Abstract
Various (heterocyclo)carbonyl mono-oxime esters of anthraquinone were synthesized, which exhibited an ability for DNA cleavage upon UV irradiation. Their structure-activity relationship was established, in which the most potent compound was anthraquinone O-9-(1,3-benzothiazole-2-carbonyl)oxime (4j). It can produce radical species and nick DNA at the concentration as low as 1.0 μM.
Original language | English |
---|---|
Pages (from-to) | 3312-3315 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 49 |
Issue number | 20 |
DOIs | |
Publication status | Published - 2008 May 12 |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Drug Discovery
- Organic Chemistry