Incidence of oral cancer in relation to nickel and arsenic concentrations in farm soils of patients' residential areas in Taiwan

Che Chun Su, Yo Yu Lin, Tsun Kuo Chang, Chi Ting Chiang, Jian An Chung, Yun Ying Hsu, Ie Bin Lian

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Background. To explore if exposures to specific heavy metals in the environment is a new risk factor of oral cancer, one of the fastest growing malignancies in Taiwan, in addition to the two established risk factors, cigarette smoking and betel quid chewing. Methods. This is an observational study utilized the age-standardized incidence rates of oral cancer in the 316 townships and precincts of Taiwan, local prevalence rates of cigarette smoking and betel quid chewing, demographic factors, socio-economic conditions, and concentrations in farm soils of the eight kinds of heavy metal. Spatial regression and GIS (Geographic Information System) were used. The registration contained 22,083 patients, who were diagnosed with oral cancer between 1982 and 2002. The concentrations of metal in the soils were retrieved from a nation-wide survey in the 1980s. Results. The incidence rate of oral cancer is geographically related to the concentrations of arsenic and nickel in the patients' residential areas, with the prevalence of cigarette smoking and betel quid chewing as controlled variables. Conclusions. Beside the two established risk factors, cigarette smoking and betel quid chewing, arsenic and nickel in farm soils may be new risk factors for oral cancer. These two kinds of metal may involve in the development of oral cancer. Further studies are required to understand the pathways via which metal in the farm soils exerts its effects on human health.

Original languageEnglish
Article number67
JournalBMC Public Health
Volume10
DOIs
Publication statusPublished - 2010 Mar 19

Fingerprint

Mouth Neoplasms
Arsenic
Nickel
Taiwan
Soil
Mastication
Incidence
Smoking
Metals
Heavy Metals
Geographic Information Systems
Observational Studies
Farms
Economics
Demography
Health
Neoplasms

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

Cite this

Su, Che Chun ; Lin, Yo Yu ; Chang, Tsun Kuo ; Chiang, Chi Ting ; Chung, Jian An ; Hsu, Yun Ying ; Lian, Ie Bin. / Incidence of oral cancer in relation to nickel and arsenic concentrations in farm soils of patients' residential areas in Taiwan. In: BMC Public Health. 2010 ; Vol. 10.
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abstract = "Background. To explore if exposures to specific heavy metals in the environment is a new risk factor of oral cancer, one of the fastest growing malignancies in Taiwan, in addition to the two established risk factors, cigarette smoking and betel quid chewing. Methods. This is an observational study utilized the age-standardized incidence rates of oral cancer in the 316 townships and precincts of Taiwan, local prevalence rates of cigarette smoking and betel quid chewing, demographic factors, socio-economic conditions, and concentrations in farm soils of the eight kinds of heavy metal. Spatial regression and GIS (Geographic Information System) were used. The registration contained 22,083 patients, who were diagnosed with oral cancer between 1982 and 2002. The concentrations of metal in the soils were retrieved from a nation-wide survey in the 1980s. Results. The incidence rate of oral cancer is geographically related to the concentrations of arsenic and nickel in the patients' residential areas, with the prevalence of cigarette smoking and betel quid chewing as controlled variables. Conclusions. Beside the two established risk factors, cigarette smoking and betel quid chewing, arsenic and nickel in farm soils may be new risk factors for oral cancer. These two kinds of metal may involve in the development of oral cancer. Further studies are required to understand the pathways via which metal in the farm soils exerts its effects on human health.",
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Incidence of oral cancer in relation to nickel and arsenic concentrations in farm soils of patients' residential areas in Taiwan. / Su, Che Chun; Lin, Yo Yu; Chang, Tsun Kuo; Chiang, Chi Ting; Chung, Jian An; Hsu, Yun Ying; Lian, Ie Bin.

In: BMC Public Health, Vol. 10, 67, 19.03.2010.

Research output: Contribution to journalArticle

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