Yi Li, Yu Ling Lien, Amitabha Datta, Wan Ting Chiu, Chin Lin Hsu, Jui Hsien Huang, Lance Horng, Chia Her Lind, Chi Jung Sue

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Abstract

A series of Cu(II) compounds containing neutral multi-dentate ligand [2,6-diisopropylphenyl]-bis[(1-Hpyrazol-1-yl)methyl]amine (L 1) and pyrazole dimethoxethyl ligand [(1-H-pyrazol-1-yl)methyl]-bis(2-methoxyethyl) amine (L 2) were synthesized. Reactions of L 1 and L 2 with copper(II) chloride generate L 1CuCl 2 (1) and L 2CuCl 2 (2), respectively. Compounds 1 and 2 have been characterized by elemental analysis and X-ray single crystal diffractometry. The effects of compounds 1 and 2 on the cell viability of various human cancer cells (including A549, COLO 205, HT-29, Hep3B, HepG2, Huh7, and PCL5 cells) were investigated. The results indicate that compound 2 has a strong inhibitory effect on cell growth in human colorectal carcinoma cells (COLO 205 cells and HT-29 cells).

Original languageEnglish
Pages (from-to)696-703
Number of pages8
JournalJournal of the Chinese Chemical Society
Volume59
Issue number6
DOIs
Publication statusPublished - 2012 Jun 1

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All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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