Pd(0)-catalyzed decarboxylative coupling and tandem C-H arylation/decarboxylation for the synthesis of heteroaromatic biaryls

Debkumar Nandi, Yang Ming Jhou, Jhen Yi Lee, Bing Chiuan Kuo, Chien Yu Liu, Pei Wen Huang, Hon Man Lee

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Abstract

An effective Pd(0) carbene complex was successfully employed in the decarboxylative coupling of the heteroaromatic carboxylic acids (imidazo[1,2-a]pyridine and isoxazole) with aryl halides. For carboxyindoles, either decarboxylative coupling or tandem C-H arylation and decarboxylation occurred, leading to the formation of C2-monoarylated indoles.

Original languageEnglish
Pages (from-to)9384-9390
Number of pages7
JournalJournal of Organic Chemistry
Volume77
Issue number20
DOIs
Publication statusPublished - 2012 Oct 19

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All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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