Glycosylated nordihydroguaiaretic acids as anti-cancer agents

Jih Ru Hwu, Chuan I. Hsu, Ming-Hua Hsu, Yu Chuan Liang, Ru Chih C. Huang, Yuan C. Lee

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Three perglycosylated nordihydroguaiaretic acids (NDGA) were synthesized through the Huiseng 1,3-dipolar cycloaddition reaction. These sugar-NDGA conjugates containing triazole-linkages possessed good solubility in water. NDGA-(triazol-galactose)4 (12b) and NDGA-(triazol-glucose) 4 (12c) were found to act as inhibitors against human hepatocellular carcinoma Hep3B cells in culture.

Original languageEnglish
Pages (from-to)380-382
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume21
Issue number1
DOIs
Publication statusPublished - 2011 Jan 1

Fingerprint

Masoprocol
Neoplasms
Sugar Acids
Triazoles
Cycloaddition
Cycloaddition Reaction
Galactose
Solubility
Hepatocellular Carcinoma
Cell Culture Techniques
Glucose
Water

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Hwu, Jih Ru ; Hsu, Chuan I. ; Hsu, Ming-Hua ; Liang, Yu Chuan ; Huang, Ru Chih C. ; Lee, Yuan C. / Glycosylated nordihydroguaiaretic acids as anti-cancer agents. In: Bioorganic and Medicinal Chemistry Letters. 2011 ; Vol. 21, No. 1. pp. 380-382.
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Glycosylated nordihydroguaiaretic acids as anti-cancer agents. / Hwu, Jih Ru; Hsu, Chuan I.; Hsu, Ming-Hua; Liang, Yu Chuan; Huang, Ru Chih C.; Lee, Yuan C.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 21, No. 1, 01.01.2011, p. 380-382.

Research output: Contribution to journalArticle

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