Increased risk of coronary heart disease in male patients with central serous chorioretinopathy: Results of a population-based cohort study

San Ni Chen, Yi Chiao Chen, Iebin Lian

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Aims: To investigate whether patients with central serous chorioretinopathy (CSCR) have increased risk of coronary heart disease (CHD). Methods: Population-based retrospective cohort and case control study. Longitudinal data from the Taiwan National Health Insurance Research Database (2000- 2009) were analysed. The study cohort comprised 835 patients with a diagnosis of CSCR and 4175 age and gender matched patients without CSCR. Kaplan-Meier plots and log-rank tests were used to compare differences in the hazard rates of CHD between the CSCR and non-CSCR cohorts. Stratified Cox proportional hazard models were applied to examine the association between CSCR and CHD, adjusting for potential confounding factors. Results: The 5-year CHD cumulative incidence for patients with CSCR was nearly twofold that of the non- CSCR cohort (6.12% vs 3.29%, p=0.004) from the logrank test. The adjusted CHD HR of CSCR versus non- CSCR was 1.61 (95% CI 1.12 to 2.30, p=0.009) from the Cox model. Speci fically, the HR for male patients was 1.72 (95% CI 1.14 to 2.59, p=0.010) and for female patients it was 1.34 (95% CI 0.64 to 2.84, p=0.438). Conclusions: Male patients with CSCR had a significantly higher CHD rate than those without CSCR, indicating that CSCR may be a potential risk factor for the development of CHD for men.

Original languageEnglish
Pages (from-to)110-114
Number of pages5
JournalBritish Journal of Ophthalmology
Volume98
Issue number1
DOIs
Publication statusPublished - 2014 Jan 1

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Central Serous Chorioretinopathy
Coronary Disease
Cohort Studies
Population
Proportional Hazards Models
National Health Programs
Taiwan
Case-Control Studies

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

@article{2550254c89504e10a199b809b4140eb2,
title = "Increased risk of coronary heart disease in male patients with central serous chorioretinopathy: Results of a population-based cohort study",
abstract = "Aims: To investigate whether patients with central serous chorioretinopathy (CSCR) have increased risk of coronary heart disease (CHD). Methods: Population-based retrospective cohort and case control study. Longitudinal data from the Taiwan National Health Insurance Research Database (2000- 2009) were analysed. The study cohort comprised 835 patients with a diagnosis of CSCR and 4175 age and gender matched patients without CSCR. Kaplan-Meier plots and log-rank tests were used to compare differences in the hazard rates of CHD between the CSCR and non-CSCR cohorts. Stratified Cox proportional hazard models were applied to examine the association between CSCR and CHD, adjusting for potential confounding factors. Results: The 5-year CHD cumulative incidence for patients with CSCR was nearly twofold that of the non- CSCR cohort (6.12{\%} vs 3.29{\%}, p=0.004) from the logrank test. The adjusted CHD HR of CSCR versus non- CSCR was 1.61 (95{\%} CI 1.12 to 2.30, p=0.009) from the Cox model. Speci fically, the HR for male patients was 1.72 (95{\%} CI 1.14 to 2.59, p=0.010) and for female patients it was 1.34 (95{\%} CI 0.64 to 2.84, p=0.438). Conclusions: Male patients with CSCR had a significantly higher CHD rate than those without CSCR, indicating that CSCR may be a potential risk factor for the development of CHD for men.",
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Increased risk of coronary heart disease in male patients with central serous chorioretinopathy : Results of a population-based cohort study. / Chen, San Ni; Chen, Yi Chiao; Lian, Iebin.

In: British Journal of Ophthalmology, Vol. 98, No. 1, 01.01.2014, p. 110-114.

Research output: Contribution to journalArticle

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N2 - Aims: To investigate whether patients with central serous chorioretinopathy (CSCR) have increased risk of coronary heart disease (CHD). Methods: Population-based retrospective cohort and case control study. Longitudinal data from the Taiwan National Health Insurance Research Database (2000- 2009) were analysed. The study cohort comprised 835 patients with a diagnosis of CSCR and 4175 age and gender matched patients without CSCR. Kaplan-Meier plots and log-rank tests were used to compare differences in the hazard rates of CHD between the CSCR and non-CSCR cohorts. Stratified Cox proportional hazard models were applied to examine the association between CSCR and CHD, adjusting for potential confounding factors. Results: The 5-year CHD cumulative incidence for patients with CSCR was nearly twofold that of the non- CSCR cohort (6.12% vs 3.29%, p=0.004) from the logrank test. The adjusted CHD HR of CSCR versus non- CSCR was 1.61 (95% CI 1.12 to 2.30, p=0.009) from the Cox model. Speci fically, the HR for male patients was 1.72 (95% CI 1.14 to 2.59, p=0.010) and for female patients it was 1.34 (95% CI 0.64 to 2.84, p=0.438). Conclusions: Male patients with CSCR had a significantly higher CHD rate than those without CSCR, indicating that CSCR may be a potential risk factor for the development of CHD for men.

AB - Aims: To investigate whether patients with central serous chorioretinopathy (CSCR) have increased risk of coronary heart disease (CHD). Methods: Population-based retrospective cohort and case control study. Longitudinal data from the Taiwan National Health Insurance Research Database (2000- 2009) were analysed. The study cohort comprised 835 patients with a diagnosis of CSCR and 4175 age and gender matched patients without CSCR. Kaplan-Meier plots and log-rank tests were used to compare differences in the hazard rates of CHD between the CSCR and non-CSCR cohorts. Stratified Cox proportional hazard models were applied to examine the association between CSCR and CHD, adjusting for potential confounding factors. Results: The 5-year CHD cumulative incidence for patients with CSCR was nearly twofold that of the non- CSCR cohort (6.12% vs 3.29%, p=0.004) from the logrank test. The adjusted CHD HR of CSCR versus non- CSCR was 1.61 (95% CI 1.12 to 2.30, p=0.009) from the Cox model. Speci fically, the HR for male patients was 1.72 (95% CI 1.14 to 2.59, p=0.010) and for female patients it was 1.34 (95% CI 0.64 to 2.84, p=0.438). Conclusions: Male patients with CSCR had a significantly higher CHD rate than those without CSCR, indicating that CSCR may be a potential risk factor for the development of CHD for men.

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