Low-dose paeonol derivatives alleviate lipid accumulation

Kuan Chuan Pao, Jin Feng Zhao, Tzong Shyuan Lee, Ying Pei Huang, Chien Chung Han, Lin Chiang Sherlock Huang, Kou Hung Wu, Ming Hua Hsu

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Here, we present a series of novel paeonol derivatives that prevent lipid accumulation at lower doses and exhibit improved water solubility. According to SAR analysis results, 1-(4-methoxy-2-(2-(piperidin-1-yl)ethoxy)phenyl)ethanone (6a) and 4′-methoxy-2′-[(phenylsulfonyl)oxy]acetophenone (7a) demonstrate as good inhibition ability at low-dose (10 μg mL-1) as that of paeonol at high-dose (100 μg mL-1). In addition, compounds 6a and 7a can be synthesized quantitatively with simple preparation methods. Hence, we believe that compounds 6a and 7a are potentially suitable antiatherogenic compounds for future drug development. This journal is

Original languageEnglish
Pages (from-to)5652-5656
Number of pages5
JournalRSC Advances
Volume5
Issue number8
DOIs
Publication statusPublished - 2015 Jan 1

Fingerprint

Lipids
Solubility
Derivatives
Water
Pharmaceutical Preparations
paeonol
acetophenone

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Pao, K. C., Zhao, J. F., Lee, T. S., Huang, Y. P., Han, C. C., Sherlock Huang, L. C., ... Hsu, M. H. (2015). Low-dose paeonol derivatives alleviate lipid accumulation. RSC Advances, 5(8), 5652-5656. https://doi.org/10.1039/c4ra13986k
Pao, Kuan Chuan ; Zhao, Jin Feng ; Lee, Tzong Shyuan ; Huang, Ying Pei ; Han, Chien Chung ; Sherlock Huang, Lin Chiang ; Wu, Kou Hung ; Hsu, Ming Hua. / Low-dose paeonol derivatives alleviate lipid accumulation. In: RSC Advances. 2015 ; Vol. 5, No. 8. pp. 5652-5656.
@article{bc811054f85242938535ba197ea5c5d8,
title = "Low-dose paeonol derivatives alleviate lipid accumulation",
abstract = "Here, we present a series of novel paeonol derivatives that prevent lipid accumulation at lower doses and exhibit improved water solubility. According to SAR analysis results, 1-(4-methoxy-2-(2-(piperidin-1-yl)ethoxy)phenyl)ethanone (6a) and 4′-methoxy-2′-[(phenylsulfonyl)oxy]acetophenone (7a) demonstrate as good inhibition ability at low-dose (10 μg mL-1) as that of paeonol at high-dose (100 μg mL-1). In addition, compounds 6a and 7a can be synthesized quantitatively with simple preparation methods. Hence, we believe that compounds 6a and 7a are potentially suitable antiatherogenic compounds for future drug development. This journal is",
author = "Pao, {Kuan Chuan} and Zhao, {Jin Feng} and Lee, {Tzong Shyuan} and Huang, {Ying Pei} and Han, {Chien Chung} and {Sherlock Huang}, {Lin Chiang} and Wu, {Kou Hung} and Hsu, {Ming Hua}",
year = "2015",
month = "1",
day = "1",
doi = "10.1039/c4ra13986k",
language = "English",
volume = "5",
pages = "5652--5656",
journal = "RSC Advances",
issn = "2046-2069",
publisher = "Royal Society of Chemistry",
number = "8",

}

Pao, KC, Zhao, JF, Lee, TS, Huang, YP, Han, CC, Sherlock Huang, LC, Wu, KH & Hsu, MH 2015, 'Low-dose paeonol derivatives alleviate lipid accumulation', RSC Advances, vol. 5, no. 8, pp. 5652-5656. https://doi.org/10.1039/c4ra13986k

Low-dose paeonol derivatives alleviate lipid accumulation. / Pao, Kuan Chuan; Zhao, Jin Feng; Lee, Tzong Shyuan; Huang, Ying Pei; Han, Chien Chung; Sherlock Huang, Lin Chiang; Wu, Kou Hung; Hsu, Ming Hua.

In: RSC Advances, Vol. 5, No. 8, 01.01.2015, p. 5652-5656.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Low-dose paeonol derivatives alleviate lipid accumulation

AU - Pao, Kuan Chuan

AU - Zhao, Jin Feng

AU - Lee, Tzong Shyuan

AU - Huang, Ying Pei

AU - Han, Chien Chung

AU - Sherlock Huang, Lin Chiang

AU - Wu, Kou Hung

AU - Hsu, Ming Hua

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Here, we present a series of novel paeonol derivatives that prevent lipid accumulation at lower doses and exhibit improved water solubility. According to SAR analysis results, 1-(4-methoxy-2-(2-(piperidin-1-yl)ethoxy)phenyl)ethanone (6a) and 4′-methoxy-2′-[(phenylsulfonyl)oxy]acetophenone (7a) demonstrate as good inhibition ability at low-dose (10 μg mL-1) as that of paeonol at high-dose (100 μg mL-1). In addition, compounds 6a and 7a can be synthesized quantitatively with simple preparation methods. Hence, we believe that compounds 6a and 7a are potentially suitable antiatherogenic compounds for future drug development. This journal is

AB - Here, we present a series of novel paeonol derivatives that prevent lipid accumulation at lower doses and exhibit improved water solubility. According to SAR analysis results, 1-(4-methoxy-2-(2-(piperidin-1-yl)ethoxy)phenyl)ethanone (6a) and 4′-methoxy-2′-[(phenylsulfonyl)oxy]acetophenone (7a) demonstrate as good inhibition ability at low-dose (10 μg mL-1) as that of paeonol at high-dose (100 μg mL-1). In addition, compounds 6a and 7a can be synthesized quantitatively with simple preparation methods. Hence, we believe that compounds 6a and 7a are potentially suitable antiatherogenic compounds for future drug development. This journal is

UR - http://www.scopus.com/inward/record.url?scp=84921925309&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84921925309&partnerID=8YFLogxK

U2 - 10.1039/c4ra13986k

DO - 10.1039/c4ra13986k

M3 - Article

VL - 5

SP - 5652

EP - 5656

JO - RSC Advances

JF - RSC Advances

SN - 2046-2069

IS - 8

ER -

Pao KC, Zhao JF, Lee TS, Huang YP, Han CC, Sherlock Huang LC et al. Low-dose paeonol derivatives alleviate lipid accumulation. RSC Advances. 2015 Jan 1;5(8):5652-5656. https://doi.org/10.1039/c4ra13986k