One-step synthesis of isocoumarins and 3-benzylidenephthalides via ligandless pd-catalyzed oxidative coupling of benzoic acids and vinylarenes

Debkumar Nandi, Debalina Ghosh, Shih Ji Chen, Bing Chiuan Kuo, Nancy M. Wang, Hon Man Lee

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69 Citations (Scopus)

Abstract

A straightforward synthetic method for the preparation of isocoumarins and 3-benzylidenephthalides via C-H olefination and oxidative coupling of readily available benzoic acids and vinylarenes was developed. The directing effect of the substituents on the benzoic acid allows for the synthesis of both types of lactone in pure form.

Original languageEnglish
Pages (from-to)3445-3451
Number of pages7
JournalJournal of Organic Chemistry
Volume78
Issue number7
DOIs
Publication statusPublished - 2013 Apr 5

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All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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