Mutation analysis of the Bcl 10 gene in hepatocellular carcinoma.

K. T. Yeh, N. M. Wang, H. H. Lee, J. G. Chang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The Bcl 10 gene was recently discovered to be involved in the pathogenesis of lymphoma of mucosa-associated lymphoid tissue and several types of tumorous cell lines. We examined the mutation of Bcl 10 gene in 31 hepatocellular carcinomas along with their corresponding non-tumorous tissues by single strand conformation polymorphism (SSCP) and direct sequencing. The results showed that 11.3% chromosomes had codon 5 GCA to TCA mutation, 4.8% chromosomes had codon 8 CTC to CTG mutation, and 12.9% chromosomes had codon 213 GGA to GAA mutation. These mutations were found not only in the hepatoma tissues but also in paired non-cancerous tissues and the normal population. We suggest that these three changes are polymorphisms, and there is no relationship with the development of hepatocellular carcinoma.

Original languageEnglish
Pages (from-to)332-338
Number of pages7
JournalThe Kaohsiung journal of medical sciences
Volume16
Issue number7
Publication statusPublished - 2000 Jul

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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