Quercetin and ferulic acid aggravate renal carcinoma in long-term diabetic victims

Chiu Lan Hsieh, Chiung Chi Peng, Yu Ming Cheng, Li Yun Lin, Yaw Bee Ker, Chi Huang Chang, Kuan Chou Chen, Robert Y. Peng

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Many phytoantioxidants have therapeutic drawbacks due to their potent prooxidant bioactivity. It is hypothesized that phytoantioxidants (PAO) are beneficial only to the early-stage diabetes mellitus (DM) and will become ineffective once renopathy occurs. Gallic acid, rutin, EGCG, ferulic acid (FA), and quercetin were tried on the streptozotocin (STZ)-induced DM rat model for a 28 week experimental period. All of these PAO were shown to be ineffective for hypoglycemic action. The incidence of cataract (50%), injured glomerules, and renal cell carcinoma (RCC) was very common, among which the most severely affected involved the quercetin- and the FA-treated groups. The tumorigenicity of ferulic acid is still unclear. However, for quercetin, this can be attributted to (i) the prooxidant effect, (ii) the insulin-secretagogue bioactivity, and (iii) the competitive and noncompetitive inhibition on the O-methyltransferase to enhance the estradiol-induced tumorigenesis. Conclusively, quercetin and FA are able to aggravate, if not induce, nephrocarcinoma. It is tie to reevaluate the tumorigenic detrimental effect of PAO, especially those exhibiting prooxidant bioactivity.

Original languageEnglish
Pages (from-to)9273-9280
Number of pages8
JournalJournal of Agricultural and Food Chemistry
Volume58
Issue number16
DOIs
Publication statusPublished - 2010 Aug 25

Fingerprint

ferulic acid
Quercetin
quercetin
carcinoma
Bioactivity
kidneys
Carcinoma
Kidney
Medical problems
diabetes mellitus
Diabetes Mellitus
Rutin
Gallic Acid
Experimental Diabetes Mellitus
cataract
streptozotocin
methyltransferases
Methyltransferases
rutin
kidney cells

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)

Cite this

Hsieh, C. L., Peng, C. C., Cheng, Y. M., Lin, L. Y., Ker, Y. B., Chang, C. H., ... Peng, R. Y. (2010). Quercetin and ferulic acid aggravate renal carcinoma in long-term diabetic victims. Journal of Agricultural and Food Chemistry, 58(16), 9273-9280. https://doi.org/10.1021/jf101580j
Hsieh, Chiu Lan ; Peng, Chiung Chi ; Cheng, Yu Ming ; Lin, Li Yun ; Ker, Yaw Bee ; Chang, Chi Huang ; Chen, Kuan Chou ; Peng, Robert Y. / Quercetin and ferulic acid aggravate renal carcinoma in long-term diabetic victims. In: Journal of Agricultural and Food Chemistry. 2010 ; Vol. 58, No. 16. pp. 9273-9280.
@article{6570ff6edf3a412aa2bc1286be5302ae,
title = "Quercetin and ferulic acid aggravate renal carcinoma in long-term diabetic victims",
abstract = "Many phytoantioxidants have therapeutic drawbacks due to their potent prooxidant bioactivity. It is hypothesized that phytoantioxidants (PAO) are beneficial only to the early-stage diabetes mellitus (DM) and will become ineffective once renopathy occurs. Gallic acid, rutin, EGCG, ferulic acid (FA), and quercetin were tried on the streptozotocin (STZ)-induced DM rat model for a 28 week experimental period. All of these PAO were shown to be ineffective for hypoglycemic action. The incidence of cataract (50{\%}), injured glomerules, and renal cell carcinoma (RCC) was very common, among which the most severely affected involved the quercetin- and the FA-treated groups. The tumorigenicity of ferulic acid is still unclear. However, for quercetin, this can be attributted to (i) the prooxidant effect, (ii) the insulin-secretagogue bioactivity, and (iii) the competitive and noncompetitive inhibition on the O-methyltransferase to enhance the estradiol-induced tumorigenesis. Conclusively, quercetin and FA are able to aggravate, if not induce, nephrocarcinoma. It is tie to reevaluate the tumorigenic detrimental effect of PAO, especially those exhibiting prooxidant bioactivity.",
author = "Hsieh, {Chiu Lan} and Peng, {Chiung Chi} and Cheng, {Yu Ming} and Lin, {Li Yun} and Ker, {Yaw Bee} and Chang, {Chi Huang} and Chen, {Kuan Chou} and Peng, {Robert Y.}",
year = "2010",
month = "8",
day = "25",
doi = "10.1021/jf101580j",
language = "English",
volume = "58",
pages = "9273--9280",
journal = "Journal of Agricultural and Food Chemistry",
issn = "0021-8561",
publisher = "American Chemical Society",
number = "16",

}

Hsieh, CL, Peng, CC, Cheng, YM, Lin, LY, Ker, YB, Chang, CH, Chen, KC & Peng, RY 2010, 'Quercetin and ferulic acid aggravate renal carcinoma in long-term diabetic victims', Journal of Agricultural and Food Chemistry, vol. 58, no. 16, pp. 9273-9280. https://doi.org/10.1021/jf101580j

Quercetin and ferulic acid aggravate renal carcinoma in long-term diabetic victims. / Hsieh, Chiu Lan; Peng, Chiung Chi; Cheng, Yu Ming; Lin, Li Yun; Ker, Yaw Bee; Chang, Chi Huang; Chen, Kuan Chou; Peng, Robert Y.

In: Journal of Agricultural and Food Chemistry, Vol. 58, No. 16, 25.08.2010, p. 9273-9280.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Quercetin and ferulic acid aggravate renal carcinoma in long-term diabetic victims

AU - Hsieh, Chiu Lan

AU - Peng, Chiung Chi

AU - Cheng, Yu Ming

AU - Lin, Li Yun

AU - Ker, Yaw Bee

AU - Chang, Chi Huang

AU - Chen, Kuan Chou

AU - Peng, Robert Y.

PY - 2010/8/25

Y1 - 2010/8/25

N2 - Many phytoantioxidants have therapeutic drawbacks due to their potent prooxidant bioactivity. It is hypothesized that phytoantioxidants (PAO) are beneficial only to the early-stage diabetes mellitus (DM) and will become ineffective once renopathy occurs. Gallic acid, rutin, EGCG, ferulic acid (FA), and quercetin were tried on the streptozotocin (STZ)-induced DM rat model for a 28 week experimental period. All of these PAO were shown to be ineffective for hypoglycemic action. The incidence of cataract (50%), injured glomerules, and renal cell carcinoma (RCC) was very common, among which the most severely affected involved the quercetin- and the FA-treated groups. The tumorigenicity of ferulic acid is still unclear. However, for quercetin, this can be attributted to (i) the prooxidant effect, (ii) the insulin-secretagogue bioactivity, and (iii) the competitive and noncompetitive inhibition on the O-methyltransferase to enhance the estradiol-induced tumorigenesis. Conclusively, quercetin and FA are able to aggravate, if not induce, nephrocarcinoma. It is tie to reevaluate the tumorigenic detrimental effect of PAO, especially those exhibiting prooxidant bioactivity.

AB - Many phytoantioxidants have therapeutic drawbacks due to their potent prooxidant bioactivity. It is hypothesized that phytoantioxidants (PAO) are beneficial only to the early-stage diabetes mellitus (DM) and will become ineffective once renopathy occurs. Gallic acid, rutin, EGCG, ferulic acid (FA), and quercetin were tried on the streptozotocin (STZ)-induced DM rat model for a 28 week experimental period. All of these PAO were shown to be ineffective for hypoglycemic action. The incidence of cataract (50%), injured glomerules, and renal cell carcinoma (RCC) was very common, among which the most severely affected involved the quercetin- and the FA-treated groups. The tumorigenicity of ferulic acid is still unclear. However, for quercetin, this can be attributted to (i) the prooxidant effect, (ii) the insulin-secretagogue bioactivity, and (iii) the competitive and noncompetitive inhibition on the O-methyltransferase to enhance the estradiol-induced tumorigenesis. Conclusively, quercetin and FA are able to aggravate, if not induce, nephrocarcinoma. It is tie to reevaluate the tumorigenic detrimental effect of PAO, especially those exhibiting prooxidant bioactivity.

UR - http://www.scopus.com/inward/record.url?scp=77956526508&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956526508&partnerID=8YFLogxK

U2 - 10.1021/jf101580j

DO - 10.1021/jf101580j

M3 - Article

C2 - 20669956

AN - SCOPUS:77956526508

VL - 58

SP - 9273

EP - 9280

JO - Journal of Agricultural and Food Chemistry

JF - Journal of Agricultural and Food Chemistry

SN - 0021-8561

IS - 16

ER -