Abstract
Recent studies have shown that a C825T polymorphism of the gene encoding the G protein β3 subunit contributes to the genesis of essential hypertension. However, the link between the gene and blood pressure is not consistently found in different populations. The aim of the present study is to investigate this issue in Taiwan. We analyzed the allelic status in 302 hypertensive (age, 60±11 years; male/female, 136/166) and 199 normotensive subjects (62±15 years; male/female, 90/109). Our result showed that the T allelic was more frequently seen in the hypertensive group than the normotensive, but the difference did not reach statistic significance (56.5 vs. 54.3%, P>0.1). Subsequent analysis demonstrated a similar trend in the female (58.7 vs. 53.7%, P>0.1) but a reverse trend in the male (53.7 vs. 55%, P>0.1). Another finding was that the T allele frequency in all the groups was over 50%, markedly higher than those reported in whites. In conclusion, the observation suggests that the polymorphism in the G protein gene is not likely to play an important role in the manifestation of high blood pressure in Taiwan. Copyright (C) 2000 Elsevier Science Ireland Ltd.
| Original language | English |
|---|---|
| Pages (from-to) | 191-195 |
| Number of pages | 5 |
| Journal | International Journal of Cardiology |
| Volume | 73 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2000 Apr 28 |
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All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine
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G protein β3 subunit variant and essential hypertension in Taiwan - A case-control study. / Tsai, Cheng Ho; Yeh, Hung I.; Chou, Yusan; Liu, Hsin Fu; Yang, Tzu Yao; Wang, Jyh Chwan; Wang, Miau-Yaun; Chang, Jan Gowth.
In: International Journal of Cardiology, Vol. 73, No. 2, 28.04.2000, p. 191-195.Research output: Contribution to journal › Article
TY - JOUR
T1 - G protein β3 subunit variant and essential hypertension in Taiwan - A case-control study
AU - Tsai, Cheng Ho
AU - Yeh, Hung I.
AU - Chou, Yusan
AU - Liu, Hsin Fu
AU - Yang, Tzu Yao
AU - Wang, Jyh Chwan
AU - Wang, Miau-Yaun
AU - Chang, Jan Gowth
PY - 2000/4/28
Y1 - 2000/4/28
N2 - Recent studies have shown that a C825T polymorphism of the gene encoding the G protein β3 subunit contributes to the genesis of essential hypertension. However, the link between the gene and blood pressure is not consistently found in different populations. The aim of the present study is to investigate this issue in Taiwan. We analyzed the allelic status in 302 hypertensive (age, 60±11 years; male/female, 136/166) and 199 normotensive subjects (62±15 years; male/female, 90/109). Our result showed that the T allelic was more frequently seen in the hypertensive group than the normotensive, but the difference did not reach statistic significance (56.5 vs. 54.3%, P>0.1). Subsequent analysis demonstrated a similar trend in the female (58.7 vs. 53.7%, P>0.1) but a reverse trend in the male (53.7 vs. 55%, P>0.1). Another finding was that the T allele frequency in all the groups was over 50%, markedly higher than those reported in whites. In conclusion, the observation suggests that the polymorphism in the G protein gene is not likely to play an important role in the manifestation of high blood pressure in Taiwan. Copyright (C) 2000 Elsevier Science Ireland Ltd.
AB - Recent studies have shown that a C825T polymorphism of the gene encoding the G protein β3 subunit contributes to the genesis of essential hypertension. However, the link between the gene and blood pressure is not consistently found in different populations. The aim of the present study is to investigate this issue in Taiwan. We analyzed the allelic status in 302 hypertensive (age, 60±11 years; male/female, 136/166) and 199 normotensive subjects (62±15 years; male/female, 90/109). Our result showed that the T allelic was more frequently seen in the hypertensive group than the normotensive, but the difference did not reach statistic significance (56.5 vs. 54.3%, P>0.1). Subsequent analysis demonstrated a similar trend in the female (58.7 vs. 53.7%, P>0.1) but a reverse trend in the male (53.7 vs. 55%, P>0.1). Another finding was that the T allele frequency in all the groups was over 50%, markedly higher than those reported in whites. In conclusion, the observation suggests that the polymorphism in the G protein gene is not likely to play an important role in the manifestation of high blood pressure in Taiwan. Copyright (C) 2000 Elsevier Science Ireland Ltd.
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UR - http://www.scopus.com/inward/citedby.url?scp=0034724712&partnerID=8YFLogxK
U2 - 10.1016/S0167-5273(00)00209-6
DO - 10.1016/S0167-5273(00)00209-6
M3 - Article
C2 - 10817859
AN - SCOPUS:0034724712
VL - 73
SP - 191
EP - 195
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
IS - 2
ER -