TY - JOUR
T1 - Increased risk of coronary heart disease in male patients with central serous chorioretinopathy
T2 - Results of a population-based cohort study
AU - Chen, San Ni
AU - Chen, Yi Chiao
AU - Lian, Iebin B.
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2014/1
Y1 - 2014/1
N2 - Aims: To investigate whether patients with central serous chorioretinopathy (CSCR) have increased risk of coronary heart disease (CHD). Methods: Population-based retrospective cohort and case control study. Longitudinal data from the Taiwan National Health Insurance Research Database (2000- 2009) were analysed. The study cohort comprised 835 patients with a diagnosis of CSCR and 4175 age and gender matched patients without CSCR. Kaplan-Meier plots and log-rank tests were used to compare differences in the hazard rates of CHD between the CSCR and non-CSCR cohorts. Stratified Cox proportional hazard models were applied to examine the association between CSCR and CHD, adjusting for potential confounding factors. Results: The 5-year CHD cumulative incidence for patients with CSCR was nearly twofold that of the non- CSCR cohort (6.12% vs 3.29%, p=0.004) from the logrank test. The adjusted CHD HR of CSCR versus non- CSCR was 1.61 (95% CI 1.12 to 2.30, p=0.009) from the Cox model. Speci fically, the HR for male patients was 1.72 (95% CI 1.14 to 2.59, p=0.010) and for female patients it was 1.34 (95% CI 0.64 to 2.84, p=0.438). Conclusions: Male patients with CSCR had a significantly higher CHD rate than those without CSCR, indicating that CSCR may be a potential risk factor for the development of CHD for men.
AB - Aims: To investigate whether patients with central serous chorioretinopathy (CSCR) have increased risk of coronary heart disease (CHD). Methods: Population-based retrospective cohort and case control study. Longitudinal data from the Taiwan National Health Insurance Research Database (2000- 2009) were analysed. The study cohort comprised 835 patients with a diagnosis of CSCR and 4175 age and gender matched patients without CSCR. Kaplan-Meier plots and log-rank tests were used to compare differences in the hazard rates of CHD between the CSCR and non-CSCR cohorts. Stratified Cox proportional hazard models were applied to examine the association between CSCR and CHD, adjusting for potential confounding factors. Results: The 5-year CHD cumulative incidence for patients with CSCR was nearly twofold that of the non- CSCR cohort (6.12% vs 3.29%, p=0.004) from the logrank test. The adjusted CHD HR of CSCR versus non- CSCR was 1.61 (95% CI 1.12 to 2.30, p=0.009) from the Cox model. Speci fically, the HR for male patients was 1.72 (95% CI 1.14 to 2.59, p=0.010) and for female patients it was 1.34 (95% CI 0.64 to 2.84, p=0.438). Conclusions: Male patients with CSCR had a significantly higher CHD rate than those without CSCR, indicating that CSCR may be a potential risk factor for the development of CHD for men.
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U2 - 10.1136/bjophthalmol-2013-303945
DO - 10.1136/bjophthalmol-2013-303945
M3 - Article
C2 - 24169652
AN - SCOPUS:84890565502
VL - 98
SP - 110
EP - 114
JO - British Journal of Ophthalmology
JF - British Journal of Ophthalmology
SN - 0007-1161
IS - 1
ER -