Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae

Paul A. Kirchman, Sangkyu Kim, Chi Yung Lai, S. Michal Jazwinski

Research output: Contribution to journalArticle

253 Citations (Scopus)

Abstract

Replicative capacity, which is the number of times an individual cell divides, is the measure of longevity in the yeast Saccharomyces cerevisiae. In this study, a process that involves signaling from the mitochondrion to the nucleus, called retrograde regulation, is shown to determine yeast longevity, and its induction resulted in postponed senescence. Activation of retrograde regulation, by genetic and environmental means, correlated with increased replicative capacity in four different S. cerevisiae strains. Deletion of a gene required for the retrograde response, RTG2, eliminated the increased replicative capacity. RAS2, a gene previously shown to influence longevity in yeast, interacts with retrograde regulation in setting yeast longevity. The molecular mechanism of aging elucidated here parallels the results of genetic studies of aging in nematodes and fruit flies, as well as the caloric restriction paradigm in mammals, and it underscores the importance of metabolic regulation in aging, suggesting a general applicability.

Original languageEnglish
Pages (from-to)179-190
Number of pages12
JournalGenetics
Volume152
Issue number1
Publication statusPublished - 1999 May 1

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Saccharomyces cerevisiae
Yeasts
Caloric Restriction
Gene Deletion
Diptera
Mammals
Fruit
Mitochondria
Genes

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Kirchman, P. A., Kim, S., Lai, C. Y., & Michal Jazwinski, S. (1999). Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae. Genetics, 152(1), 179-190.
Kirchman, Paul A. ; Kim, Sangkyu ; Lai, Chi Yung ; Michal Jazwinski, S. / Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae. In: Genetics. 1999 ; Vol. 152, No. 1. pp. 179-190.
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Kirchman, PA, Kim, S, Lai, CY & Michal Jazwinski, S 1999, 'Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae', Genetics, vol. 152, no. 1, pp. 179-190.

Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae. / Kirchman, Paul A.; Kim, Sangkyu; Lai, Chi Yung; Michal Jazwinski, S.

In: Genetics, Vol. 152, No. 1, 01.05.1999, p. 179-190.

Research output: Contribution to journalArticle

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Kirchman PA, Kim S, Lai CY, Michal Jazwinski S. Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae. Genetics. 1999 May 1;152(1):179-190.