Pd(0)-catalyzed decarboxylative coupling and tandem C-H arylation/decarboxylation for the synthesis of heteroaromatic biaryls

Debkumar Nandi; Yang Ming Jhou; Jhen Yi Lee; Bing Chiuan Kuo; Chien Yu Liu; Pei Wen Huang; Hon Man Lee

doi:10.1021/jo3015837

Pd(0)-catalyzed decarboxylative coupling and tandem C-H arylation/decarboxylation for the synthesis of heteroaromatic biaryls

Debkumar Nandi, Yang Ming Jhou, Jhen Yi Lee, Bing Chiuan Kuo, Chien Yu Liu, Pei Wen Huang, Hon Man Lee

Department of Chemistry

Research output: Contribution to journal › Article

64 Citations (Scopus)

Abstract

An effective Pd(0) carbene complex was successfully employed in the decarboxylative coupling of the heteroaromatic carboxylic acids (imidazo[1,2-a]pyridine and isoxazole) with aryl halides. For carboxyindoles, either decarboxylative coupling or tandem C-H arylation and decarboxylation occurred, leading to the formation of C2-monoarylated indoles.

Original language	English
Pages (from-to)	9384-9390
Number of pages	7
Journal	Journal of Organic Chemistry
Volume	77
Issue number	20
DOIs	https://doi.org/10.1021/jo3015837
Publication status	Published - 2012 Oct 19

All Science Journal Classification (ASJC) codes

Organic Chemistry

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10.1021/jo3015837

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abstract = "An effective Pd(0) carbene complex was successfully employed in the decarboxylative coupling of the heteroaromatic carboxylic acids (imidazo[1,2-a]pyridine and isoxazole) with aryl halides. For carboxyindoles, either decarboxylative coupling or tandem C-H arylation and decarboxylation occurred, leading to the formation of C2-monoarylated indoles.",

author = "Debkumar Nandi and Jhou, {Yang Ming} and Lee, {Jhen Yi} and Kuo, {Bing Chiuan} and Liu, {Chien Yu} and Huang, {Pei Wen} and Lee, {Hon Man}",

year = "2012",

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language = "English",

volume = "77",

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journal = "Journal of Organic Chemistry",

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T1 - Pd(0)-catalyzed decarboxylative coupling and tandem C-H arylation/decarboxylation for the synthesis of heteroaromatic biaryls

AU - Nandi, Debkumar

AU - Jhou, Yang Ming

AU - Lee, Jhen Yi

AU - Kuo, Bing Chiuan

AU - Liu, Chien Yu

AU - Huang, Pei Wen

AU - Lee, Hon Man

PY - 2012/10/19

Y1 - 2012/10/19

N2 - An effective Pd(0) carbene complex was successfully employed in the decarboxylative coupling of the heteroaromatic carboxylic acids (imidazo[1,2-a]pyridine and isoxazole) with aryl halides. For carboxyindoles, either decarboxylative coupling or tandem C-H arylation and decarboxylation occurred, leading to the formation of C2-monoarylated indoles.

AB - An effective Pd(0) carbene complex was successfully employed in the decarboxylative coupling of the heteroaromatic carboxylic acids (imidazo[1,2-a]pyridine and isoxazole) with aryl halides. For carboxyindoles, either decarboxylative coupling or tandem C-H arylation and decarboxylation occurred, leading to the formation of C2-monoarylated indoles.

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JF - Journal of Organic Chemistry

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