Pd(0)-catalyzed decarboxylative coupling and tandem C-H arylation/decarboxylation for the synthesis of heteroaromatic biaryls

Debkumar Nandi; Yang Ming Jhou; Jhen Yi Lee; Bing Chiuan Kuo; Chien Yu Liu; Pei Wen Huang; Hon Man Lee

doi:10.1021/jo3015837

Pd(0)-catalyzed decarboxylative coupling and tandem C-H arylation/decarboxylation for the synthesis of heteroaromatic biaryls

Debkumar Nandi, Yang Ming Jhou, Jhen Yi Lee, Bing Chiuan Kuo, Chien Yu Liu, Pei Wen Huang, Hon Man Lee

Department of Chemistry

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63 Citations (Scopus)

Abstract

An effective Pd(0) carbene complex was successfully employed in the decarboxylative coupling of the heteroaromatic carboxylic acids (imidazo[1,2-a]pyridine and isoxazole) with aryl halides. For carboxyindoles, either decarboxylative coupling or tandem C-H arylation and decarboxylation occurred, leading to the formation of C2-monoarylated indoles.

Original language	English
Pages (from-to)	9384-9390
Number of pages	7
Journal	Journal of Organic Chemistry
Volume	77
Issue number	20
DOIs	https://doi.org/10.1021/jo3015837
Publication status	Published - 2012 Oct 19

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All Science Journal Classification (ASJC) codes

Organic Chemistry

Cite this

Nandi, D., Jhou, Y. M., Lee, J. Y., Kuo, B. C., Liu, C. Y., Huang, P. W., & Lee, H. M. (2012). Pd(0)-catalyzed decarboxylative coupling and tandem C-H arylation/decarboxylation for the synthesis of heteroaromatic biaryls. Journal of Organic Chemistry, 77(20), 9384-9390. https://doi.org/10.1021/jo3015837

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AU - Kuo, Bing Chiuan

AU - Liu, Chien Yu

AU - Huang, Pei Wen

AU - Lee, Hon Man

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10.1021/jo3015837