Synthesis, characterization and cancer cell growth inhibition activity of ruthenium(II) complexes bearing bidentate pyrrole-imine ligands

Guan Hao Chen, Wohn Jenn Leu, Jih Hwa Guh, Chia Her Lin, Jui Hsien Huang

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4 Citations (Scopus)

Abstract

A series of bidentate pyrrole-imine ligands, [C4H3NH-(2-CH=N-R)] (1, R = cyclohexenyl; 2, R = CH2CH2-1-cyclohexenyl; 3, R = tBu; 4, R = CH2-2-furyl; 5, R = 2-methoxylphenyl; 6, R = phenyl; 7, R = 3-nitrophenyl; 8, R = 2,6-di-isopropylphenyl; 9, R = 2,4,6-trimethylphenyl), were synthesized and their corresponding ruthenium metal compounds {Ru (ɳ6-p-cymene)[C4H3N-(2-CH=N-R)]Cl} (Ru-1∼Ru-9) were also synthesized. These ligands and ruthenium compounds were all characterized by 1H and 13C NMR spectroscopy and some of their structures are also determined by single crystal X-ray crystallography. The Ru-1∼Ru-9 showed excellent GI50 for PC-3 and DU-145 with the range of 3.83–12.13 and 4.25–11.22 μM, respectively. Among of these ruthenium compounds, Ru-6 has the best activity indicating phenyl ring is the key group on the imine substituents of these ruthenium compounds.

Original languageEnglish
Pages (from-to)122-130
Number of pages9
JournalJournal of Organometallic Chemistry
Volume868
DOIs
Publication statusPublished - 2018 Aug 1

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

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