Halogenated Sesquiterpenoids from the Red Alga Laurencia tristicha Collected in Taiwan

Jia Yu Chen, Chiung Yao Huang, Yun Sheng Lin, Tsong Long Hwang, Wei Lung Wang, Shu Fen Chiou, Jyh Horng Sheu

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Chemical investigation of the red alga Laurencia tristicha led to the discovery of eight new halogenated chamigrane-type sesquiterpenoids (1-8) and one new bromocuparane-type sesquiterpene (9), along with nine known related metabolites (10-18). Their structures were elucidated on the basis of extensive spectroscopic analyses, and the absolute configurations of 1-8 were proposed by comparison to the biosynthetically related known compound 12. Cytotoxicity, antibacterial, and anti-inflammatory activities of these isolates were also investigated. The results showed that compound 11 exhibited good antibacterial activity against Serratia marcescens compared to the positive control ampicillin at a dosage of 100 μg/disk. Compound 17 showed strong inhibition toward elastase release generation at 10 μM.

Original languageEnglish
Pages (from-to)2315-2323
Number of pages9
JournalJournal of Natural Products
Volume79
Issue number9
DOIs
Publication statusPublished - 2016 Sep 23

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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