For establishment of the structure-activity relationship, 19 heterobicycle-coumarin conjugated compounds with the -SCH2- linker were synthesized and found to possess significant antiviral activities. Prominent examples included imidazopyridine-coumarin 12c, purine-coumarin 12d, and benzoxazole-coumarin 14c, which inhibited HCV replication at an EC 50 of 6.8, 2.0, and 12 μM, respectively. The heteroatoms in bicycles and the substituent effect on coumarin played essential roles.
All Science Journal Classification (ASJC) codes
- Molecular Medicine
- Drug Discovery