Pd(0)-catalyzed decarboxylative coupling and tandem C-H arylation/decarboxylation for the synthesis of heteroaromatic biaryls

Debkumar Nandi, Yang Ming Jhou, Jhen Yi Lee, Bing Chiuan Kuo, Chien Yu Liu, Pei Wen Huang, Hon Man Lee

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

An effective Pd(0) carbene complex was successfully employed in the decarboxylative coupling of the heteroaromatic carboxylic acids (imidazo[1,2-a]pyridine and isoxazole) with aryl halides. For carboxyindoles, either decarboxylative coupling or tandem C-H arylation and decarboxylation occurred, leading to the formation of C2-monoarylated indoles.

Original languageEnglish
Pages (from-to)9384-9390
Number of pages7
JournalJournal of Organic Chemistry
Volume77
Issue number20
DOIs
Publication statusPublished - 2012 Oct 19

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Isoxazoles
Indoles
Carboxylic Acids
imidazo(1,2-a)pyridine
Decarboxylation
carbene

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

Cite this

Nandi, Debkumar ; Jhou, Yang Ming ; Lee, Jhen Yi ; Kuo, Bing Chiuan ; Liu, Chien Yu ; Huang, Pei Wen ; Lee, Hon Man. / Pd(0)-catalyzed decarboxylative coupling and tandem C-H arylation/decarboxylation for the synthesis of heteroaromatic biaryls. In: Journal of Organic Chemistry. 2012 ; Vol. 77, No. 20. pp. 9384-9390.
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Pd(0)-catalyzed decarboxylative coupling and tandem C-H arylation/decarboxylation for the synthesis of heteroaromatic biaryls. / Nandi, Debkumar; Jhou, Yang Ming; Lee, Jhen Yi; Kuo, Bing Chiuan; Liu, Chien Yu; Huang, Pei Wen; Lee, Hon Man.

In: Journal of Organic Chemistry, Vol. 77, No. 20, 19.10.2012, p. 9384-9390.

Research output: Contribution to journalArticle

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AU - Lee, Hon Man

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