Glycosylated nordihydroguaiaretic acids as anti-cancer agents

Jih Ru Hwu; Chuan I. Hsu; Ming Hua Hsu; Yu Chuan Liang; Ru Chih C. Huang; Yuan C. Lee

doi:10.1016/j.bmcl.2010.10.137

Glycosylated nordihydroguaiaretic acids as anti-cancer agents

Jih Ru Hwu, Chuan I. Hsu, Ming Hua Hsu, Yu Chuan Liang, Ru Chih C. Huang, Yuan C. Lee

Department of Chemistry

Research output: Contribution to journal › Article

14 Citations (Scopus)

Abstract

Three perglycosylated nordihydroguaiaretic acids (NDGA) were synthesized through the Huiseng 1,3-dipolar cycloaddition reaction. These sugar-NDGA conjugates containing triazole-linkages possessed good solubility in water. NDGA-(triazol-galactose)₄ (12b) and NDGA-(triazol-glucose) ₄ (12c) were found to act as inhibitors against human hepatocellular carcinoma Hep3B cells in culture.

Original language	English
Pages (from-to)	380-382
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	21
Issue number	1
DOIs	https://doi.org/10.1016/j.bmcl.2010.10.137
Publication status	Published - 2011 Jan 1

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All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Cite this

Hwu, J. R., Hsu, C. I., Hsu, M. H., Liang, Y. C., Huang, R. C. C., & Lee, Y. C. (2011). Glycosylated nordihydroguaiaretic acids as anti-cancer agents. Bioorganic and Medicinal Chemistry Letters, 21(1), 380-382. https://doi.org/10.1016/j.bmcl.2010.10.137

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10.1016/j.bmcl.2010.10.137