Photo-induced DNA cleavage by (heterocyclo)carbonyl oxime esters of anthraquinone

Jih Ru Hwu, Jhih Ren Yang, Shwu Chen Tsay, Ming Hua Hsu, Yi Chieh Chen, Shang Shing P. Chou

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Various (heterocyclo)carbonyl mono-oxime esters of anthraquinone were synthesized, which exhibited an ability for DNA cleavage upon UV irradiation. Their structure-activity relationship was established, in which the most potent compound was anthraquinone O-9-(1,3-benzothiazole-2-carbonyl)oxime (4j). It can produce radical species and nick DNA at the concentration as low as 1.0 μM.

Original languageEnglish
Pages (from-to)3312-3315
Number of pages4
JournalTetrahedron Letters
Volume49
Issue number20
DOIs
Publication statusPublished - 2008 May 12

Fingerprint

Anthraquinones
DNA Cleavage
Oximes
Esters
Single-Stranded DNA Breaks
DNA
Structure-Activity Relationship
Irradiation
benzothiazole

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Hwu, Jih Ru ; Yang, Jhih Ren ; Tsay, Shwu Chen ; Hsu, Ming Hua ; Chen, Yi Chieh ; Chou, Shang Shing P. / Photo-induced DNA cleavage by (heterocyclo)carbonyl oxime esters of anthraquinone. In: Tetrahedron Letters. 2008 ; Vol. 49, No. 20. pp. 3312-3315.
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Photo-induced DNA cleavage by (heterocyclo)carbonyl oxime esters of anthraquinone. / Hwu, Jih Ru; Yang, Jhih Ren; Tsay, Shwu Chen; Hsu, Ming Hua; Chen, Yi Chieh; Chou, Shang Shing P.

In: Tetrahedron Letters, Vol. 49, No. 20, 12.05.2008, p. 3312-3315.

Research output: Contribution to journalArticle

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AU - Chen, Yi Chieh

AU - Chou, Shang Shing P.

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