Gold nanosponges: Green synthesis, characterization, and cytotoxicity

Yang Wei Lin, Yi Cheng Chen, Chia Wei Wang, Wen Tsen Chen, Chao Ming Liu, Chung Yu Chen, Huan Tsung Chang

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


A simply approach for the synthesis of Au nanostructures in tea infusions at room temperature is developed. By controlling the concentrations of tea infusions, Au nanostructures in various shapes and sizes have been prepared. From 1× (original concentration) and 0.01×(100 times diluted) tea infusions, 52.2±8.1 nm Au nanosponges (T-Au NSs) and 23±2 nm spherical Au nanoparticles (T-Au NPs) were prepared. The phytochemicals present on the surface of T-Au NSs were proved by surface-assisted laser desorption/ionization mass spectrometry, Fourier transform infrared spectrometry and capillary electrophoresis coupled with UV detection. The energy-dispersive X-ray spectroscopy and powder X-ray diffraction data reveal pure crystalline structures of the T-Au NSs. The dark field scattering images observe that the T-Au NSs have significant affinity toward HeLa cells. The cytotoxicity of T-Au NSs on HeLa cells is through caspase-3 activation.

Original languageEnglish
Pages (from-to)6566-6574
Number of pages9
JournalJournal of Nanoscience and Nanotechnology
Issue number10
Publication statusPublished - 2013 Oct 1

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)
  • Condensed Matter Physics

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