Synthesis and biological evaluation of ether bridged bicyclic iminosugar derivatives

Jiun Ly Chir, Pey Jiuann Wu, Wei Zou, Milan Bhasin, Wei Fu Juang, Chao Qi Guo, An Tai Wu

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4 Citations (Scopus)

Abstract

Bicyclic iminosugar derivatives with an ether bridge bearing different substituents on C-2 and the nitrogen atom have been synthesized from a C-glycoside bearing an isopropylidene acetal. The activities of these compounds were investigated against several glycosidase enzymes and showed moderate inhibition and activation.

Original languageEnglish
Pages (from-to)1639-1645
Number of pages7
JournalCarbohydrate Research
Volume344
Issue number13
DOIs
Publication statusPublished - 2009 Sep 8

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All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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