Abstract
A photoacoustic correlation spectroscopy (PACS) technique was proposed for the first time. This technique is inspired by its optical counterpart-the fluorescence correlation spectroscopy (FCS), which is widely used in the characterization of the dynamics of fluorescent species. The fluorescence intensity is measured in FCS while the acoustic signals are detected in PACS. To proof of concept, we demonstrated the flow measurement of light-absorbing beads probed by a pulsed laser. A PACS system with temporal resolution of 0.8 sec was built. Polymer microring resonators were used to detect the photoacoustic signals, which were then signal processed and used to obtain the autocorrelation curves. Flow speeds ranging from 249 to 15.1 μm/s with corresponding flow time from 4.42 to 72.5 sec were measured. The capability of low-speed flow measurement can potentially be used for detecting blood flow in relatively deep capillaries in biological tissues. Moreover, similar to FCS, PACS may have many potential applications in studying the dynamics of photoacoustic beads.
| Original language | English |
|---|---|
| Title of host publication | Photons Plus Ultrasound |
| Subtitle of host publication | Imaging and Sensing 2010 |
| Volume | 7564 |
| DOIs | |
| Publication status | Published - 2010 May 3 |
| Event | Photons Plus Ultrasound: Imaging and Sensing 2010 - San Francisco, CA, United States Duration: 2010 Jan 24 → 2010 Jan 26 |
Other
| Other | Photons Plus Ultrasound: Imaging and Sensing 2010 |
|---|---|
| Country | United States |
| City | San Francisco, CA |
| Period | 10-01-24 → 10-01-26 |
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All Science Journal Classification (ASJC) codes
- Atomic and Molecular Physics, and Optics
- Electronic, Optical and Magnetic Materials
- Biomaterials
- Radiology Nuclear Medicine and imaging
Cite this
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Photoacoustic correlation technique for low-speed flow measurement. / Chen, Sung Liang; Ling, Tao; Huang, Sheng Wen; Baac, Hyoung Won; Chang, Yu-Chung; Guo, L. Jay.
Photons Plus Ultrasound: Imaging and Sensing 2010. Vol. 7564 2010. 75642I.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
TY - GEN
T1 - Photoacoustic correlation technique for low-speed flow measurement
AU - Chen, Sung Liang
AU - Ling, Tao
AU - Huang, Sheng Wen
AU - Baac, Hyoung Won
AU - Chang, Yu-Chung
AU - Guo, L. Jay
PY - 2010/5/3
Y1 - 2010/5/3
N2 - A photoacoustic correlation spectroscopy (PACS) technique was proposed for the first time. This technique is inspired by its optical counterpart-the fluorescence correlation spectroscopy (FCS), which is widely used in the characterization of the dynamics of fluorescent species. The fluorescence intensity is measured in FCS while the acoustic signals are detected in PACS. To proof of concept, we demonstrated the flow measurement of light-absorbing beads probed by a pulsed laser. A PACS system with temporal resolution of 0.8 sec was built. Polymer microring resonators were used to detect the photoacoustic signals, which were then signal processed and used to obtain the autocorrelation curves. Flow speeds ranging from 249 to 15.1 μm/s with corresponding flow time from 4.42 to 72.5 sec were measured. The capability of low-speed flow measurement can potentially be used for detecting blood flow in relatively deep capillaries in biological tissues. Moreover, similar to FCS, PACS may have many potential applications in studying the dynamics of photoacoustic beads.
AB - A photoacoustic correlation spectroscopy (PACS) technique was proposed for the first time. This technique is inspired by its optical counterpart-the fluorescence correlation spectroscopy (FCS), which is widely used in the characterization of the dynamics of fluorescent species. The fluorescence intensity is measured in FCS while the acoustic signals are detected in PACS. To proof of concept, we demonstrated the flow measurement of light-absorbing beads probed by a pulsed laser. A PACS system with temporal resolution of 0.8 sec was built. Polymer microring resonators were used to detect the photoacoustic signals, which were then signal processed and used to obtain the autocorrelation curves. Flow speeds ranging from 249 to 15.1 μm/s with corresponding flow time from 4.42 to 72.5 sec were measured. The capability of low-speed flow measurement can potentially be used for detecting blood flow in relatively deep capillaries in biological tissues. Moreover, similar to FCS, PACS may have many potential applications in studying the dynamics of photoacoustic beads.
UR - http://www.scopus.com/inward/record.url?scp=77951604642&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77951604642&partnerID=8YFLogxK
U2 - 10.1117/12.840123
DO - 10.1117/12.840123
M3 - Conference contribution
AN - SCOPUS:77951604642
SN - 9780819479600
VL - 7564
BT - Photons Plus Ultrasound
ER -