Abstract
Many phytoantioxidants have therapeutic drawbacks due to their potent prooxidant bioactivity. It is hypothesized that phytoantioxidants (PAO) are beneficial only to the early-stage diabetes mellitus (DM) and will become ineffective once renopathy occurs. Gallic acid, rutin, EGCG, ferulic acid (FA), and quercetin were tried on the streptozotocin (STZ)-induced DM rat model for a 28 week experimental period. All of these PAO were shown to be ineffective for hypoglycemic action. The incidence of cataract (50%), injured glomerules, and renal cell carcinoma (RCC) was very common, among which the most severely affected involved the quercetin- and the FA-treated groups. The tumorigenicity of ferulic acid is still unclear. However, for quercetin, this can be attributted to (i) the prooxidant effect, (ii) the insulin-secretagogue bioactivity, and (iii) the competitive and noncompetitive inhibition on the O-methyltransferase to enhance the estradiol-induced tumorigenesis. Conclusively, quercetin and FA are able to aggravate, if not induce, nephrocarcinoma. It is tie to reevaluate the tumorigenic detrimental effect of PAO, especially those exhibiting prooxidant bioactivity.
| Original language | English |
|---|---|
| Pages (from-to) | 9273-9280 |
| Number of pages | 8 |
| Journal | Journal of Agricultural and Food Chemistry |
| Volume | 58 |
| Issue number | 16 |
| DOIs | |
| Publication status | Published - 2010 Aug 25 |
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All Science Journal Classification (ASJC) codes
- Chemistry(all)
- Agricultural and Biological Sciences(all)
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Quercetin and ferulic acid aggravate renal carcinoma in long-term diabetic victims. / Hsieh, Chiu Lan; Peng, Chiung Chi; Cheng, Yu Ming; Lin, Li Yun; Ker, Yaw Bee; Chang, Chi Huang; Chen, Kuan Chou; Peng, Robert Y.
In: Journal of Agricultural and Food Chemistry, Vol. 58, No. 16, 25.08.2010, p. 9273-9280.Research output: Contribution to journal › Article
TY - JOUR
T1 - Quercetin and ferulic acid aggravate renal carcinoma in long-term diabetic victims
AU - Hsieh, Chiu Lan
AU - Peng, Chiung Chi
AU - Cheng, Yu Ming
AU - Lin, Li Yun
AU - Ker, Yaw Bee
AU - Chang, Chi Huang
AU - Chen, Kuan Chou
AU - Peng, Robert Y.
PY - 2010/8/25
Y1 - 2010/8/25
N2 - Many phytoantioxidants have therapeutic drawbacks due to their potent prooxidant bioactivity. It is hypothesized that phytoantioxidants (PAO) are beneficial only to the early-stage diabetes mellitus (DM) and will become ineffective once renopathy occurs. Gallic acid, rutin, EGCG, ferulic acid (FA), and quercetin were tried on the streptozotocin (STZ)-induced DM rat model for a 28 week experimental period. All of these PAO were shown to be ineffective for hypoglycemic action. The incidence of cataract (50%), injured glomerules, and renal cell carcinoma (RCC) was very common, among which the most severely affected involved the quercetin- and the FA-treated groups. The tumorigenicity of ferulic acid is still unclear. However, for quercetin, this can be attributted to (i) the prooxidant effect, (ii) the insulin-secretagogue bioactivity, and (iii) the competitive and noncompetitive inhibition on the O-methyltransferase to enhance the estradiol-induced tumorigenesis. Conclusively, quercetin and FA are able to aggravate, if not induce, nephrocarcinoma. It is tie to reevaluate the tumorigenic detrimental effect of PAO, especially those exhibiting prooxidant bioactivity.
AB - Many phytoantioxidants have therapeutic drawbacks due to their potent prooxidant bioactivity. It is hypothesized that phytoantioxidants (PAO) are beneficial only to the early-stage diabetes mellitus (DM) and will become ineffective once renopathy occurs. Gallic acid, rutin, EGCG, ferulic acid (FA), and quercetin were tried on the streptozotocin (STZ)-induced DM rat model for a 28 week experimental period. All of these PAO were shown to be ineffective for hypoglycemic action. The incidence of cataract (50%), injured glomerules, and renal cell carcinoma (RCC) was very common, among which the most severely affected involved the quercetin- and the FA-treated groups. The tumorigenicity of ferulic acid is still unclear. However, for quercetin, this can be attributted to (i) the prooxidant effect, (ii) the insulin-secretagogue bioactivity, and (iii) the competitive and noncompetitive inhibition on the O-methyltransferase to enhance the estradiol-induced tumorigenesis. Conclusively, quercetin and FA are able to aggravate, if not induce, nephrocarcinoma. It is tie to reevaluate the tumorigenic detrimental effect of PAO, especially those exhibiting prooxidant bioactivity.
UR - http://www.scopus.com/inward/record.url?scp=77956526508&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77956526508&partnerID=8YFLogxK
U2 - 10.1021/jf101580j
DO - 10.1021/jf101580j
M3 - Article
C2 - 20669956
AN - SCOPUS:77956526508
VL - 58
SP - 9273
EP - 9280
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
SN - 0021-8561
IS - 16
ER -