Abstract
Various (heterocyclo)carbonyl mono-oxime esters of anthraquinone were synthesized, which exhibited an ability for DNA cleavage upon UV irradiation. Their structure-activity relationship was established, in which the most potent compound was anthraquinone O-9-(1,3-benzothiazole-2-carbonyl)oxime (4j). It can produce radical species and nick DNA at the concentration as low as 1.0 μM.
| Original language | English |
|---|---|
| Pages (from-to) | 3312-3315 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 49 |
| Issue number | 20 |
| DOIs | |
| Publication status | Published - 2008 May 12 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Drug Discovery
- Organic Chemistry
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Photo-induced DNA cleavage by (heterocyclo)carbonyl oxime esters of anthraquinone. / Hwu, Jih Ru; Yang, Jhih Ren; Tsay, Shwu Chen; Hsu, Ming-Hua; Chen, Yi Chieh; Chou, Shang Shing P.
In: Tetrahedron Letters, Vol. 49, No. 20, 12.05.2008, p. 3312-3315.Research output: Contribution to journal › Article
TY - JOUR
T1 - Photo-induced DNA cleavage by (heterocyclo)carbonyl oxime esters of anthraquinone
AU - Hwu, Jih Ru
AU - Yang, Jhih Ren
AU - Tsay, Shwu Chen
AU - Hsu, Ming-Hua
AU - Chen, Yi Chieh
AU - Chou, Shang Shing P.
PY - 2008/5/12
Y1 - 2008/5/12
N2 - Various (heterocyclo)carbonyl mono-oxime esters of anthraquinone were synthesized, which exhibited an ability for DNA cleavage upon UV irradiation. Their structure-activity relationship was established, in which the most potent compound was anthraquinone O-9-(1,3-benzothiazole-2-carbonyl)oxime (4j). It can produce radical species and nick DNA at the concentration as low as 1.0 μM.
AB - Various (heterocyclo)carbonyl mono-oxime esters of anthraquinone were synthesized, which exhibited an ability for DNA cleavage upon UV irradiation. Their structure-activity relationship was established, in which the most potent compound was anthraquinone O-9-(1,3-benzothiazole-2-carbonyl)oxime (4j). It can produce radical species and nick DNA at the concentration as low as 1.0 μM.
UR - http://www.scopus.com/inward/record.url?scp=41949128611&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=41949128611&partnerID=8YFLogxK
U2 - 10.1016/j.tetlet.2008.03.056
DO - 10.1016/j.tetlet.2008.03.056
M3 - Article
VL - 49
SP - 3312
EP - 3315
JO - Tetrahedron Letters
JF - Tetrahedron Letters
SN - 0040-4039
IS - 20
ER -