G protein β3 subunit variant and essential hypertension in Taiwan - A case-control study

Cheng Ho Tsai, Hung I. Yeh, Yusan Chou, Hsin Fu Liu, Tzu Yao Yang, Jyh Chwan Wang, Nancy M. Wang, Jan Gowth Chang

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Abstract

Recent studies have shown that a C825T polymorphism of the gene encoding the G protein β3 subunit contributes to the genesis of essential hypertension. However, the link between the gene and blood pressure is not consistently found in different populations. The aim of the present study is to investigate this issue in Taiwan. We analyzed the allelic status in 302 hypertensive (age, 60±11 years; male/female, 136/166) and 199 normotensive subjects (62±15 years; male/female, 90/109). Our result showed that the T allelic was more frequently seen in the hypertensive group than the normotensive, but the difference did not reach statistic significance (56.5 vs. 54.3%, P>0.1). Subsequent analysis demonstrated a similar trend in the female (58.7 vs. 53.7%, P>0.1) but a reverse trend in the male (53.7 vs. 55%, P>0.1). Another finding was that the T allele frequency in all the groups was over 50%, markedly higher than those reported in whites. In conclusion, the observation suggests that the polymorphism in the G protein gene is not likely to play an important role in the manifestation of high blood pressure in Taiwan. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)191-195
Number of pages5
JournalInternational Journal of Cardiology
Volume73
Issue number2
DOIs
Publication statusPublished - 2000 Apr 28

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All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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