One-step synthesis of isocoumarins and 3-benzylidenephthalides via ligandless pd-catalyzed oxidative coupling of benzoic acids and vinylarenes

Debkumar Nandi; Debalina Ghosh; Shih Ji Chen; Bing Chiuan Kuo; Nancy M. Wang; Hon Man Lee

doi:10.1021/jo400174w

One-step synthesis of isocoumarins and 3-benzylidenephthalides via ligandless pd-catalyzed oxidative coupling of benzoic acids and vinylarenes

Debkumar Nandi, Debalina Ghosh, Shih Ji Chen, Bing Chiuan Kuo, Nancy M. Wang, Hon Man Lee

Research output: Contribution to journal › Article › peer-review

78 Citations (Scopus)

Abstract

A straightforward synthetic method for the preparation of isocoumarins and 3-benzylidenephthalides via C-H olefination and oxidative coupling of readily available benzoic acids and vinylarenes was developed. The directing effect of the substituents on the benzoic acid allows for the synthesis of both types of lactone in pure form.

Original language	English
Pages (from-to)	3445-3451
Number of pages	7
Journal	Journal of Organic Chemistry
Volume	78
Issue number	7
DOIs	https://doi.org/10.1021/jo400174w
Publication status	Published - 2013 Apr 5

All Science Journal Classification (ASJC) codes

Organic Chemistry

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title = "One-step synthesis of isocoumarins and 3-benzylidenephthalides via ligandless pd-catalyzed oxidative coupling of benzoic acids and vinylarenes",

abstract = "A straightforward synthetic method for the preparation of isocoumarins and 3-benzylidenephthalides via C-H olefination and oxidative coupling of readily available benzoic acids and vinylarenes was developed. The directing effect of the substituents on the benzoic acid allows for the synthesis of both types of lactone in pure form.",

author = "Debkumar Nandi and Debalina Ghosh and Chen, {Shih Ji} and Kuo, {Bing Chiuan} and Wang, {Nancy M.} and Lee, {Hon Man}",

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journal = "Journal of Organic Chemistry",

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One-step synthesis of isocoumarins and 3-benzylidenephthalides via ligandless pd-catalyzed oxidative coupling of benzoic acids and vinylarenes. / Nandi, Debkumar; Ghosh, Debalina; Chen, Shih Ji; Kuo, Bing Chiuan; Wang, Nancy M.; Lee, Hon Man.

In: Journal of Organic Chemistry, Vol. 78, No. 7, 05.04.2013, p. 3445-3451.

Research output: Contribution to journal › Article › peer-review

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AU - Kuo, Bing Chiuan

AU - Wang, Nancy M.

AU - Lee, Hon Man

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