Abstract
Three perglycosylated nordihydroguaiaretic acids (NDGA) were synthesized through the Huiseng 1,3-dipolar cycloaddition reaction. These sugar-NDGA conjugates containing triazole-linkages possessed good solubility in water. NDGA-(triazol-galactose)4 (12b) and NDGA-(triazol-glucose) 4 (12c) were found to act as inhibitors against human hepatocellular carcinoma Hep3B cells in culture.
| Original language | English |
|---|---|
| Pages (from-to) | 380-382 |
| Number of pages | 3 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 21 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2011 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry
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Glycosylated nordihydroguaiaretic acids as anti-cancer agents. / Hwu, Jih Ru; Hsu, Chuan I.; Hsu, Ming-Hua; Liang, Yu Chuan; Huang, Ru Chih C.; Lee, Yuan C.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 21, No. 1, 01.01.2011, p. 380-382.Research output: Contribution to journal › Article
TY - JOUR
T1 - Glycosylated nordihydroguaiaretic acids as anti-cancer agents
AU - Hwu, Jih Ru
AU - Hsu, Chuan I.
AU - Hsu, Ming-Hua
AU - Liang, Yu Chuan
AU - Huang, Ru Chih C.
AU - Lee, Yuan C.
PY - 2011/1/1
Y1 - 2011/1/1
N2 - Three perglycosylated nordihydroguaiaretic acids (NDGA) were synthesized through the Huiseng 1,3-dipolar cycloaddition reaction. These sugar-NDGA conjugates containing triazole-linkages possessed good solubility in water. NDGA-(triazol-galactose)4 (12b) and NDGA-(triazol-glucose) 4 (12c) were found to act as inhibitors against human hepatocellular carcinoma Hep3B cells in culture.
AB - Three perglycosylated nordihydroguaiaretic acids (NDGA) were synthesized through the Huiseng 1,3-dipolar cycloaddition reaction. These sugar-NDGA conjugates containing triazole-linkages possessed good solubility in water. NDGA-(triazol-galactose)4 (12b) and NDGA-(triazol-glucose) 4 (12c) were found to act as inhibitors against human hepatocellular carcinoma Hep3B cells in culture.
UR - http://www.scopus.com/inward/record.url?scp=78650510386&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78650510386&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2010.10.137
DO - 10.1016/j.bmcl.2010.10.137
M3 - Article
C2 - 21123067
AN - SCOPUS:78650510386
VL - 21
SP - 380
EP - 382
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 1
ER -