Synthesis and biological evaluation of ether bridged bicyclic iminosugar derivatives

Jiun Ly Chir, Pey Jiuann Wu, Wei Zou, Milan Bhasin, Wei Fu Juang, Chao Qi Guo, An-Tai Wu

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Bicyclic iminosugar derivatives with an ether bridge bearing different substituents on C-2 and the nitrogen atom have been synthesized from a C-glycoside bearing an isopropylidene acetal. The activities of these compounds were investigated against several glycosidase enzymes and showed moderate inhibition and activation.

Original languageEnglish
Pages (from-to)1639-1645
Number of pages7
JournalCarbohydrate Research
Volume344
Issue number13
DOIs
Publication statusPublished - 2009 Sep 8

Fingerprint

Bearings (structural)
Bridge bearings
Acetals
Glycoside Hydrolases
Ether
Nitrogen
Chemical activation
Derivatives
Atoms
Enzymes
propylene
C-glycoside

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

Cite this

Chir, Jiun Ly ; Wu, Pey Jiuann ; Zou, Wei ; Bhasin, Milan ; Juang, Wei Fu ; Guo, Chao Qi ; Wu, An-Tai. / Synthesis and biological evaluation of ether bridged bicyclic iminosugar derivatives. In: Carbohydrate Research. 2009 ; Vol. 344, No. 13. pp. 1639-1645.
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Synthesis and biological evaluation of ether bridged bicyclic iminosugar derivatives. / Chir, Jiun Ly; Wu, Pey Jiuann; Zou, Wei; Bhasin, Milan; Juang, Wei Fu; Guo, Chao Qi; Wu, An-Tai.

In: Carbohydrate Research, Vol. 344, No. 13, 08.09.2009, p. 1639-1645.

Research output: Contribution to journalArticle

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AU - Juang, Wei Fu

AU - Guo, Chao Qi

AU - Wu, An-Tai

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