Progression of precancerous lesions to oral cancer: Results based on the Taiwan National Health Insurance Database

Ie Bin Lian, Yao Ting Tseng, Che Chun Su, Kuo Yang Tsai

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Background: Oral cancer (OC) is the leading cause of death from cancer in men between the ages of 25 and 44 in Taiwan. The survival rate for the last stage of OC is <20% while that for the earliest stage is >75%, which suggests the importance of the diagnosis of oral precancerous lesions (OPLs) in reducing OC mortality. The aim of this study was to analyze the time to OC event after OPL diagnosis, and to suggest the surveillance period necessary according to OPL type. Materials and methods: This was a retrospective cohort study based on 1.0 million people randomly selected from the Taiwan National Health Insurance Database, which provided data on 3058 adult male patients aged ≥20 years who were diagnosed with OPL for the first time between 1996 and 2009. The patient population was divided into two groups according to the type of lesion: oral submucous fibrosis (OSF) or oral leukoplakia (OLE). Age-standardized incidence rate (ASIR) and hazards rate (HR) were then estimated. Results: The ASIR for OPL showed an increasing trend over the study period, the main contributor to this being OSF. The OSF group demonstrated a higher OC incidence rate than the OLE group. Conclusion: Patients with both OLE and OSF carry a higher risk for OC than those with either OLE or OSF alone, and they may also experience malignant transformation at an earlier date (mostly within 5 years). The 5- and 10-year OC rate for both OLE and OSF was found to be 5% and around 10%, respectively. However, 10 years after the diagnosis of OPL, OSF carries a higher risk of developing into OC than OLE.

Original languageEnglish
Pages (from-to)427-430
Number of pages4
JournalOral Oncology
Volume49
Issue number5
DOIs
Publication statusPublished - 2013 May 1

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Oral Submucous Fibrosis
Mouth Neoplasms
National Health Programs
Taiwan
Oral Leukoplakia
Databases
Oral Diagnosis
Incidence
Cause of Death
Cohort Studies
Survival Rate
Retrospective Studies
Mortality

All Science Journal Classification (ASJC) codes

  • Oncology
  • Oral Surgery
  • Cancer Research

Cite this

Lian, Ie Bin ; Tseng, Yao Ting ; Su, Che Chun ; Tsai, Kuo Yang. / Progression of precancerous lesions to oral cancer : Results based on the Taiwan National Health Insurance Database. In: Oral Oncology. 2013 ; Vol. 49, No. 5. pp. 427-430.
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abstract = "Background: Oral cancer (OC) is the leading cause of death from cancer in men between the ages of 25 and 44 in Taiwan. The survival rate for the last stage of OC is <20{\%} while that for the earliest stage is >75{\%}, which suggests the importance of the diagnosis of oral precancerous lesions (OPLs) in reducing OC mortality. The aim of this study was to analyze the time to OC event after OPL diagnosis, and to suggest the surveillance period necessary according to OPL type. Materials and methods: This was a retrospective cohort study based on 1.0 million people randomly selected from the Taiwan National Health Insurance Database, which provided data on 3058 adult male patients aged ≥20 years who were diagnosed with OPL for the first time between 1996 and 2009. The patient population was divided into two groups according to the type of lesion: oral submucous fibrosis (OSF) or oral leukoplakia (OLE). Age-standardized incidence rate (ASIR) and hazards rate (HR) were then estimated. Results: The ASIR for OPL showed an increasing trend over the study period, the main contributor to this being OSF. The OSF group demonstrated a higher OC incidence rate than the OLE group. Conclusion: Patients with both OLE and OSF carry a higher risk for OC than those with either OLE or OSF alone, and they may also experience malignant transformation at an earlier date (mostly within 5 years). The 5- and 10-year OC rate for both OLE and OSF was found to be 5{\%} and around 10{\%}, respectively. However, 10 years after the diagnosis of OPL, OSF carries a higher risk of developing into OC than OLE.",
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Progression of precancerous lesions to oral cancer : Results based on the Taiwan National Health Insurance Database. / Lian, Ie Bin; Tseng, Yao Ting; Su, Che Chun; Tsai, Kuo Yang.

In: Oral Oncology, Vol. 49, No. 5, 01.05.2013, p. 427-430.

Research output: Contribution to journalArticle

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