Low-dose paeonol derivatives alleviate lipid accumulation

Kuan Chuan Pao, Jin Feng Zhao, Tzong Shyuan Lee, Ying Pei Huang, Chien Chung Han, Lin Chiang Sherlock Huang, Kou Hung Wu, Ming Hua Hsu

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Here, we present a series of novel paeonol derivatives that prevent lipid accumulation at lower doses and exhibit improved water solubility. According to SAR analysis results, 1-(4-methoxy-2-(2-(piperidin-1-yl)ethoxy)phenyl)ethanone (6a) and 4′-methoxy-2′-[(phenylsulfonyl)oxy]acetophenone (7a) demonstrate as good inhibition ability at low-dose (10 μg mL-1) as that of paeonol at high-dose (100 μg mL-1). In addition, compounds 6a and 7a can be synthesized quantitatively with simple preparation methods. Hence, we believe that compounds 6a and 7a are potentially suitable antiatherogenic compounds for future drug development. This journal is

Original languageEnglish
Pages (from-to)5652-5656
Number of pages5
JournalRSC Advances
Volume5
Issue number8
DOIs
Publication statusPublished - 2015

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Pao, K. C., Zhao, J. F., Lee, T. S., Huang, Y. P., Han, C. C., Sherlock Huang, L. C., Wu, K. H., & Hsu, M. H. (2015). Low-dose paeonol derivatives alleviate lipid accumulation. RSC Advances, 5(8), 5652-5656. https://doi.org/10.1039/c4ra13986k