In this paper, we investigated the failure mechanisms of blue InGaN LEDs grown on patterned sapphire substrates and demonstrated the influence of patterned sapphire substrates on the reliability of GaN LED by comparing with conventional LEDs grown on planar sapphire substrates. From experimental results, we found that InGaN LEDs grown on patterned substrates had a higher turn-on voltage but a smaller series resistance compared with conventional LEDs owing to rough inner patterns and small threading dislocation density. Both samples were then acceleratedly aged under a high DC current for two hours. Failure modes were studied with various measurements taken before and after aging. From the power evolution performance, we found that output power of LEDs with patterned substrates increased slightly due to fewer defects while output power of conventional LEDs decayed. This can be inferred from small reverse leakage currents and tunneling currents observed from Log I-V characteristics and EMMI measurement of P-LEDs. A slight redshift in emission wavelength was also found during aging because of possible leakage shunt paths caused by defect generation. Moreover, operation voltage increased slightly after aging which was caused by contact degradation induced by thermal annealing.