Abstract
A straightforward synthetic method for the preparation of isocoumarins and 3-benzylidenephthalides via C-H olefination and oxidative coupling of readily available benzoic acids and vinylarenes was developed. The directing effect of the substituents on the benzoic acid allows for the synthesis of both types of lactone in pure form.
| Original language | English |
|---|---|
| Pages (from-to) | 3445-3451 |
| Number of pages | 7 |
| Journal | Journal of Organic Chemistry |
| Volume | 78 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2013 Apr 5 |
All Science Journal Classification (ASJC) codes
- Organic Chemistry
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Nandi, D., Ghosh, D., Chen, S. J., Kuo, B. C., Wang, N. M., & Lee, H. M. (2013). One-step synthesis of isocoumarins and 3-benzylidenephthalides via ligandless pd-catalyzed oxidative coupling of benzoic acids and vinylarenes. Journal of Organic Chemistry, 78(7), 3445-3451. https://doi.org/10.1021/jo400174w