Radical-induced cis-trans isomerization of fatty acids: A theoretical study

Yu Zan Tzeng, Ching Han Hu

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Trans fatty acids (TFAs) create deleterious effects; thus their existence in humans is a great health concern. TFAs can be obtained through diet, or they can be formed endogenously by radical-induced cis to trans isomerization. The mechanism of isomerization of fatty acid catalyzed by radicals including nitrogen dioxide (NO2), thiyl (RS), and peroxide (ROO) radicals were investigated using density functional theory. With linoleic acid, a fatty acid consisting of two homoconjugated C=C bonds, we found that the radical addition mechanism is more favorable than the hydrogen abstraction mechanism. For all investigated radicals, the isomerization catalyzed by RS radical involves the smallest reaction barrier. We found that NO2 reactions through the N-terminus are more favorable than reactions through the O-terminus. The reaction barriers for NO2 catalyzed isomerizations were found to be lowered to a larger extent in polar solvent. β-carotene and lycopene were shown to protect fatty acids from isomerization by intercepting the isomerization-causing radicals.

Original languageEnglish
Pages (from-to)4554-4564
Number of pages11
JournalJournal of Physical Chemistry A
Volume118
Issue number25
DOIs
Publication statusPublished - 2014 Jun 26

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Trans Fatty Acids
fatty acids
Isomerization
isomerization
Fatty Acids
Nitrogen Dioxide
Peroxides
carotene
diets
Linoleic Acid
Carotenoids
Nutrition
nitrogen dioxide
peroxides
Density functional theory
Hydrogen
health
Health
density functional theory
acids

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry

Cite this

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Radical-induced cis-trans isomerization of fatty acids : A theoretical study. / Tzeng, Yu Zan; Hu, Ching Han.

In: Journal of Physical Chemistry A, Vol. 118, No. 25, 26.06.2014, p. 4554-4564.

Research output: Contribution to journalArticle

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AB - Trans fatty acids (TFAs) create deleterious effects; thus their existence in humans is a great health concern. TFAs can be obtained through diet, or they can be formed endogenously by radical-induced cis to trans isomerization. The mechanism of isomerization of fatty acid catalyzed by radicals including nitrogen dioxide (NO2•), thiyl (RS•), and peroxide (ROO•) radicals were investigated using density functional theory. With linoleic acid, a fatty acid consisting of two homoconjugated C=C bonds, we found that the radical addition mechanism is more favorable than the hydrogen abstraction mechanism. For all investigated radicals, the isomerization catalyzed by RS• radical involves the smallest reaction barrier. We found that NO2• reactions through the N-terminus are more favorable than reactions through the O-terminus. The reaction barriers for NO2• catalyzed isomerizations were found to be lowered to a larger extent in polar solvent. β-carotene and lycopene were shown to protect fatty acids from isomerization by intercepting the isomerization-causing radicals.

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