Abstract
Background A number of cross-sectional studies have suggested that higher levels of sedentary behavior (SB) are associated with worse cognitive abilities in older age. There is a paucity of longitudinal studies investigating this relationship utilizing objectively assessed SB. This study investigated the relationship between objectively assessed SB and future cognitive abilities in a cohort of older adults. Methods A longitudinal study over 22.12 ± 1.46 months including 285 community-dwelling older adults across 14 regions in Taiwan was undertaken. Cognitive ability was ascertained using a Chinese version of the Ascertain Dementia 8-item Questionnaire (AD8) and SB captured by 7 days accelerometer data. Multivariable negative binomial regression models adjusted for confounders were undertaken. Results 274 community-dwelling older adults finished the study (age = 74.6 ± 6.2, % female = 54.4%). At baseline, 20.1% (n = 55), 48.5% (n = 133) and 31.4% (n = 86) of the sample engaged in high (11+ h), medium (7–10.99 h) and low (< 7 h) of SB respectively. In the fully adjusted model, higher levels of SB were associated with an increased risk of worse cognitive ability at follow up (adjusted rate ratio (ARR)1.09 (95%CI:1.00–1.19)), with the strongest relationship evident in those engaging in over 11 h of SB (ARR 2.27 (95%CI:1.24–4.16)). The relationship remained evident after adjusting for depressive symptoms and physical activity. Conclusion Our data suggests that objectively assessed SB, particularly when over 11 h a day, is independently associated with worse cognitive ability over a two year period. Our data adds to the pressing reasons to reduced SB in older age.
| Original language | English |
|---|---|
| Pages (from-to) | 110-114 |
| Number of pages | 5 |
| Journal | Experimental Gerontology |
| Volume | 99 |
| DOIs | |
| Publication status | Published - 2017 Dec 1 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Ageing
- Molecular Biology
- Genetics
- Endocrinology
- Cell Biology
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Higher levels of objectively measured sedentary behavior is associated with worse cognitive ability : Two-year follow-up study in community-dwelling older adults. / Ku, Po Wen; Liu, Yi Te; Lo, Ming Kuei; Chen, Li Jung; Stubbs, Brendon.
In: Experimental Gerontology, Vol. 99, 01.12.2017, p. 110-114.Research output: Contribution to journal › Article
TY - JOUR
T1 - Higher levels of objectively measured sedentary behavior is associated with worse cognitive ability
T2 - Two-year follow-up study in community-dwelling older adults
AU - Ku, Po Wen
AU - Liu, Yi Te
AU - Lo, Ming Kuei
AU - Chen, Li Jung
AU - Stubbs, Brendon
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Background A number of cross-sectional studies have suggested that higher levels of sedentary behavior (SB) are associated with worse cognitive abilities in older age. There is a paucity of longitudinal studies investigating this relationship utilizing objectively assessed SB. This study investigated the relationship between objectively assessed SB and future cognitive abilities in a cohort of older adults. Methods A longitudinal study over 22.12 ± 1.46 months including 285 community-dwelling older adults across 14 regions in Taiwan was undertaken. Cognitive ability was ascertained using a Chinese version of the Ascertain Dementia 8-item Questionnaire (AD8) and SB captured by 7 days accelerometer data. Multivariable negative binomial regression models adjusted for confounders were undertaken. Results 274 community-dwelling older adults finished the study (age = 74.6 ± 6.2, % female = 54.4%). At baseline, 20.1% (n = 55), 48.5% (n = 133) and 31.4% (n = 86) of the sample engaged in high (11+ h), medium (7–10.99 h) and low (< 7 h) of SB respectively. In the fully adjusted model, higher levels of SB were associated with an increased risk of worse cognitive ability at follow up (adjusted rate ratio (ARR)1.09 (95%CI:1.00–1.19)), with the strongest relationship evident in those engaging in over 11 h of SB (ARR 2.27 (95%CI:1.24–4.16)). The relationship remained evident after adjusting for depressive symptoms and physical activity. Conclusion Our data suggests that objectively assessed SB, particularly when over 11 h a day, is independently associated with worse cognitive ability over a two year period. Our data adds to the pressing reasons to reduced SB in older age.
AB - Background A number of cross-sectional studies have suggested that higher levels of sedentary behavior (SB) are associated with worse cognitive abilities in older age. There is a paucity of longitudinal studies investigating this relationship utilizing objectively assessed SB. This study investigated the relationship between objectively assessed SB and future cognitive abilities in a cohort of older adults. Methods A longitudinal study over 22.12 ± 1.46 months including 285 community-dwelling older adults across 14 regions in Taiwan was undertaken. Cognitive ability was ascertained using a Chinese version of the Ascertain Dementia 8-item Questionnaire (AD8) and SB captured by 7 days accelerometer data. Multivariable negative binomial regression models adjusted for confounders were undertaken. Results 274 community-dwelling older adults finished the study (age = 74.6 ± 6.2, % female = 54.4%). At baseline, 20.1% (n = 55), 48.5% (n = 133) and 31.4% (n = 86) of the sample engaged in high (11+ h), medium (7–10.99 h) and low (< 7 h) of SB respectively. In the fully adjusted model, higher levels of SB were associated with an increased risk of worse cognitive ability at follow up (adjusted rate ratio (ARR)1.09 (95%CI:1.00–1.19)), with the strongest relationship evident in those engaging in over 11 h of SB (ARR 2.27 (95%CI:1.24–4.16)). The relationship remained evident after adjusting for depressive symptoms and physical activity. Conclusion Our data suggests that objectively assessed SB, particularly when over 11 h a day, is independently associated with worse cognitive ability over a two year period. Our data adds to the pressing reasons to reduced SB in older age.
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UR - http://www.scopus.com/inward/citedby.url?scp=85030316083&partnerID=8YFLogxK
U2 - 10.1016/j.exger.2017.09.014
DO - 10.1016/j.exger.2017.09.014
M3 - Article
C2 - 28962854
AN - SCOPUS:85030316083
VL - 99
SP - 110
EP - 114
JO - Experimental Gerontology
JF - Experimental Gerontology
SN - 0531-5565
ER -