Synthesis, structural characterization and biological activity of Cu(II) compounds incorporating pyrazole-derived ligand: Effect on cell growth in human colorectal carcinoma

Chen Yi Li, Yu Ling Lien, Amitabha Datta, Wan Ting Chiu, Chin Lin Hsu, Jui Hsien Huang, Lance Horng, Chia Her Lind, Chi Jung Sue

Research output: Contribution to journalArticle

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Abstract

A series of Cu(II) compounds containing neutral multi-dentate ligand [2,6-diisopropylphenyl]-bis[(1-Hpyrazol-1-yl)methyl]amine (L 1) and pyrazole dimethoxethyl ligand [(1-H-pyrazol-1-yl)methyl]-bis(2-methoxyethyl) amine (L 2) were synthesized. Reactions of L 1 and L 2 with copper(II) chloride generate L 1CuCl 2 (1) and L 2CuCl 2 (2), respectively. Compounds 1 and 2 have been characterized by elemental analysis and X-ray single crystal diffractometry. The effects of compounds 1 and 2 on the cell viability of various human cancer cells (including A549, COLO 205, HT-29, Hep3B, HepG2, Huh7, and PCL5 cells) were investigated. The results indicate that compound 2 has a strong inhibitory effect on cell growth in human colorectal carcinoma cells (COLO 205 cells and HT-29 cells).

Original languageEnglish
Pages (from-to)696-703
Number of pages8
JournalJournal of the Chinese Chemical Society
Volume59
Issue number6
DOIs
Publication statusPublished - 2012 Jun 1

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Cell growth
Bioactivity
Cells
Ligands
Amines
Single crystals
X rays
Chemical analysis
pyrazole

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

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title = "Synthesis, structural characterization and biological activity of Cu(II) compounds incorporating pyrazole-derived ligand: Effect on cell growth in human colorectal carcinoma",
abstract = "A series of Cu(II) compounds containing neutral multi-dentate ligand [2,6-diisopropylphenyl]-bis[(1-Hpyrazol-1-yl)methyl]amine (L 1) and pyrazole dimethoxethyl ligand [(1-H-pyrazol-1-yl)methyl]-bis(2-methoxyethyl) amine (L 2) were synthesized. Reactions of L 1 and L 2 with copper(II) chloride generate L 1CuCl 2 (1) and L 2CuCl 2 (2), respectively. Compounds 1 and 2 have been characterized by elemental analysis and X-ray single crystal diffractometry. The effects of compounds 1 and 2 on the cell viability of various human cancer cells (including A549, COLO 205, HT-29, Hep3B, HepG2, Huh7, and PCL5 cells) were investigated. The results indicate that compound 2 has a strong inhibitory effect on cell growth in human colorectal carcinoma cells (COLO 205 cells and HT-29 cells).",
author = "Li, {Chen Yi} and Lien, {Yu Ling} and Amitabha Datta and Chiu, {Wan Ting} and Hsu, {Chin Lin} and Huang, {Jui Hsien} and Lance Horng and Lind, {Chia Her} and Sue, {Chi Jung}",
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Synthesis, structural characterization and biological activity of Cu(II) compounds incorporating pyrazole-derived ligand : Effect on cell growth in human colorectal carcinoma. / Li, Chen Yi; Lien, Yu Ling; Datta, Amitabha; Chiu, Wan Ting; Hsu, Chin Lin; Huang, Jui Hsien; Horng, Lance; Lind, Chia Her; Sue, Chi Jung.

In: Journal of the Chinese Chemical Society, Vol. 59, No. 6, 01.06.2012, p. 696-703.

Research output: Contribution to journalArticle

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AU - Li, Chen Yi

AU - Lien, Yu Ling

AU - Datta, Amitabha

AU - Chiu, Wan Ting

AU - Hsu, Chin Lin

AU - Huang, Jui Hsien

AU - Horng, Lance

AU - Lind, Chia Her

AU - Sue, Chi Jung

PY - 2012/6/1

Y1 - 2012/6/1

N2 - A series of Cu(II) compounds containing neutral multi-dentate ligand [2,6-diisopropylphenyl]-bis[(1-Hpyrazol-1-yl)methyl]amine (L 1) and pyrazole dimethoxethyl ligand [(1-H-pyrazol-1-yl)methyl]-bis(2-methoxyethyl) amine (L 2) were synthesized. Reactions of L 1 and L 2 with copper(II) chloride generate L 1CuCl 2 (1) and L 2CuCl 2 (2), respectively. Compounds 1 and 2 have been characterized by elemental analysis and X-ray single crystal diffractometry. The effects of compounds 1 and 2 on the cell viability of various human cancer cells (including A549, COLO 205, HT-29, Hep3B, HepG2, Huh7, and PCL5 cells) were investigated. The results indicate that compound 2 has a strong inhibitory effect on cell growth in human colorectal carcinoma cells (COLO 205 cells and HT-29 cells).

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