Synthesis of 2-alkenyl-2H-indazoles from 2-(2-carbonylmethyl)-2H-indazoles

Mei Huey Lin, Kung Yu Liang, Chang Hsien Tsai, Yu Chun Chen, Hung Chang Hsiao, Yi Syuan Li, Chung Hao Chen, Hau Chun Wu

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Abstract

A procedure has been developed for synthesis of 2-alkenyl-2H-indazoles starting from 2-(2-carbonylmethyl)-2H-indazoles, which are prepared by gallium/aluminium- and aluminium-mediated, direct, regioselective alkylation of indazoles with α-bromocarbonyl compounds. The structure of 3-(2H-indazol-2-yl)-2H-chromen-2-one was proven by X-ray crystallography. The styrene- and coumarin-2H-indazoles produced by using the newmethod were found to have interesting fluorescence properties.

Original languageEnglish
Article number238
JournalMolecules
Volume21
Issue number2
DOIs
Publication statusPublished - 2016 Feb

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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    Lin, M. H., Liang, K. Y., Tsai, C. H., Chen, Y. C., Hsiao, H. C., Li, Y. S., Chen, C. H., & Wu, H. C. (2016). Synthesis of 2-alkenyl-2H-indazoles from 2-(2-carbonylmethyl)-2H-indazoles. Molecules, 21(2), [238]. https://doi.org/10.3390/molecules21020238