Abstract
(matrix presented) Yttrium-salen complexes effect transacylation between enolesters and chiral secondary alcohols, resulting in varying degrees of kinetic resolution. Even though the enantioselectivity remains modest (kfast/kslow up to 4.81), these results represent the first demonstration of a conceptually new metal-catalyzed acyl transfer process that results in kinetic resolution. On the basis of the solid-state structure of the catalyst, a novel associative mechanistic pathway is proposed for the reaction.
Original language | English |
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Pages (from-to) | 1607-1610 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 4 |
Issue number | 9 |
DOIs | |
Publication status | Published - 2002 May 2 |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry