Mutational screening of breast cancer susceptibility gene 1 from early onset, bi-lateral, and familial breast cancer patients in Taiwan

Shou Tung Chen, Ruei A. Chen, Shou Jen Kuo, Yi-Chih Chien

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The BRCA1 gene has been shown to be strongly associated with the occurrence of familial breast cancer. The spectrum of BRCA1 gene mutations in breast cancer patients in various populations has been investigated. In this study, patients in Central Taiwan with breast cancer were screened for BRCA1 mutations by sequencing PCR products spanning the coding region and partial intronic regions of the BRCA1 gene. Twelve polymorphisms in four exons and three introns were found. One mutation was found in one patient with familial breast cancer. Two patients showed LOH at the locus of BRCA1. Also found in the Taiwanese population were two common haplotypes and one rare haplotype of BRCA1. These results suggest that the mutation of BRCA1 contributes little to the occurrence of breast cancer in the Taiwanese population.

Original languageEnglish
Pages (from-to)133-143
Number of pages11
JournalBreast Cancer Research and Treatment
Volume77
Issue number2
DOIs
Publication statusPublished - 2003 Jan 1

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Neoplasm Genes
BRCA1 Gene
Taiwan
Breast Neoplasms
Mutation
Haplotypes
Population
Introns
Exons
Polymerase Chain Reaction
Familial Breast Cancer

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

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title = "Mutational screening of breast cancer susceptibility gene 1 from early onset, bi-lateral, and familial breast cancer patients in Taiwan",
abstract = "The BRCA1 gene has been shown to be strongly associated with the occurrence of familial breast cancer. The spectrum of BRCA1 gene mutations in breast cancer patients in various populations has been investigated. In this study, patients in Central Taiwan with breast cancer were screened for BRCA1 mutations by sequencing PCR products spanning the coding region and partial intronic regions of the BRCA1 gene. Twelve polymorphisms in four exons and three introns were found. One mutation was found in one patient with familial breast cancer. Two patients showed LOH at the locus of BRCA1. Also found in the Taiwanese population were two common haplotypes and one rare haplotype of BRCA1. These results suggest that the mutation of BRCA1 contributes little to the occurrence of breast cancer in the Taiwanese population.",
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Mutational screening of breast cancer susceptibility gene 1 from early onset, bi-lateral, and familial breast cancer patients in Taiwan. / Chen, Shou Tung; Chen, Ruei A.; Kuo, Shou Jen; Chien, Yi-Chih.

In: Breast Cancer Research and Treatment, Vol. 77, No. 2, 01.01.2003, p. 133-143.

Research output: Contribution to journalArticle

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