Possible association between nickel and chromium and oral cancer

A case-control study in central Taiwan

Tzu Hsuen Yuan, Iebin Lian, Kuo Yang Tsai, Tsun Kuo Chang, Chi Ting Chiang, Che Chun Su, Yaw Huei Hwang

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Oral cancer is one of the most common cancers in Taiwan. Changhua County, in central Taiwan, has an extremely high prevalence of oral cancer, along with a high concentration of metal-related industries and soil metal contamination. The aim of this study was to clarify the possible association between metals and oral cancer within this specific area. This study recruited 101 oral cancer patients and 104 controls from the Changhua Christian Hospital. All subjects completed a questionnaire that asked about demographic information; cigarette, alcohol, and betel quid use; and environmental and occupational exposure history. Blood samples were collected and tested for metal concentrations with inductively coupled plasma mass spectrometry. A multiple logistic regression model illustrated that oral cancer was significantly associated with the blood levels of nickel and chromium (both with P< 0.0001) after controlling for potential confounders. This study suggested a potential role of these two metals in the mechanism of oral cancer development.

Original languageEnglish
Pages (from-to)1046-1052
Number of pages7
JournalScience of the Total Environment
Volume409
Issue number6
DOIs
Publication statusPublished - 2011 Feb 15

Fingerprint

Chromium
Nickel
chromium
cancer
nickel
Metals
metal
Blood
Inductively coupled plasma mass spectrometry
blood
Tobacco Products
Logistics
Alcohols
Contamination
occupational exposure
Soils
alcohol
logistics
mass spectrometry
plasma

All Science Journal Classification (ASJC) codes

  • Environmental Engineering
  • Environmental Chemistry
  • Waste Management and Disposal
  • Pollution

Cite this

Yuan, Tzu Hsuen ; Lian, Iebin ; Tsai, Kuo Yang ; Chang, Tsun Kuo ; Chiang, Chi Ting ; Su, Che Chun ; Hwang, Yaw Huei. / Possible association between nickel and chromium and oral cancer : A case-control study in central Taiwan. In: Science of the Total Environment. 2011 ; Vol. 409, No. 6. pp. 1046-1052.
@article{54a7b386bbac40b5b58cc700056e2f4b,
title = "Possible association between nickel and chromium and oral cancer: A case-control study in central Taiwan",
abstract = "Oral cancer is one of the most common cancers in Taiwan. Changhua County, in central Taiwan, has an extremely high prevalence of oral cancer, along with a high concentration of metal-related industries and soil metal contamination. The aim of this study was to clarify the possible association between metals and oral cancer within this specific area. This study recruited 101 oral cancer patients and 104 controls from the Changhua Christian Hospital. All subjects completed a questionnaire that asked about demographic information; cigarette, alcohol, and betel quid use; and environmental and occupational exposure history. Blood samples were collected and tested for metal concentrations with inductively coupled plasma mass spectrometry. A multiple logistic regression model illustrated that oral cancer was significantly associated with the blood levels of nickel and chromium (both with P< 0.0001) after controlling for potential confounders. This study suggested a potential role of these two metals in the mechanism of oral cancer development.",
author = "Yuan, {Tzu Hsuen} and Iebin Lian and Tsai, {Kuo Yang} and Chang, {Tsun Kuo} and Chiang, {Chi Ting} and Su, {Che Chun} and Hwang, {Yaw Huei}",
year = "2011",
month = "2",
day = "15",
doi = "10.1016/j.scitotenv.2010.11.038",
language = "English",
volume = "409",
pages = "1046--1052",
journal = "Science of the Total Environment",
issn = "0048-9697",
publisher = "Elsevier",
number = "6",

}

Possible association between nickel and chromium and oral cancer : A case-control study in central Taiwan. / Yuan, Tzu Hsuen; Lian, Iebin; Tsai, Kuo Yang; Chang, Tsun Kuo; Chiang, Chi Ting; Su, Che Chun; Hwang, Yaw Huei.

In: Science of the Total Environment, Vol. 409, No. 6, 15.02.2011, p. 1046-1052.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Possible association between nickel and chromium and oral cancer

T2 - A case-control study in central Taiwan

AU - Yuan, Tzu Hsuen

AU - Lian, Iebin

AU - Tsai, Kuo Yang

AU - Chang, Tsun Kuo

AU - Chiang, Chi Ting

AU - Su, Che Chun

AU - Hwang, Yaw Huei

PY - 2011/2/15

Y1 - 2011/2/15

N2 - Oral cancer is one of the most common cancers in Taiwan. Changhua County, in central Taiwan, has an extremely high prevalence of oral cancer, along with a high concentration of metal-related industries and soil metal contamination. The aim of this study was to clarify the possible association between metals and oral cancer within this specific area. This study recruited 101 oral cancer patients and 104 controls from the Changhua Christian Hospital. All subjects completed a questionnaire that asked about demographic information; cigarette, alcohol, and betel quid use; and environmental and occupational exposure history. Blood samples were collected and tested for metal concentrations with inductively coupled plasma mass spectrometry. A multiple logistic regression model illustrated that oral cancer was significantly associated with the blood levels of nickel and chromium (both with P< 0.0001) after controlling for potential confounders. This study suggested a potential role of these two metals in the mechanism of oral cancer development.

AB - Oral cancer is one of the most common cancers in Taiwan. Changhua County, in central Taiwan, has an extremely high prevalence of oral cancer, along with a high concentration of metal-related industries and soil metal contamination. The aim of this study was to clarify the possible association between metals and oral cancer within this specific area. This study recruited 101 oral cancer patients and 104 controls from the Changhua Christian Hospital. All subjects completed a questionnaire that asked about demographic information; cigarette, alcohol, and betel quid use; and environmental and occupational exposure history. Blood samples were collected and tested for metal concentrations with inductively coupled plasma mass spectrometry. A multiple logistic regression model illustrated that oral cancer was significantly associated with the blood levels of nickel and chromium (both with P< 0.0001) after controlling for potential confounders. This study suggested a potential role of these two metals in the mechanism of oral cancer development.

UR - http://www.scopus.com/inward/record.url?scp=78751705935&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78751705935&partnerID=8YFLogxK

U2 - 10.1016/j.scitotenv.2010.11.038

DO - 10.1016/j.scitotenv.2010.11.038

M3 - Article

VL - 409

SP - 1046

EP - 1052

JO - Science of the Total Environment

JF - Science of the Total Environment

SN - 0048-9697

IS - 6

ER -