Synthesis and biological evaluation of ether bridged bicyclic iminosugar derivatives

Jiun Ly Chir, Pey Jiuann Wu, Wei Zou, Milan Bhasin, Wei Fu Juang, Chao Qi Guo, An Tai Wu

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Bicyclic iminosugar derivatives with an ether bridge bearing different substituents on C-2 and the nitrogen atom have been synthesized from a C-glycoside bearing an isopropylidene acetal. The activities of these compounds were investigated against several glycosidase enzymes and showed moderate inhibition and activation.

Original languageEnglish
Pages (from-to)1639-1645
Number of pages7
JournalCarbohydrate Research
Volume344
Issue number13
DOIs
Publication statusPublished - 2009 Sep 8

Fingerprint

Bearings (structural)
Bridge bearings
Acetals
Glycoside Hydrolases
Ether
Nitrogen
Chemical activation
Derivatives
Atoms
Enzymes
propylene
C-glycoside

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

Cite this

Chir, Jiun Ly ; Wu, Pey Jiuann ; Zou, Wei ; Bhasin, Milan ; Juang, Wei Fu ; Guo, Chao Qi ; Wu, An Tai. / Synthesis and biological evaluation of ether bridged bicyclic iminosugar derivatives. In: Carbohydrate Research. 2009 ; Vol. 344, No. 13. pp. 1639-1645.
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Synthesis and biological evaluation of ether bridged bicyclic iminosugar derivatives. / Chir, Jiun Ly; Wu, Pey Jiuann; Zou, Wei; Bhasin, Milan; Juang, Wei Fu; Guo, Chao Qi; Wu, An Tai.

In: Carbohydrate Research, Vol. 344, No. 13, 08.09.2009, p. 1639-1645.

Research output: Contribution to journalArticle

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AU - Guo, Chao Qi

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