Influenza vaccination and the endurance against air pollution among elderly with acute coronary syndrome

Ching Hui Huang, Day Yu Chao, Chao Chun Wu, Shu Yun Hsu, Maw Soan Soon, Chia Chu Chang, Chew Teng Kor, Wan Tzu Chang, Iebin Lian

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective Air pollution, weather condition and influenza are known risk factors of acute coronary syndrome (ACS) among elderly people. The influenza vaccine (IV) has been shown to reduce major cardiovascular events. The purpose of this study was to compare resistance to air pollution and weather factors causing ACS between vaccinated and less-vaccinated elderly people. Methods A case–crossover design was applied to 1835 elderly ACS patients who were obtained from the 1-million sample of Taiwan National Health Insurance Research Data with inclusion criteria: (1) the first diagnosis of ACS was in cold season and at age 68 or more, (2) had received the free IV program at least once during the period 3 years before the ACS. They were stratified into two groups: 707 had received flu vaccinations for all the 3 years and the remaining 1128 had not. The measurements of air pollutants, temperature, and humidity corresponding to each of the 3 days prior to the ACS diagnosis date were retrieved from the data banks of the Taiwan Environmental Protection Administration and Central Weather Bureau. Findings Increases in air pollution concentrations of CO, NO2, PM10 or PM2.5 and decreases in temperature significantly influenced the risk of ACS for the non-continuously vaccinated elderly population; however, less significant effects were observed for the continuously vaccinated population. Conclusion Consecutive influenza vaccination may potentially offer resistance against the detrimental effects of air pollution and changes in temperature in frail elderly adults with ACS. Future studies are needed to directly assess the interaction effect between the vaccination and environmental factors on ACS.

Original languageEnglish
Pages (from-to)6316-6322
Number of pages7
JournalVaccine
Volume34
Issue number50
DOIs
Publication statusPublished - 2016 Dec 7

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Air Pollution
air pollution
Acute Coronary Syndrome
influenza
Human Influenza
Vaccination
vaccination
weather
Weather
Taiwan
vaccines
health insurance
Influenza Vaccines
temperature
cold season
environmental protection
Temperature
humidity
risk factors
pollutants

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Huang, Ching Hui ; Chao, Day Yu ; Wu, Chao Chun ; Hsu, Shu Yun ; Soon, Maw Soan ; Chang, Chia Chu ; Kor, Chew Teng ; Chang, Wan Tzu ; Lian, Iebin. / Influenza vaccination and the endurance against air pollution among elderly with acute coronary syndrome. In: Vaccine. 2016 ; Vol. 34, No. 50. pp. 6316-6322.
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abstract = "Objective Air pollution, weather condition and influenza are known risk factors of acute coronary syndrome (ACS) among elderly people. The influenza vaccine (IV) has been shown to reduce major cardiovascular events. The purpose of this study was to compare resistance to air pollution and weather factors causing ACS between vaccinated and less-vaccinated elderly people. Methods A case–crossover design was applied to 1835 elderly ACS patients who were obtained from the 1-million sample of Taiwan National Health Insurance Research Data with inclusion criteria: (1) the first diagnosis of ACS was in cold season and at age 68 or more, (2) had received the free IV program at least once during the period 3 years before the ACS. They were stratified into two groups: 707 had received flu vaccinations for all the 3 years and the remaining 1128 had not. The measurements of air pollutants, temperature, and humidity corresponding to each of the 3 days prior to the ACS diagnosis date were retrieved from the data banks of the Taiwan Environmental Protection Administration and Central Weather Bureau. Findings Increases in air pollution concentrations of CO, NO2, PM10 or PM2.5 and decreases in temperature significantly influenced the risk of ACS for the non-continuously vaccinated elderly population; however, less significant effects were observed for the continuously vaccinated population. Conclusion Consecutive influenza vaccination may potentially offer resistance against the detrimental effects of air pollution and changes in temperature in frail elderly adults with ACS. Future studies are needed to directly assess the interaction effect between the vaccination and environmental factors on ACS.",
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Huang, CH, Chao, DY, Wu, CC, Hsu, SY, Soon, MS, Chang, CC, Kor, CT, Chang, WT & Lian, I 2016, 'Influenza vaccination and the endurance against air pollution among elderly with acute coronary syndrome', Vaccine, vol. 34, no. 50, pp. 6316-6322. https://doi.org/10.1016/j.vaccine.2016.10.054

Influenza vaccination and the endurance against air pollution among elderly with acute coronary syndrome. / Huang, Ching Hui; Chao, Day Yu; Wu, Chao Chun; Hsu, Shu Yun; Soon, Maw Soan; Chang, Chia Chu; Kor, Chew Teng; Chang, Wan Tzu; Lian, Iebin.

In: Vaccine, Vol. 34, No. 50, 07.12.2016, p. 6316-6322.

Research output: Contribution to journalArticle

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AU - Huang, Ching Hui

AU - Chao, Day Yu

AU - Wu, Chao Chun

AU - Hsu, Shu Yun

AU - Soon, Maw Soan

AU - Chang, Chia Chu

AU - Kor, Chew Teng

AU - Chang, Wan Tzu

AU - Lian, Iebin

PY - 2016/12/7

Y1 - 2016/12/7

N2 - Objective Air pollution, weather condition and influenza are known risk factors of acute coronary syndrome (ACS) among elderly people. The influenza vaccine (IV) has been shown to reduce major cardiovascular events. The purpose of this study was to compare resistance to air pollution and weather factors causing ACS between vaccinated and less-vaccinated elderly people. Methods A case–crossover design was applied to 1835 elderly ACS patients who were obtained from the 1-million sample of Taiwan National Health Insurance Research Data with inclusion criteria: (1) the first diagnosis of ACS was in cold season and at age 68 or more, (2) had received the free IV program at least once during the period 3 years before the ACS. They were stratified into two groups: 707 had received flu vaccinations for all the 3 years and the remaining 1128 had not. The measurements of air pollutants, temperature, and humidity corresponding to each of the 3 days prior to the ACS diagnosis date were retrieved from the data banks of the Taiwan Environmental Protection Administration and Central Weather Bureau. Findings Increases in air pollution concentrations of CO, NO2, PM10 or PM2.5 and decreases in temperature significantly influenced the risk of ACS for the non-continuously vaccinated elderly population; however, less significant effects were observed for the continuously vaccinated population. Conclusion Consecutive influenza vaccination may potentially offer resistance against the detrimental effects of air pollution and changes in temperature in frail elderly adults with ACS. Future studies are needed to directly assess the interaction effect between the vaccination and environmental factors on ACS.

AB - Objective Air pollution, weather condition and influenza are known risk factors of acute coronary syndrome (ACS) among elderly people. The influenza vaccine (IV) has been shown to reduce major cardiovascular events. The purpose of this study was to compare resistance to air pollution and weather factors causing ACS between vaccinated and less-vaccinated elderly people. Methods A case–crossover design was applied to 1835 elderly ACS patients who were obtained from the 1-million sample of Taiwan National Health Insurance Research Data with inclusion criteria: (1) the first diagnosis of ACS was in cold season and at age 68 or more, (2) had received the free IV program at least once during the period 3 years before the ACS. They were stratified into two groups: 707 had received flu vaccinations for all the 3 years and the remaining 1128 had not. The measurements of air pollutants, temperature, and humidity corresponding to each of the 3 days prior to the ACS diagnosis date were retrieved from the data banks of the Taiwan Environmental Protection Administration and Central Weather Bureau. Findings Increases in air pollution concentrations of CO, NO2, PM10 or PM2.5 and decreases in temperature significantly influenced the risk of ACS for the non-continuously vaccinated elderly population; however, less significant effects were observed for the continuously vaccinated population. Conclusion Consecutive influenza vaccination may potentially offer resistance against the detrimental effects of air pollution and changes in temperature in frail elderly adults with ACS. Future studies are needed to directly assess the interaction effect between the vaccination and environmental factors on ACS.

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