Abstract
Replicative capacity, which is the number of times an individual cell divides, is the measure of longevity in the yeast Saccharomyces cerevisiae. In this study, a process that involves signaling from the mitochondrion to the nucleus, called retrograde regulation, is shown to determine yeast longevity, and its induction resulted in postponed senescence. Activation of retrograde regulation, by genetic and environmental means, correlated with increased replicative capacity in four different S. cerevisiae strains. Deletion of a gene required for the retrograde response, RTG2, eliminated the increased replicative capacity. RAS2, a gene previously shown to influence longevity in yeast, interacts with retrograde regulation in setting yeast longevity. The molecular mechanism of aging elucidated here parallels the results of genetic studies of aging in nematodes and fruit flies, as well as the caloric restriction paradigm in mammals, and it underscores the importance of metabolic regulation in aging, suggesting a general applicability.
| Original language | English |
|---|---|
| Pages (from-to) | 179-190 |
| Number of pages | 12 |
| Journal | Genetics |
| Volume | 152 |
| Issue number | 1 |
| Publication status | Published - 1999 May 1 |
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All Science Journal Classification (ASJC) codes
- Genetics
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Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae. / Kirchman, Paul A.; Kim, Sangkyu; Lai, Chi-Yung; Michal Jazwinski, S.
In: Genetics, Vol. 152, No. 1, 01.05.1999, p. 179-190.Research output: Contribution to journal › Article
TY - JOUR
T1 - Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae
AU - Kirchman, Paul A.
AU - Kim, Sangkyu
AU - Lai, Chi-Yung
AU - Michal Jazwinski, S.
PY - 1999/5/1
Y1 - 1999/5/1
N2 - Replicative capacity, which is the number of times an individual cell divides, is the measure of longevity in the yeast Saccharomyces cerevisiae. In this study, a process that involves signaling from the mitochondrion to the nucleus, called retrograde regulation, is shown to determine yeast longevity, and its induction resulted in postponed senescence. Activation of retrograde regulation, by genetic and environmental means, correlated with increased replicative capacity in four different S. cerevisiae strains. Deletion of a gene required for the retrograde response, RTG2, eliminated the increased replicative capacity. RAS2, a gene previously shown to influence longevity in yeast, interacts with retrograde regulation in setting yeast longevity. The molecular mechanism of aging elucidated here parallels the results of genetic studies of aging in nematodes and fruit flies, as well as the caloric restriction paradigm in mammals, and it underscores the importance of metabolic regulation in aging, suggesting a general applicability.
AB - Replicative capacity, which is the number of times an individual cell divides, is the measure of longevity in the yeast Saccharomyces cerevisiae. In this study, a process that involves signaling from the mitochondrion to the nucleus, called retrograde regulation, is shown to determine yeast longevity, and its induction resulted in postponed senescence. Activation of retrograde regulation, by genetic and environmental means, correlated with increased replicative capacity in four different S. cerevisiae strains. Deletion of a gene required for the retrograde response, RTG2, eliminated the increased replicative capacity. RAS2, a gene previously shown to influence longevity in yeast, interacts with retrograde regulation in setting yeast longevity. The molecular mechanism of aging elucidated here parallels the results of genetic studies of aging in nematodes and fruit flies, as well as the caloric restriction paradigm in mammals, and it underscores the importance of metabolic regulation in aging, suggesting a general applicability.
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M3 - Article
VL - 152
SP - 179
EP - 190
JO - Genetics
JF - Genetics
SN - 0016-6731
IS - 1
ER -