No evidence of correlation between mutation at codon 531 of src and the risk of colon cancer in Chinese

Nancy M. Wang, Kun Tu Yeh, Chan Hai Tsai, Shu Jung Chen, Jan Gowth Chang

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35 Citations (Scopus)

Abstract

The protein tyrosine kinase activity of c-src proto-oncogene product, pp60(c-src), is elevated in a number of human cancers, including colon cancer. Phosphorylation of human pp60(c-src) carboxy-terminal tyrosine 530 suppresses its kinase activity. A recent report suggested that the risk of colon cancer is higher for those who carry a C → T transition mutation on codon 531 (Gln-531 → Amber-531) of src gene. This mutation caused a prematured translation termination and up-regulated the kinase activity. To examine whether this mutation could be a risk factor for colon carcinoma in the Chinese population, we used the same PCR-based assay to analyze src genotypes of 131 colon cancers and other various types of carcinoma. No mutation was detected in all specimens that were screened in this study. Thus, mutation at Gln-531 of src gene does not seem to be involved in the development of colon cancer in Chinese ethnicity. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)201-204
Number of pages4
JournalCancer Letters
Volume150
Issue number2
DOIs
Publication statusPublished - 2000 Mar 31

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All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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