Synthesis and biological evaluation of ether bridged bicyclic iminosugar derivatives

Jiun Ly Chir; Pey Jiuann Wu; Wei Zou; Milan Bhasin; Wei Fu Juang; Chao Qi Guo; An Tai Wu

doi:10.1016/j.carres.2009.05.029

Synthesis and biological evaluation of ether bridged bicyclic iminosugar derivatives

Jiun Ly Chir, Pey Jiuann Wu, Wei Zou, Milan Bhasin, Wei Fu Juang, Chao Qi Guo, An Tai Wu

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Bicyclic iminosugar derivatives with an ether bridge bearing different substituents on C-2 and the nitrogen atom have been synthesized from a C-glycoside bearing an isopropylidene acetal. The activities of these compounds were investigated against several glycosidase enzymes and showed moderate inhibition and activation.

Original language	English
Pages (from-to)	1639-1645
Number of pages	7
Journal	Carbohydrate Research
Volume	344
Issue number	13
DOIs	https://doi.org/10.1016/j.carres.2009.05.029
Publication status	Published - 2009 Sep 8

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Biochemistry
Organic Chemistry

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title = "Synthesis and biological evaluation of ether bridged bicyclic iminosugar derivatives",

abstract = "Bicyclic iminosugar derivatives with an ether bridge bearing different substituents on C-2 and the nitrogen atom have been synthesized from a C-glycoside bearing an isopropylidene acetal. The activities of these compounds were investigated against several glycosidase enzymes and showed moderate inhibition and activation.",

author = "Chir, {Jiun Ly} and Wu, {Pey Jiuann} and Wei Zou and Milan Bhasin and Juang, {Wei Fu} and Guo, {Chao Qi} and Wu, {An Tai}",

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AU - Chir, Jiun Ly

AU - Wu, Pey Jiuann

AU - Zou, Wei

AU - Bhasin, Milan

AU - Juang, Wei Fu

AU - Guo, Chao Qi

AU - Wu, An Tai

PY - 2009/9/8

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AB - Bicyclic iminosugar derivatives with an ether bridge bearing different substituents on C-2 and the nitrogen atom have been synthesized from a C-glycoside bearing an isopropylidene acetal. The activities of these compounds were investigated against several glycosidase enzymes and showed moderate inhibition and activation.

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