Glycosylated nordihydroguaiaretic acids as anti-cancer agents

Jih Ru Hwu, Chuan I. Hsu, Ming Hua Hsu, Yu Chuan Liang, Ru Chih C. Huang, Yuan C. Lee

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Three perglycosylated nordihydroguaiaretic acids (NDGA) were synthesized through the Huiseng 1,3-dipolar cycloaddition reaction. These sugar-NDGA conjugates containing triazole-linkages possessed good solubility in water. NDGA-(triazol-galactose)4 (12b) and NDGA-(triazol-glucose) 4 (12c) were found to act as inhibitors against human hepatocellular carcinoma Hep3B cells in culture.

Original languageEnglish
Pages (from-to)380-382
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Issue number1
Publication statusPublished - 2011 Jan 1

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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