Abstract
Here, we present a series of novel paeonol derivatives that prevent lipid accumulation at lower doses and exhibit improved water solubility. According to SAR analysis results, 1-(4-methoxy-2-(2-(piperidin-1-yl)ethoxy)phenyl)ethanone (6a) and 4′-methoxy-2′-[(phenylsulfonyl)oxy]acetophenone (7a) demonstrate as good inhibition ability at low-dose (10 μg mL-1) as that of paeonol at high-dose (100 μg mL-1). In addition, compounds 6a and 7a can be synthesized quantitatively with simple preparation methods. Hence, we believe that compounds 6a and 7a are potentially suitable antiatherogenic compounds for future drug development. This journal is
| Original language | English |
|---|---|
| Pages (from-to) | 5652-5656 |
| Number of pages | 5 |
| Journal | RSC Advances |
| Volume | 5 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2015 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Chemistry(all)
- Chemical Engineering(all)
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Low-dose paeonol derivatives alleviate lipid accumulation. / Pao, Kuan Chuan; Zhao, Jin Feng; Lee, Tzong Shyuan; Huang, Ying Pei; Han, Chien Chung; Sherlock Huang, Lin Chiang; Wu, Kou Hung; Hsu, Ming Hua.
In: RSC Advances, Vol. 5, No. 8, 01.01.2015, p. 5652-5656.Research output: Contribution to journal › Article
TY - JOUR
T1 - Low-dose paeonol derivatives alleviate lipid accumulation
AU - Pao, Kuan Chuan
AU - Zhao, Jin Feng
AU - Lee, Tzong Shyuan
AU - Huang, Ying Pei
AU - Han, Chien Chung
AU - Sherlock Huang, Lin Chiang
AU - Wu, Kou Hung
AU - Hsu, Ming Hua
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Here, we present a series of novel paeonol derivatives that prevent lipid accumulation at lower doses and exhibit improved water solubility. According to SAR analysis results, 1-(4-methoxy-2-(2-(piperidin-1-yl)ethoxy)phenyl)ethanone (6a) and 4′-methoxy-2′-[(phenylsulfonyl)oxy]acetophenone (7a) demonstrate as good inhibition ability at low-dose (10 μg mL-1) as that of paeonol at high-dose (100 μg mL-1). In addition, compounds 6a and 7a can be synthesized quantitatively with simple preparation methods. Hence, we believe that compounds 6a and 7a are potentially suitable antiatherogenic compounds for future drug development. This journal is
AB - Here, we present a series of novel paeonol derivatives that prevent lipid accumulation at lower doses and exhibit improved water solubility. According to SAR analysis results, 1-(4-methoxy-2-(2-(piperidin-1-yl)ethoxy)phenyl)ethanone (6a) and 4′-methoxy-2′-[(phenylsulfonyl)oxy]acetophenone (7a) demonstrate as good inhibition ability at low-dose (10 μg mL-1) as that of paeonol at high-dose (100 μg mL-1). In addition, compounds 6a and 7a can be synthesized quantitatively with simple preparation methods. Hence, we believe that compounds 6a and 7a are potentially suitable antiatherogenic compounds for future drug development. This journal is
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UR - http://www.scopus.com/inward/citedby.url?scp=84921925309&partnerID=8YFLogxK
U2 - 10.1039/c4ra13986k
DO - 10.1039/c4ra13986k
M3 - Article
VL - 5
SP - 5652
EP - 5656
JO - RSC Advances
JF - RSC Advances
SN - 2046-2069
IS - 8
ER -