Glycosylated nordihydroguaiaretic acids as anti-cancer agents

Jih Ru Hwu; Chuan I. Hsu; Ming Hua Hsu; Yu Chuan Liang; Ru Chih C. Huang; Yuan C. Lee

doi:10.1016/j.bmcl.2010.10.137

Glycosylated nordihydroguaiaretic acids as anti-cancer agents

Jih Ru Hwu, Chuan I. Hsu, Ming Hua Hsu, Yu Chuan Liang, Ru Chih C. Huang, Yuan C. Lee

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Three perglycosylated nordihydroguaiaretic acids (NDGA) were synthesized through the Huiseng 1,3-dipolar cycloaddition reaction. These sugar-NDGA conjugates containing triazole-linkages possessed good solubility in water. NDGA-(triazol-galactose)₄ (12b) and NDGA-(triazol-glucose) ₄ (12c) were found to act as inhibitors against human hepatocellular carcinoma Hep3B cells in culture.

Original language	English
Pages (from-to)	380-382
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	21
Issue number	1
DOIs	https://doi.org/10.1016/j.bmcl.2010.10.137
Publication status	Published - 2011 Jan 1

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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abstract = "Three perglycosylated nordihydroguaiaretic acids (NDGA) were synthesized through the Huiseng 1,3-dipolar cycloaddition reaction. These sugar-NDGA conjugates containing triazole-linkages possessed good solubility in water. NDGA-(triazol-galactose)4 (12b) and NDGA-(triazol-glucose) 4 (12c) were found to act as inhibitors against human hepatocellular carcinoma Hep3B cells in culture.",

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AU - Huang, Ru Chih C.

AU - Lee, Yuan C.

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