Abstract
A series of Cu(II) compounds containing neutral multi-dentate ligand [2,6-diisopropylphenyl]-bis[(1-Hpyrazol-1-yl)methyl]amine (L 1) and pyrazole dimethoxethyl ligand [(1-H-pyrazol-1-yl)methyl]-bis(2-methoxyethyl) amine (L 2) were synthesized. Reactions of L 1 and L 2 with copper(II) chloride generate L 1CuCl 2 (1) and L 2CuCl 2 (2), respectively. Compounds 1 and 2 have been characterized by elemental analysis and X-ray single crystal diffractometry. The effects of compounds 1 and 2 on the cell viability of various human cancer cells (including A549, COLO 205, HT-29, Hep3B, HepG2, Huh7, and PCL5 cells) were investigated. The results indicate that compound 2 has a strong inhibitory effect on cell growth in human colorectal carcinoma cells (COLO 205 cells and HT-29 cells).
| Original language | English |
|---|---|
| Pages (from-to) | 696-703 |
| Number of pages | 8 |
| Journal | Journal of the Chinese Chemical Society |
| Volume | 59 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2012 Jun 1 |
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All Science Journal Classification (ASJC) codes
- Chemistry(all)
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Synthesis, structural characterization and biological activity of Cu(II) compounds incorporating pyrazole-derived ligand : Effect on cell growth in human colorectal carcinoma. / Li, Chen Yi; Lien, Yu Ling; Datta, Amitabha; Chiu, Wan Ting; Hsu, Chin Lin; Huang, Jui Hsien; Horng, Lance; Lind, Chia Her; Sue, Chi Jung.
In: Journal of the Chinese Chemical Society, Vol. 59, No. 6, 01.06.2012, p. 696-703.Research output: Contribution to journal › Article
TY - JOUR
T1 - Synthesis, structural characterization and biological activity of Cu(II) compounds incorporating pyrazole-derived ligand
T2 - Effect on cell growth in human colorectal carcinoma
AU - Li, Chen Yi
AU - Lien, Yu Ling
AU - Datta, Amitabha
AU - Chiu, Wan Ting
AU - Hsu, Chin Lin
AU - Huang, Jui Hsien
AU - Horng, Lance
AU - Lind, Chia Her
AU - Sue, Chi Jung
PY - 2012/6/1
Y1 - 2012/6/1
N2 - A series of Cu(II) compounds containing neutral multi-dentate ligand [2,6-diisopropylphenyl]-bis[(1-Hpyrazol-1-yl)methyl]amine (L 1) and pyrazole dimethoxethyl ligand [(1-H-pyrazol-1-yl)methyl]-bis(2-methoxyethyl) amine (L 2) were synthesized. Reactions of L 1 and L 2 with copper(II) chloride generate L 1CuCl 2 (1) and L 2CuCl 2 (2), respectively. Compounds 1 and 2 have been characterized by elemental analysis and X-ray single crystal diffractometry. The effects of compounds 1 and 2 on the cell viability of various human cancer cells (including A549, COLO 205, HT-29, Hep3B, HepG2, Huh7, and PCL5 cells) were investigated. The results indicate that compound 2 has a strong inhibitory effect on cell growth in human colorectal carcinoma cells (COLO 205 cells and HT-29 cells).
AB - A series of Cu(II) compounds containing neutral multi-dentate ligand [2,6-diisopropylphenyl]-bis[(1-Hpyrazol-1-yl)methyl]amine (L 1) and pyrazole dimethoxethyl ligand [(1-H-pyrazol-1-yl)methyl]-bis(2-methoxyethyl) amine (L 2) were synthesized. Reactions of L 1 and L 2 with copper(II) chloride generate L 1CuCl 2 (1) and L 2CuCl 2 (2), respectively. Compounds 1 and 2 have been characterized by elemental analysis and X-ray single crystal diffractometry. The effects of compounds 1 and 2 on the cell viability of various human cancer cells (including A549, COLO 205, HT-29, Hep3B, HepG2, Huh7, and PCL5 cells) were investigated. The results indicate that compound 2 has a strong inhibitory effect on cell growth in human colorectal carcinoma cells (COLO 205 cells and HT-29 cells).
UR - http://www.scopus.com/inward/record.url?scp=84862557128&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862557128&partnerID=8YFLogxK
U2 - 10.1002/jccs.201100396
DO - 10.1002/jccs.201100396
M3 - Article
AN - SCOPUS:84862557128
VL - 59
SP - 696
EP - 703
JO - Journal of the Chinese Chemical Society
JF - Journal of the Chinese Chemical Society
SN - 0009-4536
IS - 6
ER -