Obesity/overweight reduces the risk of active tuberculosis

A nationwide population-based cohort study in Taiwan

Y. F. Yen, H. Y. Hu, Y. L. Lee, Po-Wen Ku, I. F. Lin, D. Chu, Y. J. Lai

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background:Obesity affects immune function by increasing the number of T helper lymphocytes, which may reduce the risk of tuberculosis (TB) infection. However, the effect of obesity on TB development has not been extensively studied. This nationwide population-based cohort study investigated the effect of obesity on TB development in Taiwanese adults.Methods:We included 46 028 adult participants (age 3/418 years) from three rounds (2001, 2005 and 2009) of the Taiwan National Health Interview Survey. Obesity and overweight were defined as a body mass index (BMI) 3/427 and 24-26.9 (kg/m 2), respectively. Data on BMI and other covariates at baseline were collected by in-person interviews. Incident cases of active TB were identified from the National Health Insurance database. Multivariable logistic regression was used to estimate the associations of obesity and overweight with active TB, with adjustment for age, sex, smoking, alcohol consumption, socioeconomic status and other covariates.Results:In total, 241 new cases of active TB occurred during the study period. Obesity (adjusted odds ratio [AOR], 0.43; 95% confident interval [CI], 0.28-0.67) and overweight (AOR, 0.67; 95% CI, 0.49-0.91) were associated with lower risk of incident TB, after adjusting for demographic characteristics and comorbidities. There was a linear dose-response relation of BMI with active TB incidence (AOR per unit change in BMI, 0.92; 95% CI, 0.88-0.95; P <0.001).Conclusion:Obesity and overweight are associated with lower risk of active TB. Future studies should investigate the underlying mechanisms and clinical and epidemiological consequences of these findings.

Original languageEnglish
Pages (from-to)971-975
Number of pages5
JournalInternational Journal of Obesity
Volume41
Issue number6
DOIs
Publication statusPublished - 2017 Jun 1

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Taiwan
Tuberculosis
Cohort Studies
Obesity
Population
Body Mass Index
Odds Ratio
Interviews
National Health Programs
Helper-Inducer T-Lymphocytes
Health Surveys
Social Class
Alcohol Drinking
Comorbidity
Logistic Models
Smoking
Demography
Databases
Incidence
Infection

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Yen, Y. F. ; Hu, H. Y. ; Lee, Y. L. ; Ku, Po-Wen ; Lin, I. F. ; Chu, D. ; Lai, Y. J. / Obesity/overweight reduces the risk of active tuberculosis : A nationwide population-based cohort study in Taiwan. In: International Journal of Obesity. 2017 ; Vol. 41, No. 6. pp. 971-975.
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abstract = "Background:Obesity affects immune function by increasing the number of T helper lymphocytes, which may reduce the risk of tuberculosis (TB) infection. However, the effect of obesity on TB development has not been extensively studied. This nationwide population-based cohort study investigated the effect of obesity on TB development in Taiwanese adults.Methods:We included 46 028 adult participants (age 3/418 years) from three rounds (2001, 2005 and 2009) of the Taiwan National Health Interview Survey. Obesity and overweight were defined as a body mass index (BMI) 3/427 and 24-26.9 (kg/m 2), respectively. Data on BMI and other covariates at baseline were collected by in-person interviews. Incident cases of active TB were identified from the National Health Insurance database. Multivariable logistic regression was used to estimate the associations of obesity and overweight with active TB, with adjustment for age, sex, smoking, alcohol consumption, socioeconomic status and other covariates.Results:In total, 241 new cases of active TB occurred during the study period. Obesity (adjusted odds ratio [AOR], 0.43; 95{\%} confident interval [CI], 0.28-0.67) and overweight (AOR, 0.67; 95{\%} CI, 0.49-0.91) were associated with lower risk of incident TB, after adjusting for demographic characteristics and comorbidities. There was a linear dose-response relation of BMI with active TB incidence (AOR per unit change in BMI, 0.92; 95{\%} CI, 0.88-0.95; P <0.001).Conclusion:Obesity and overweight are associated with lower risk of active TB. Future studies should investigate the underlying mechanisms and clinical and epidemiological consequences of these findings.",
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Obesity/overweight reduces the risk of active tuberculosis : A nationwide population-based cohort study in Taiwan. / Yen, Y. F.; Hu, H. Y.; Lee, Y. L.; Ku, Po-Wen; Lin, I. F.; Chu, D.; Lai, Y. J.

In: International Journal of Obesity, Vol. 41, No. 6, 01.06.2017, p. 971-975.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Obesity/overweight reduces the risk of active tuberculosis

T2 - A nationwide population-based cohort study in Taiwan

AU - Yen, Y. F.

AU - Hu, H. Y.

AU - Lee, Y. L.

AU - Ku, Po-Wen

AU - Lin, I. F.

AU - Chu, D.

AU - Lai, Y. J.

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Background:Obesity affects immune function by increasing the number of T helper lymphocytes, which may reduce the risk of tuberculosis (TB) infection. However, the effect of obesity on TB development has not been extensively studied. This nationwide population-based cohort study investigated the effect of obesity on TB development in Taiwanese adults.Methods:We included 46 028 adult participants (age 3/418 years) from three rounds (2001, 2005 and 2009) of the Taiwan National Health Interview Survey. Obesity and overweight were defined as a body mass index (BMI) 3/427 and 24-26.9 (kg/m 2), respectively. Data on BMI and other covariates at baseline were collected by in-person interviews. Incident cases of active TB were identified from the National Health Insurance database. Multivariable logistic regression was used to estimate the associations of obesity and overweight with active TB, with adjustment for age, sex, smoking, alcohol consumption, socioeconomic status and other covariates.Results:In total, 241 new cases of active TB occurred during the study period. Obesity (adjusted odds ratio [AOR], 0.43; 95% confident interval [CI], 0.28-0.67) and overweight (AOR, 0.67; 95% CI, 0.49-0.91) were associated with lower risk of incident TB, after adjusting for demographic characteristics and comorbidities. There was a linear dose-response relation of BMI with active TB incidence (AOR per unit change in BMI, 0.92; 95% CI, 0.88-0.95; P <0.001).Conclusion:Obesity and overweight are associated with lower risk of active TB. Future studies should investigate the underlying mechanisms and clinical and epidemiological consequences of these findings.

AB - Background:Obesity affects immune function by increasing the number of T helper lymphocytes, which may reduce the risk of tuberculosis (TB) infection. However, the effect of obesity on TB development has not been extensively studied. This nationwide population-based cohort study investigated the effect of obesity on TB development in Taiwanese adults.Methods:We included 46 028 adult participants (age 3/418 years) from three rounds (2001, 2005 and 2009) of the Taiwan National Health Interview Survey. Obesity and overweight were defined as a body mass index (BMI) 3/427 and 24-26.9 (kg/m 2), respectively. Data on BMI and other covariates at baseline were collected by in-person interviews. Incident cases of active TB were identified from the National Health Insurance database. Multivariable logistic regression was used to estimate the associations of obesity and overweight with active TB, with adjustment for age, sex, smoking, alcohol consumption, socioeconomic status and other covariates.Results:In total, 241 new cases of active TB occurred during the study period. Obesity (adjusted odds ratio [AOR], 0.43; 95% confident interval [CI], 0.28-0.67) and overweight (AOR, 0.67; 95% CI, 0.49-0.91) were associated with lower risk of incident TB, after adjusting for demographic characteristics and comorbidities. There was a linear dose-response relation of BMI with active TB incidence (AOR per unit change in BMI, 0.92; 95% CI, 0.88-0.95; P <0.001).Conclusion:Obesity and overweight are associated with lower risk of active TB. Future studies should investigate the underlying mechanisms and clinical and epidemiological consequences of these findings.

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