Heavy alcohol consumption increases the risk of active tuberculosis in Taiwanese adults: a nation-wide population-based cohort study

Yung Feng Yen, Hsiao Yun Hu, Ya Ling Lee, Po-Wen Ku, Pei Hung Chuang, Yun Ju Lai, Dachen Chu

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Aims: To investigate the impact of alcohol exposure on tuberculosis (TB) development in Taiwanese adults. Design: Participants from the Taiwan National Health Interview Survey. Alcohol consumption and other covariates were collected by in-person interviews at baseline. Incident cases of active TB were identified from the National Health Insurance database. A multivariable Cox regression model was used to estimate the association between alcohol consumption and active TB, with adjustment for age, sex, smoking, socio-economic status and other covariates. Setting: Taiwan National Health Interview Survey. Participants: A total of 46 196 adult participants aged ≥ 18 years from three rounds (2001, 2005, 2009) of the Taiwan National Health Interview Survey. Measurements: Alcohol consumption was classified into never, social, regular or heavy alcohol use. Heavy alcohol consumption was defined as intoxication at least once/week. Findings: Of the 46 196 study subjects, 61.8, 24.2, 13.5 and 0.5% were classified as never, social, regular and heavy alcohol users, respectively. During the 398 443 person-years of follow-up, 279 (0.60%) subjects developed new-onset active TB. After adjusting for the subject demographics and comorbidities, heavy [hazard ratio (HR) = 5.27; 95% confidence interval (CI) = 2.51–11.09] and regular alcohol users (HR = 1.80; 95% CI = 1.32–2.45) had increased risks of incident TB compared to never users. Moreover, a positive trend between increasing levels of alcohol consumption and the risk of active TB was noted (P < 0.001). Conclusions: In Taiwan, heavy and regular alcohol consumption are associated with higher risks of active tuberculosis.

Original languageEnglish
Pages (from-to)2124-2131
Number of pages8
JournalAddiction
Volume112
Issue number12
DOIs
Publication statusPublished - 2017 Dec 1

Fingerprint

Alcohol Drinking
Tuberculosis
Cohort Studies
Taiwan
Population
Health Surveys
Alcohols
Interviews
Confidence Intervals
National Health Programs
Proportional Hazards Models
Comorbidity
Smoking
Economics
Demography
Databases

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Psychiatry and Mental health

Cite this

Yen, Yung Feng ; Hu, Hsiao Yun ; Lee, Ya Ling ; Ku, Po-Wen ; Chuang, Pei Hung ; Lai, Yun Ju ; Chu, Dachen. / Heavy alcohol consumption increases the risk of active tuberculosis in Taiwanese adults : a nation-wide population-based cohort study. In: Addiction. 2017 ; Vol. 112, No. 12. pp. 2124-2131.
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title = "Heavy alcohol consumption increases the risk of active tuberculosis in Taiwanese adults: a nation-wide population-based cohort study",
abstract = "Aims: To investigate the impact of alcohol exposure on tuberculosis (TB) development in Taiwanese adults. Design: Participants from the Taiwan National Health Interview Survey. Alcohol consumption and other covariates were collected by in-person interviews at baseline. Incident cases of active TB were identified from the National Health Insurance database. A multivariable Cox regression model was used to estimate the association between alcohol consumption and active TB, with adjustment for age, sex, smoking, socio-economic status and other covariates. Setting: Taiwan National Health Interview Survey. Participants: A total of 46 196 adult participants aged ≥ 18 years from three rounds (2001, 2005, 2009) of the Taiwan National Health Interview Survey. Measurements: Alcohol consumption was classified into never, social, regular or heavy alcohol use. Heavy alcohol consumption was defined as intoxication at least once/week. Findings: Of the 46 196 study subjects, 61.8, 24.2, 13.5 and 0.5{\%} were classified as never, social, regular and heavy alcohol users, respectively. During the 398 443 person-years of follow-up, 279 (0.60{\%}) subjects developed new-onset active TB. After adjusting for the subject demographics and comorbidities, heavy [hazard ratio (HR) = 5.27; 95{\%} confidence interval (CI) = 2.51–11.09] and regular alcohol users (HR = 1.80; 95{\%} CI = 1.32–2.45) had increased risks of incident TB compared to never users. Moreover, a positive trend between increasing levels of alcohol consumption and the risk of active TB was noted (P < 0.001). Conclusions: In Taiwan, heavy and regular alcohol consumption are associated with higher risks of active tuberculosis.",
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Heavy alcohol consumption increases the risk of active tuberculosis in Taiwanese adults : a nation-wide population-based cohort study. / Yen, Yung Feng; Hu, Hsiao Yun; Lee, Ya Ling; Ku, Po-Wen; Chuang, Pei Hung; Lai, Yun Ju; Chu, Dachen.

In: Addiction, Vol. 112, No. 12, 01.12.2017, p. 2124-2131.

Research output: Contribution to journalArticle

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AU - Yen, Yung Feng

AU - Hu, Hsiao Yun

AU - Lee, Ya Ling

AU - Ku, Po-Wen

AU - Chuang, Pei Hung

AU - Lai, Yun Ju

AU - Chu, Dachen

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N2 - Aims: To investigate the impact of alcohol exposure on tuberculosis (TB) development in Taiwanese adults. Design: Participants from the Taiwan National Health Interview Survey. Alcohol consumption and other covariates were collected by in-person interviews at baseline. Incident cases of active TB were identified from the National Health Insurance database. A multivariable Cox regression model was used to estimate the association between alcohol consumption and active TB, with adjustment for age, sex, smoking, socio-economic status and other covariates. Setting: Taiwan National Health Interview Survey. Participants: A total of 46 196 adult participants aged ≥ 18 years from three rounds (2001, 2005, 2009) of the Taiwan National Health Interview Survey. Measurements: Alcohol consumption was classified into never, social, regular or heavy alcohol use. Heavy alcohol consumption was defined as intoxication at least once/week. Findings: Of the 46 196 study subjects, 61.8, 24.2, 13.5 and 0.5% were classified as never, social, regular and heavy alcohol users, respectively. During the 398 443 person-years of follow-up, 279 (0.60%) subjects developed new-onset active TB. After adjusting for the subject demographics and comorbidities, heavy [hazard ratio (HR) = 5.27; 95% confidence interval (CI) = 2.51–11.09] and regular alcohol users (HR = 1.80; 95% CI = 1.32–2.45) had increased risks of incident TB compared to never users. Moreover, a positive trend between increasing levels of alcohol consumption and the risk of active TB was noted (P < 0.001). Conclusions: In Taiwan, heavy and regular alcohol consumption are associated with higher risks of active tuberculosis.

AB - Aims: To investigate the impact of alcohol exposure on tuberculosis (TB) development in Taiwanese adults. Design: Participants from the Taiwan National Health Interview Survey. Alcohol consumption and other covariates were collected by in-person interviews at baseline. Incident cases of active TB were identified from the National Health Insurance database. A multivariable Cox regression model was used to estimate the association between alcohol consumption and active TB, with adjustment for age, sex, smoking, socio-economic status and other covariates. Setting: Taiwan National Health Interview Survey. Participants: A total of 46 196 adult participants aged ≥ 18 years from three rounds (2001, 2005, 2009) of the Taiwan National Health Interview Survey. Measurements: Alcohol consumption was classified into never, social, regular or heavy alcohol use. Heavy alcohol consumption was defined as intoxication at least once/week. Findings: Of the 46 196 study subjects, 61.8, 24.2, 13.5 and 0.5% were classified as never, social, regular and heavy alcohol users, respectively. During the 398 443 person-years of follow-up, 279 (0.60%) subjects developed new-onset active TB. After adjusting for the subject demographics and comorbidities, heavy [hazard ratio (HR) = 5.27; 95% confidence interval (CI) = 2.51–11.09] and regular alcohol users (HR = 1.80; 95% CI = 1.32–2.45) had increased risks of incident TB compared to never users. Moreover, a positive trend between increasing levels of alcohol consumption and the risk of active TB was noted (P < 0.001). Conclusions: In Taiwan, heavy and regular alcohol consumption are associated with higher risks of active tuberculosis.

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