Abstract
The Bcl 10 gene was recently discovered to be involved in the pathogenesis of lymphoma of mucosa-associated lymphoid tissue and several types of tumorous cell lines. We examined the mutation of Bcl 10 gene in 31 hepatocellular carcinomas along with their corresponding non-tumorous tissues by single strand conformation polymorphism (SSCP) and direct sequencing. The results showed that 11.3% chromosomes had codon 5 GCA to TCA mutation, 4.8% chromosomes had codon 8 CTC to CTG mutation, and 12.9% chromosomes had codon 213 GGA to GAA mutation. These mutations were found not only in the hepatoma tissues but also in paired non-cancerous tissues and the normal population. We suggest that these three changes are polymorphisms, and there is no relationship with the development of hepatocellular carcinoma.
| Original language | English |
|---|---|
| Pages (from-to) | 332-338 |
| Number of pages | 7 |
| Journal | The Kaohsiung journal of medical sciences |
| Volume | 16 |
| Issue number | 7 |
| Publication status | Published - 2000 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
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Mutation analysis of the Bcl 10 gene in hepatocellular carcinoma. / Yeh, K. T.; Wang, Miau-Yaun; Lee, H. H.; Chang, J. G.
In: The Kaohsiung journal of medical sciences, Vol. 16, No. 7, 01.01.2000, p. 332-338.Research output: Contribution to journal › Article
TY - JOUR
T1 - Mutation analysis of the Bcl 10 gene in hepatocellular carcinoma.
AU - Yeh, K. T.
AU - Wang, Miau-Yaun
AU - Lee, H. H.
AU - Chang, J. G.
PY - 2000/1/1
Y1 - 2000/1/1
N2 - The Bcl 10 gene was recently discovered to be involved in the pathogenesis of lymphoma of mucosa-associated lymphoid tissue and several types of tumorous cell lines. We examined the mutation of Bcl 10 gene in 31 hepatocellular carcinomas along with their corresponding non-tumorous tissues by single strand conformation polymorphism (SSCP) and direct sequencing. The results showed that 11.3% chromosomes had codon 5 GCA to TCA mutation, 4.8% chromosomes had codon 8 CTC to CTG mutation, and 12.9% chromosomes had codon 213 GGA to GAA mutation. These mutations were found not only in the hepatoma tissues but also in paired non-cancerous tissues and the normal population. We suggest that these three changes are polymorphisms, and there is no relationship with the development of hepatocellular carcinoma.
AB - The Bcl 10 gene was recently discovered to be involved in the pathogenesis of lymphoma of mucosa-associated lymphoid tissue and several types of tumorous cell lines. We examined the mutation of Bcl 10 gene in 31 hepatocellular carcinomas along with their corresponding non-tumorous tissues by single strand conformation polymorphism (SSCP) and direct sequencing. The results showed that 11.3% chromosomes had codon 5 GCA to TCA mutation, 4.8% chromosomes had codon 8 CTC to CTG mutation, and 12.9% chromosomes had codon 213 GGA to GAA mutation. These mutations were found not only in the hepatoma tissues but also in paired non-cancerous tissues and the normal population. We suggest that these three changes are polymorphisms, and there is no relationship with the development of hepatocellular carcinoma.
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UR - http://www.scopus.com/inward/citedby.url?scp=0034218248&partnerID=8YFLogxK
M3 - Article
VL - 16
SP - 332
EP - 338
JO - Kaohsiung Journal of Medical Sciences
JF - Kaohsiung Journal of Medical Sciences
SN - 1607-551X
IS - 7
ER -