Quantification of dendrimer nanoparticle targeting on tumor cells by two-photon excitation fluorescence through a dual-clad optical fiber

Yu Chung Chang, Thommey P. Thomas, Jing Yong Ye, Alina Kotlyar, Zhengyi Cao, Istvan J. Majoros, James R. Baker, Theodore B. Norris

Research output: Contribution to conferencePaper

Abstract

We report the use of a dual-clad optical fiber to conduct quantitative two-photon excited fluorescence measurements in vitro and in vivo inside tumors. The ability to detect nanomolar concentrations of tumor cell targeting nanoparticles with this dual-clad fiber scheme is confirmed. The results indicate that this technique is an appropriate tool to quantify low concentrations of targeted fluorescence probes in vivo in deep tissue.

Original languageEnglish
PagesBSuE4
DOIs
Publication statusPublished - 2008
EventBiomedical Optics, BIOMED 2008 - St. Petersburg, FL, United States
Duration: 2008 Mar 162008 Mar 19

Other

OtherBiomedical Optics, BIOMED 2008
CountryUnited States
CitySt. Petersburg, FL
Period08-03-1608-03-19

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

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    Chang, Y. C., Thomas, T. P., Ye, J. Y., Kotlyar, A., Cao, Z., Majoros, I. J., Baker, J. R., & Norris, T. B. (2008). Quantification of dendrimer nanoparticle targeting on tumor cells by two-photon excitation fluorescence through a dual-clad optical fiber. BSuE4. Paper presented at Biomedical Optics, BIOMED 2008, St. Petersburg, FL, United States. https://doi.org/10.1364/biomed.2008.bsue4