Abstract
Bicyclic iminosugar derivatives with an ether bridge bearing different substituents on C-2 and the nitrogen atom have been synthesized from a C-glycoside bearing an isopropylidene acetal. The activities of these compounds were investigated against several glycosidase enzymes and showed moderate inhibition and activation.
| Original language | English |
|---|---|
| Pages (from-to) | 1639-1645 |
| Number of pages | 7 |
| Journal | Carbohydrate Research |
| Volume | 344 |
| Issue number | 13 |
| DOIs | |
| Publication status | Published - 2009 Sep 8 |
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All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Biochemistry
- Organic Chemistry
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Synthesis and biological evaluation of ether bridged bicyclic iminosugar derivatives. / Chir, Jiun Ly; Wu, Pey Jiuann; Zou, Wei; Bhasin, Milan; Juang, Wei Fu; Guo, Chao Qi; Wu, An Tai.
In: Carbohydrate Research, Vol. 344, No. 13, 08.09.2009, p. 1639-1645.Research output: Contribution to journal › Article
TY - JOUR
T1 - Synthesis and biological evaluation of ether bridged bicyclic iminosugar derivatives
AU - Chir, Jiun Ly
AU - Wu, Pey Jiuann
AU - Zou, Wei
AU - Bhasin, Milan
AU - Juang, Wei Fu
AU - Guo, Chao Qi
AU - Wu, An Tai
PY - 2009/9/8
Y1 - 2009/9/8
N2 - Bicyclic iminosugar derivatives with an ether bridge bearing different substituents on C-2 and the nitrogen atom have been synthesized from a C-glycoside bearing an isopropylidene acetal. The activities of these compounds were investigated against several glycosidase enzymes and showed moderate inhibition and activation.
AB - Bicyclic iminosugar derivatives with an ether bridge bearing different substituents on C-2 and the nitrogen atom have been synthesized from a C-glycoside bearing an isopropylidene acetal. The activities of these compounds were investigated against several glycosidase enzymes and showed moderate inhibition and activation.
UR - http://www.scopus.com/inward/record.url?scp=69149087853&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=69149087853&partnerID=8YFLogxK
U2 - 10.1016/j.carres.2009.05.029
DO - 10.1016/j.carres.2009.05.029
M3 - Article
C2 - 19570528
AN - SCOPUS:69149087853
VL - 344
SP - 1639
EP - 1645
JO - Carbohydrate Research
JF - Carbohydrate Research
SN - 0008-6215
IS - 13
ER -