Higher levels of objectively measured sedentary behavior is associated with worse cognitive ability: Two-year follow-up study in community-dwelling older adults

Po Wen Ku, Yi Te Liu, Ming Kuei Lo, Li Jung Chen, Brendon Stubbs

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background A number of cross-sectional studies have suggested that higher levels of sedentary behavior (SB) are associated with worse cognitive abilities in older age. There is a paucity of longitudinal studies investigating this relationship utilizing objectively assessed SB. This study investigated the relationship between objectively assessed SB and future cognitive abilities in a cohort of older adults. Methods A longitudinal study over 22.12 ± 1.46 months including 285 community-dwelling older adults across 14 regions in Taiwan was undertaken. Cognitive ability was ascertained using a Chinese version of the Ascertain Dementia 8-item Questionnaire (AD8) and SB captured by 7 days accelerometer data. Multivariable negative binomial regression models adjusted for confounders were undertaken. Results 274 community-dwelling older adults finished the study (age = 74.6 ± 6.2, % female = 54.4%). At baseline, 20.1% (n = 55), 48.5% (n = 133) and 31.4% (n = 86) of the sample engaged in high (11+ h), medium (7–10.99 h) and low (< 7 h) of SB respectively. In the fully adjusted model, higher levels of SB were associated with an increased risk of worse cognitive ability at follow up (adjusted rate ratio (ARR)1.09 (95%CI:1.00–1.19)), with the strongest relationship evident in those engaging in over 11 h of SB (ARR 2.27 (95%CI:1.24–4.16)). The relationship remained evident after adjusting for depressive symptoms and physical activity. Conclusion Our data suggests that objectively assessed SB, particularly when over 11 h a day, is independently associated with worse cognitive ability over a two year period. Our data adds to the pressing reasons to reduced SB in older age.

Original languageEnglish
Pages (from-to)110-114
Number of pages5
JournalExperimental Gerontology
Volume99
DOIs
Publication statusPublished - 2017 Dec 1

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Independent Living
Aptitude
Accelerometers
Longitudinal Studies
Statistical Models
Taiwan
Dementia
Cross-Sectional Studies
Depression

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Ageing
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Cell Biology

Cite this

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title = "Higher levels of objectively measured sedentary behavior is associated with worse cognitive ability: Two-year follow-up study in community-dwelling older adults",
abstract = "Background A number of cross-sectional studies have suggested that higher levels of sedentary behavior (SB) are associated with worse cognitive abilities in older age. There is a paucity of longitudinal studies investigating this relationship utilizing objectively assessed SB. This study investigated the relationship between objectively assessed SB and future cognitive abilities in a cohort of older adults. Methods A longitudinal study over 22.12 ± 1.46 months including 285 community-dwelling older adults across 14 regions in Taiwan was undertaken. Cognitive ability was ascertained using a Chinese version of the Ascertain Dementia 8-item Questionnaire (AD8) and SB captured by 7 days accelerometer data. Multivariable negative binomial regression models adjusted for confounders were undertaken. Results 274 community-dwelling older adults finished the study (age = 74.6 ± 6.2, {\%} female = 54.4{\%}). At baseline, 20.1{\%} (n = 55), 48.5{\%} (n = 133) and 31.4{\%} (n = 86) of the sample engaged in high (11+ h), medium (7–10.99 h) and low (< 7 h) of SB respectively. In the fully adjusted model, higher levels of SB were associated with an increased risk of worse cognitive ability at follow up (adjusted rate ratio (ARR)1.09 (95{\%}CI:1.00–1.19)), with the strongest relationship evident in those engaging in over 11 h of SB (ARR 2.27 (95{\%}CI:1.24–4.16)). The relationship remained evident after adjusting for depressive symptoms and physical activity. Conclusion Our data suggests that objectively assessed SB, particularly when over 11 h a day, is independently associated with worse cognitive ability over a two year period. Our data adds to the pressing reasons to reduced SB in older age.",
author = "Ku, {Po Wen} and Liu, {Yi Te} and Lo, {Ming Kuei} and Chen, {Li Jung} and Brendon Stubbs",
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Higher levels of objectively measured sedentary behavior is associated with worse cognitive ability : Two-year follow-up study in community-dwelling older adults. / Ku, Po Wen; Liu, Yi Te; Lo, Ming Kuei; Chen, Li Jung; Stubbs, Brendon.

In: Experimental Gerontology, Vol. 99, 01.12.2017, p. 110-114.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Higher levels of objectively measured sedentary behavior is associated with worse cognitive ability

T2 - Two-year follow-up study in community-dwelling older adults

AU - Ku, Po Wen

AU - Liu, Yi Te

AU - Lo, Ming Kuei

AU - Chen, Li Jung

AU - Stubbs, Brendon

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Background A number of cross-sectional studies have suggested that higher levels of sedentary behavior (SB) are associated with worse cognitive abilities in older age. There is a paucity of longitudinal studies investigating this relationship utilizing objectively assessed SB. This study investigated the relationship between objectively assessed SB and future cognitive abilities in a cohort of older adults. Methods A longitudinal study over 22.12 ± 1.46 months including 285 community-dwelling older adults across 14 regions in Taiwan was undertaken. Cognitive ability was ascertained using a Chinese version of the Ascertain Dementia 8-item Questionnaire (AD8) and SB captured by 7 days accelerometer data. Multivariable negative binomial regression models adjusted for confounders were undertaken. Results 274 community-dwelling older adults finished the study (age = 74.6 ± 6.2, % female = 54.4%). At baseline, 20.1% (n = 55), 48.5% (n = 133) and 31.4% (n = 86) of the sample engaged in high (11+ h), medium (7–10.99 h) and low (< 7 h) of SB respectively. In the fully adjusted model, higher levels of SB were associated with an increased risk of worse cognitive ability at follow up (adjusted rate ratio (ARR)1.09 (95%CI:1.00–1.19)), with the strongest relationship evident in those engaging in over 11 h of SB (ARR 2.27 (95%CI:1.24–4.16)). The relationship remained evident after adjusting for depressive symptoms and physical activity. Conclusion Our data suggests that objectively assessed SB, particularly when over 11 h a day, is independently associated with worse cognitive ability over a two year period. Our data adds to the pressing reasons to reduced SB in older age.

AB - Background A number of cross-sectional studies have suggested that higher levels of sedentary behavior (SB) are associated with worse cognitive abilities in older age. There is a paucity of longitudinal studies investigating this relationship utilizing objectively assessed SB. This study investigated the relationship between objectively assessed SB and future cognitive abilities in a cohort of older adults. Methods A longitudinal study over 22.12 ± 1.46 months including 285 community-dwelling older adults across 14 regions in Taiwan was undertaken. Cognitive ability was ascertained using a Chinese version of the Ascertain Dementia 8-item Questionnaire (AD8) and SB captured by 7 days accelerometer data. Multivariable negative binomial regression models adjusted for confounders were undertaken. Results 274 community-dwelling older adults finished the study (age = 74.6 ± 6.2, % female = 54.4%). At baseline, 20.1% (n = 55), 48.5% (n = 133) and 31.4% (n = 86) of the sample engaged in high (11+ h), medium (7–10.99 h) and low (< 7 h) of SB respectively. In the fully adjusted model, higher levels of SB were associated with an increased risk of worse cognitive ability at follow up (adjusted rate ratio (ARR)1.09 (95%CI:1.00–1.19)), with the strongest relationship evident in those engaging in over 11 h of SB (ARR 2.27 (95%CI:1.24–4.16)). The relationship remained evident after adjusting for depressive symptoms and physical activity. Conclusion Our data suggests that objectively assessed SB, particularly when over 11 h a day, is independently associated with worse cognitive ability over a two year period. Our data adds to the pressing reasons to reduced SB in older age.

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