Structural characterization of cobalt(II) complexes of an N,O donor Schiff base and their activity on carcinoma cells

Kuheli Das, Amitabha Datta, Pei Hsin Liu, Jui Hsien Huang, Chin Lin Hsu, Wei Tang Chang, Barbara MacHura, Chittaranjan Sinha

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

2-[{[2-(Dimethylamino)ethyl]imino}methyl]-6-methoxyphenol (LH) is a potential tetradentate monoanionic N2O2 chelator; however, this precursor coordinates to cobalt(II) centres in two ways, as neutral bidentate-NO and as terdentate-N2O, along with a pseudohalide, like thiocyanate and azide, to afford [Co(LH)2(NCS)]NO3 (1) and [Co(LH)2(N3)]NO3 (2), respectively. Both the complexes are characterized by spectroscopic (IR, UV-Vis) analysis, thermal and redox studies. The room temperature magnetic moments for 1 and 2 are 4.91 and 4.93 B.M, respectively. Single crystal X-ray diffraction analysis confirms the distorted octahedral geometry around Co(II). These two complexes (1 and 2) inhibit the cell growth of human lung carcinoma cells (A549 cells), human colorectal carcinoma cells (COLO 205 cells), human hepatocellular carcinoma cells (PLC5 cells) and human fibroblasts cells (NIH3T3). Complex 2 shows a higher inhibitory activity, with 46.00 ± 1.09 μM IC50 in human colorectal carcinoma cells (COLO 205 cells).

Original languageEnglish
Pages (from-to)85-90
Number of pages6
JournalPolyhedron
Volume71
DOIs
Publication statusPublished - 2014 Mar 29

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Schiff Bases
Cobalt
imines
cobalt
cancer
Cells
cells
Azides
Cell growth
Fibroblasts
Chelating Agents
Magnetic moments
X ray diffraction analysis
Thermoanalysis
fibroblasts
lungs
Single crystals
thermal analysis
magnetic moments
Geometry

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

Cite this

Das, Kuheli ; Datta, Amitabha ; Liu, Pei Hsin ; Huang, Jui Hsien ; Hsu, Chin Lin ; Chang, Wei Tang ; MacHura, Barbara ; Sinha, Chittaranjan. / Structural characterization of cobalt(II) complexes of an N,O donor Schiff base and their activity on carcinoma cells. In: Polyhedron. 2014 ; Vol. 71. pp. 85-90.
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abstract = "2-[{[2-(Dimethylamino)ethyl]imino}methyl]-6-methoxyphenol (LH) is a potential tetradentate monoanionic N2O2 chelator; however, this precursor coordinates to cobalt(II) centres in two ways, as neutral bidentate-NO and as terdentate-N2O, along with a pseudohalide, like thiocyanate and azide, to afford [Co(LH)2(NCS)]NO3 (1) and [Co(LH)2(N3)]NO3 (2), respectively. Both the complexes are characterized by spectroscopic (IR, UV-Vis) analysis, thermal and redox studies. The room temperature magnetic moments for 1 and 2 are 4.91 and 4.93 B.M, respectively. Single crystal X-ray diffraction analysis confirms the distorted octahedral geometry around Co(II). These two complexes (1 and 2) inhibit the cell growth of human lung carcinoma cells (A549 cells), human colorectal carcinoma cells (COLO 205 cells), human hepatocellular carcinoma cells (PLC5 cells) and human fibroblasts cells (NIH3T3). Complex 2 shows a higher inhibitory activity, with 46.00 ± 1.09 μM IC50 in human colorectal carcinoma cells (COLO 205 cells).",
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Structural characterization of cobalt(II) complexes of an N,O donor Schiff base and their activity on carcinoma cells. / Das, Kuheli; Datta, Amitabha; Liu, Pei Hsin; Huang, Jui Hsien; Hsu, Chin Lin; Chang, Wei Tang; MacHura, Barbara; Sinha, Chittaranjan.

In: Polyhedron, Vol. 71, 29.03.2014, p. 85-90.

Research output: Contribution to journalArticle

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T1 - Structural characterization of cobalt(II) complexes of an N,O donor Schiff base and their activity on carcinoma cells

AU - Das, Kuheli

AU - Datta, Amitabha

AU - Liu, Pei Hsin

AU - Huang, Jui Hsien

AU - Hsu, Chin Lin

AU - Chang, Wei Tang

AU - MacHura, Barbara

AU - Sinha, Chittaranjan

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Y1 - 2014/3/29

N2 - 2-[{[2-(Dimethylamino)ethyl]imino}methyl]-6-methoxyphenol (LH) is a potential tetradentate monoanionic N2O2 chelator; however, this precursor coordinates to cobalt(II) centres in two ways, as neutral bidentate-NO and as terdentate-N2O, along with a pseudohalide, like thiocyanate and azide, to afford [Co(LH)2(NCS)]NO3 (1) and [Co(LH)2(N3)]NO3 (2), respectively. Both the complexes are characterized by spectroscopic (IR, UV-Vis) analysis, thermal and redox studies. The room temperature magnetic moments for 1 and 2 are 4.91 and 4.93 B.M, respectively. Single crystal X-ray diffraction analysis confirms the distorted octahedral geometry around Co(II). These two complexes (1 and 2) inhibit the cell growth of human lung carcinoma cells (A549 cells), human colorectal carcinoma cells (COLO 205 cells), human hepatocellular carcinoma cells (PLC5 cells) and human fibroblasts cells (NIH3T3). Complex 2 shows a higher inhibitory activity, with 46.00 ± 1.09 μM IC50 in human colorectal carcinoma cells (COLO 205 cells).

AB - 2-[{[2-(Dimethylamino)ethyl]imino}methyl]-6-methoxyphenol (LH) is a potential tetradentate monoanionic N2O2 chelator; however, this precursor coordinates to cobalt(II) centres in two ways, as neutral bidentate-NO and as terdentate-N2O, along with a pseudohalide, like thiocyanate and azide, to afford [Co(LH)2(NCS)]NO3 (1) and [Co(LH)2(N3)]NO3 (2), respectively. Both the complexes are characterized by spectroscopic (IR, UV-Vis) analysis, thermal and redox studies. The room temperature magnetic moments for 1 and 2 are 4.91 and 4.93 B.M, respectively. Single crystal X-ray diffraction analysis confirms the distorted octahedral geometry around Co(II). These two complexes (1 and 2) inhibit the cell growth of human lung carcinoma cells (A549 cells), human colorectal carcinoma cells (COLO 205 cells), human hepatocellular carcinoma cells (PLC5 cells) and human fibroblasts cells (NIH3T3). Complex 2 shows a higher inhibitory activity, with 46.00 ± 1.09 μM IC50 in human colorectal carcinoma cells (COLO 205 cells).

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