Recent developments in social network analysis (SNA) and data mining (DM) technology have opened up new frontiers for human resource management (HRM). SNA appears to be an effective tool for mapping relationships in an organization. The increased use of information technology provides useful new data about the user behavior automatically stored in database or web log files. Data mining methods were applied in practice to explore information from this huge amount of data. Data mining can be used to gain insight into the usage behavior based on objective data in contrast to subjective data. In this chapter we suggest ways in which combine SNA and DM be analyzed using network software and DM tool. We propose an example used exploratory research design conducting a single case study in Taiwan. This research aims at introducing the importance of the application of DM and SNA to predict layoff through an empirical study.