Mutation analysis of the Bcl 10 gene in hepatocellular carcinoma.

K. T. Yeh, Miau-Yaun Wang, H. H. Lee, J. G. Chang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The Bcl 10 gene was recently discovered to be involved in the pathogenesis of lymphoma of mucosa-associated lymphoid tissue and several types of tumorous cell lines. We examined the mutation of Bcl 10 gene in 31 hepatocellular carcinomas along with their corresponding non-tumorous tissues by single strand conformation polymorphism (SSCP) and direct sequencing. The results showed that 11.3% chromosomes had codon 5 GCA to TCA mutation, 4.8% chromosomes had codon 8 CTC to CTG mutation, and 12.9% chromosomes had codon 213 GGA to GAA mutation. These mutations were found not only in the hepatoma tissues but also in paired non-cancerous tissues and the normal population. We suggest that these three changes are polymorphisms, and there is no relationship with the development of hepatocellular carcinoma.

Original languageEnglish
Pages (from-to)332-338
Number of pages7
JournalThe Kaohsiung journal of medical sciences
Volume16
Issue number7
Publication statusPublished - 2000 Jan 1

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Hepatocellular Carcinoma
Mutation
Codon
Chromosomes
Genes
Marginal Zone B-Cell Lymphoma
Cell Line
Population

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Yeh, K. T. ; Wang, Miau-Yaun ; Lee, H. H. ; Chang, J. G. / Mutation analysis of the Bcl 10 gene in hepatocellular carcinoma. In: The Kaohsiung journal of medical sciences. 2000 ; Vol. 16, No. 7. pp. 332-338.
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Mutation analysis of the Bcl 10 gene in hepatocellular carcinoma. / Yeh, K. T.; Wang, Miau-Yaun; Lee, H. H.; Chang, J. G.

In: The Kaohsiung journal of medical sciences, Vol. 16, No. 7, 01.01.2000, p. 332-338.

Research output: Contribution to journalArticle

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