One-step synthesis of isocoumarins and 3-benzylidenephthalides via ligandless pd-catalyzed oxidative coupling of benzoic acids and vinylarenes

Debkumar Nandi, Debalina Ghosh, Shih Ji Chen, Bing Chiuan Kuo, Nancy M. Wang, Hon Man Lee

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

A straightforward synthetic method for the preparation of isocoumarins and 3-benzylidenephthalides via C-H olefination and oxidative coupling of readily available benzoic acids and vinylarenes was developed. The directing effect of the substituents on the benzoic acid allows for the synthesis of both types of lactone in pure form.

Original languageEnglish
Pages (from-to)3445-3451
Number of pages7
JournalJournal of Organic Chemistry
Volume78
Issue number7
DOIs
Publication statusPublished - 2013 Apr 5

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Benzoic Acid
Benzoates
Lactones
isocoumarin 3
benzylidenephthalide

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

Cite this

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title = "One-step synthesis of isocoumarins and 3-benzylidenephthalides via ligandless pd-catalyzed oxidative coupling of benzoic acids and vinylarenes",
abstract = "A straightforward synthetic method for the preparation of isocoumarins and 3-benzylidenephthalides via C-H olefination and oxidative coupling of readily available benzoic acids and vinylarenes was developed. The directing effect of the substituents on the benzoic acid allows for the synthesis of both types of lactone in pure form.",
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One-step synthesis of isocoumarins and 3-benzylidenephthalides via ligandless pd-catalyzed oxidative coupling of benzoic acids and vinylarenes. / Nandi, Debkumar; Ghosh, Debalina; Chen, Shih Ji; Kuo, Bing Chiuan; Wang, Nancy M.; Lee, Hon Man.

In: Journal of Organic Chemistry, Vol. 78, No. 7, 05.04.2013, p. 3445-3451.

Research output: Contribution to journalArticle

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AU - Chen, Shih Ji

AU - Kuo, Bing Chiuan

AU - Wang, Nancy M.

AU - Lee, Hon Man

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