Sulfur-containing polybromoindoles from the formosan red alga Laurencia brongniartii

Ali A. El-Gamal, Wei Lung Wang, Chang Yih Duh

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Five new sulfur-containing polybromoindoles, 2-methylsulfinyl-3-methylthio- 4,5,6-tribromoindole (1), 3-methylsulfinyl-2,4,6-tribromoindole (2), 4,6-dibromo-2,3-di(methylsulfinyl)indole (3), 3,3′-bis(2′- methylsulfinyl-2-methylthio-4,6,4′,6′-tetrabromo)indole (4), and 3,3-bis(4,6-dibromo-2-methylsulfinyl)indole (5), as well as seven known sulfur-containing polybromoindoles, 3-methylthio-2,4,6-tribromoindole (6), 3-methylthio-2,4,5,6-tetrabromoindole (7), 4,6-dibromo-2,3-di(methylthio)indole (8), 2,3-di(methylthio)-4,5,6-tribromoindole (9), 4,6-dibromo-2-methylsulfinyl- 3-(methylthio)indole (10), 4,6-dibromo-2-(methylthio)indole (11), and 3,3-bis(4,6-dibromo-2-methylthio)indole (12), have been isolated from the Formosan red alga Laurencia brongniartii. The structures were elucidated by extensive spectral analysis, and their cytotoxicity against selected cancer cells was measured in vitro.

Original languageEnglish
Pages (from-to)815-817
Number of pages3
JournalJournal of Natural Products
Volume68
Issue number5
DOIs
Publication statusPublished - 2005 May 1

Fingerprint

Laurencia
Rhodophyta
Algae
Sulfur
Cytotoxicity
indole
Spectrum analysis
Cells

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

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title = "Sulfur-containing polybromoindoles from the formosan red alga Laurencia brongniartii",
abstract = "Five new sulfur-containing polybromoindoles, 2-methylsulfinyl-3-methylthio- 4,5,6-tribromoindole (1), 3-methylsulfinyl-2,4,6-tribromoindole (2), 4,6-dibromo-2,3-di(methylsulfinyl)indole (3), 3,3′-bis(2′- methylsulfinyl-2-methylthio-4,6,4′,6′-tetrabromo)indole (4), and 3,3-bis(4,6-dibromo-2-methylsulfinyl)indole (5), as well as seven known sulfur-containing polybromoindoles, 3-methylthio-2,4,6-tribromoindole (6), 3-methylthio-2,4,5,6-tetrabromoindole (7), 4,6-dibromo-2,3-di(methylthio)indole (8), 2,3-di(methylthio)-4,5,6-tribromoindole (9), 4,6-dibromo-2-methylsulfinyl- 3-(methylthio)indole (10), 4,6-dibromo-2-(methylthio)indole (11), and 3,3-bis(4,6-dibromo-2-methylthio)indole (12), have been isolated from the Formosan red alga Laurencia brongniartii. The structures were elucidated by extensive spectral analysis, and their cytotoxicity against selected cancer cells was measured in vitro.",
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Sulfur-containing polybromoindoles from the formosan red alga Laurencia brongniartii. / El-Gamal, Ali A.; Wang, Wei Lung; Duh, Chang Yih.

In: Journal of Natural Products, Vol. 68, No. 5, 01.05.2005, p. 815-817.

Research output: Contribution to journalArticle

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