Sulfur-containing polybromoindoles from the formosan red alga Laurencia brongniartii

Ali A. El-Gamal; Wei Lung Wang; Chang Yih Duh

doi:10.1021/np058001y

Sulfur-containing polybromoindoles from the formosan red alga Laurencia brongniartii

Ali A. El-Gamal, Wei Lung Wang, Chang Yih Duh

Department of Biology

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

Five new sulfur-containing polybromoindoles, 2-methylsulfinyl-3-methylthio- 4,5,6-tribromoindole (1), 3-methylsulfinyl-2,4,6-tribromoindole (2), 4,6-dibromo-2,3-di(methylsulfinyl)indole (3), 3,3′-bis(2′- methylsulfinyl-2-methylthio-4,6,4′,6′-tetrabromo)indole (4), and 3,3-bis(4,6-dibromo-2-methylsulfinyl)indole (5), as well as seven known sulfur-containing polybromoindoles, 3-methylthio-2,4,6-tribromoindole (6), 3-methylthio-2,4,5,6-tetrabromoindole (7), 4,6-dibromo-2,3-di(methylthio)indole (8), 2,3-di(methylthio)-4,5,6-tribromoindole (9), 4,6-dibromo-2-methylsulfinyl- 3-(methylthio)indole (10), 4,6-dibromo-2-(methylthio)indole (11), and 3,3-bis(4,6-dibromo-2-methylthio)indole (12), have been isolated from the Formosan red alga Laurencia brongniartii. The structures were elucidated by extensive spectral analysis, and their cytotoxicity against selected cancer cells was measured in vitro.

Original language	English
Pages (from-to)	815-817
Number of pages	3
Journal	Journal of Natural Products
Volume	68
Issue number	5
DOIs	https://doi.org/10.1021/np058001y
Publication status	Published - 2005 May 1

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

Access to Document

10.1021/np058001y

Fingerprint Dive into the research topics of 'Sulfur-containing polybromoindoles from the formosan red alga Laurencia brongniartii'. Together they form a unique fingerprint.

Cite this

@article{811b980355134d99806c3b6fbf90a2ce,

title = "Sulfur-containing polybromoindoles from the formosan red alga Laurencia brongniartii",

abstract = "Five new sulfur-containing polybromoindoles, 2-methylsulfinyl-3-methylthio- 4,5,6-tribromoindole (1), 3-methylsulfinyl-2,4,6-tribromoindole (2), 4,6-dibromo-2,3-di(methylsulfinyl)indole (3), 3,3′-bis(2′- methylsulfinyl-2-methylthio-4,6,4′,6′-tetrabromo)indole (4), and 3,3-bis(4,6-dibromo-2-methylsulfinyl)indole (5), as well as seven known sulfur-containing polybromoindoles, 3-methylthio-2,4,6-tribromoindole (6), 3-methylthio-2,4,5,6-tetrabromoindole (7), 4,6-dibromo-2,3-di(methylthio)indole (8), 2,3-di(methylthio)-4,5,6-tribromoindole (9), 4,6-dibromo-2-methylsulfinyl- 3-(methylthio)indole (10), 4,6-dibromo-2-(methylthio)indole (11), and 3,3-bis(4,6-dibromo-2-methylthio)indole (12), have been isolated from the Formosan red alga Laurencia brongniartii. The structures were elucidated by extensive spectral analysis, and their cytotoxicity against selected cancer cells was measured in vitro.",

author = "El-Gamal, {Ali A.} and Wang, {Wei Lung} and Duh, {Chang Yih}",

year = "2005",

month = may,

day = "1",

doi = "10.1021/np058001y",

language = "English",

volume = "68",

pages = "815--817",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "5",

}

TY - JOUR

T1 - Sulfur-containing polybromoindoles from the formosan red alga Laurencia brongniartii

AU - El-Gamal, Ali A.

AU - Wang, Wei Lung

AU - Duh, Chang Yih

PY - 2005/5/1

Y1 - 2005/5/1

N2 - Five new sulfur-containing polybromoindoles, 2-methylsulfinyl-3-methylthio- 4,5,6-tribromoindole (1), 3-methylsulfinyl-2,4,6-tribromoindole (2), 4,6-dibromo-2,3-di(methylsulfinyl)indole (3), 3,3′-bis(2′- methylsulfinyl-2-methylthio-4,6,4′,6′-tetrabromo)indole (4), and 3,3-bis(4,6-dibromo-2-methylsulfinyl)indole (5), as well as seven known sulfur-containing polybromoindoles, 3-methylthio-2,4,6-tribromoindole (6), 3-methylthio-2,4,5,6-tetrabromoindole (7), 4,6-dibromo-2,3-di(methylthio)indole (8), 2,3-di(methylthio)-4,5,6-tribromoindole (9), 4,6-dibromo-2-methylsulfinyl- 3-(methylthio)indole (10), 4,6-dibromo-2-(methylthio)indole (11), and 3,3-bis(4,6-dibromo-2-methylthio)indole (12), have been isolated from the Formosan red alga Laurencia brongniartii. The structures were elucidated by extensive spectral analysis, and their cytotoxicity against selected cancer cells was measured in vitro.

AB - Five new sulfur-containing polybromoindoles, 2-methylsulfinyl-3-methylthio- 4,5,6-tribromoindole (1), 3-methylsulfinyl-2,4,6-tribromoindole (2), 4,6-dibromo-2,3-di(methylsulfinyl)indole (3), 3,3′-bis(2′- methylsulfinyl-2-methylthio-4,6,4′,6′-tetrabromo)indole (4), and 3,3-bis(4,6-dibromo-2-methylsulfinyl)indole (5), as well as seven known sulfur-containing polybromoindoles, 3-methylthio-2,4,6-tribromoindole (6), 3-methylthio-2,4,5,6-tetrabromoindole (7), 4,6-dibromo-2,3-di(methylthio)indole (8), 2,3-di(methylthio)-4,5,6-tribromoindole (9), 4,6-dibromo-2-methylsulfinyl- 3-(methylthio)indole (10), 4,6-dibromo-2-(methylthio)indole (11), and 3,3-bis(4,6-dibromo-2-methylthio)indole (12), have been isolated from the Formosan red alga Laurencia brongniartii. The structures were elucidated by extensive spectral analysis, and their cytotoxicity against selected cancer cells was measured in vitro.

UR - http://www.scopus.com/inward/record.url?scp=20444462044&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20444462044&partnerID=8YFLogxK

U2 - 10.1021/np058001y

DO - 10.1021/np058001y

M3 - Article

C2 - 15921441

AN - SCOPUS:20444462044

VL - 68

SP - 815

EP - 817

JO - Journal of Natural Products

JF - Journal of Natural Products

SN - 0163-3864

IS - 5

ER -