Low-dose paeonol derivatives alleviate lipid accumulation

Here, we present a series of novel paeonol derivatives that prevent lipid accumulation at lower doses and exhibit improved water solubility. According to SAR analysis results, 1-(4-methoxy-2-(2-(piperidin-1-yl)ethoxy)phenyl)ethanone (6a) and 4′-methoxy-2′-[(phenylsulfonyl)oxy]acetophenone (7a) demonstrate as good inhibition ability at low-dose (10 μg mL^-1) as that of paeonol at high-dose (100 μg mL^-1). In addition, compounds 6a and 7a can be synthesized quantitatively with simple preparation methods. Hence, we believe that compounds 6a and 7a are potentially suitable antiatherogenic compounds for future drug development. This journal is