Structural characterization of cobalt(II) complexes of an N,O donor Schiff base and their activity on carcinoma cells

Kuheli Das, Amitabha Datta, Pei Hsin Liu, Jui Hsien Huang, Chin Lin Hsu, Wei Tang Chang, Barbara MacHura, Chittaranjan Sinha

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18 Citations (Scopus)

Abstract

2-[{[2-(Dimethylamino)ethyl]imino}methyl]-6-methoxyphenol (LH) is a potential tetradentate monoanionic N2O2 chelator; however, this precursor coordinates to cobalt(II) centres in two ways, as neutral bidentate-NO and as terdentate-N2O, along with a pseudohalide, like thiocyanate and azide, to afford [Co(LH)2(NCS)]NO3 (1) and [Co(LH)2(N3)]NO3 (2), respectively. Both the complexes are characterized by spectroscopic (IR, UV-Vis) analysis, thermal and redox studies. The room temperature magnetic moments for 1 and 2 are 4.91 and 4.93 B.M, respectively. Single crystal X-ray diffraction analysis confirms the distorted octahedral geometry around Co(II). These two complexes (1 and 2) inhibit the cell growth of human lung carcinoma cells (A549 cells), human colorectal carcinoma cells (COLO 205 cells), human hepatocellular carcinoma cells (PLC5 cells) and human fibroblasts cells (NIH3T3). Complex 2 shows a higher inhibitory activity, with 46.00 ± 1.09 μM IC50 in human colorectal carcinoma cells (COLO 205 cells).

Original languageEnglish
Pages (from-to)85-90
Number of pages6
JournalPolyhedron
Volume71
DOIs
Publication statusPublished - 2014 Mar 29

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All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

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